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Full-Text Articles in Engineering
Fabrication Of Silicon Microneedles For Dermal Interstitial Fluid Extraction In Human Subjects, Caleb A. Berry
Fabrication Of Silicon Microneedles For Dermal Interstitial Fluid Extraction In Human Subjects, Caleb A. Berry
Electronic Theses and Dissertations
The goal of this project is to design and develop a fabrication process for silicon microneedle arrays to extract dermal interstitial fluid (ISF) from human skin. ISF is a cell- free, living tissue medium that is known to contain many of the same, clinical biomarkers of general health, stress response and immune status as in blood. However, a significant barrier to adoption of ISF as a diagnostic matrix is the lack of a rapid, minimally invasive method of access and collection for analysis. Microfabricated chips containing arrays of microneedles that can rapidly and painlessly access and collect dermal ISF for …
Development Of A Counter-Flow Thermal Gradient Microfluidic Device, Shayan Davani
Development Of A Counter-Flow Thermal Gradient Microfluidic Device, Shayan Davani
Doctoral Dissertations
This work presents a novel counter-flow design for thermal stabilization of microfluidic thermal reactors. In these reactors, precise control of temperature of the liquid sample is achieved by moving the liquid sample through the thermal zones established ideally through the conduction in the solid material of the device. The goal here is to establish a linear thermal distribution when there is no flow and to minimize the temperature change at flow condition. External convection as well as internal flowinduced effects influence the prescribed thermal distribution. The counter-flow thermal gradient device developed in this study is capable of both stabilizing the …
Micro Electrostatic Actuation Of A Silicon Diaphragm, Matthew W. Samples
Micro Electrostatic Actuation Of A Silicon Diaphragm, Matthew W. Samples
Master's Theses
There are a number of applications, from hearing aids to microfluidic pumps, which utilize micro-scale actuating diaphragms. These MEMS (micro-electromechanical system) devices can be actuated by electrostatic forces, which utilize an induced electric field to pull two charged plates towards one another. Such devices were fabricated and electrostatic actuation of the diaphragms was performed to analyze its viability as a micro-speaker. The long-term performance of such products requires adequate diaphragm deflection to create audible pressure waves with relatively low maximum stresses to ensure a high cycle fatigue life. With these requirements, initial calculations and FEA (finite element analysis) were performed …
Continuous Glucose Monitoring Microsensor With A Nanoscale Conducting Matrix And Redox Mediator, Daniel Pesantez
Continuous Glucose Monitoring Microsensor With A Nanoscale Conducting Matrix And Redox Mediator, Daniel Pesantez
Legacy Theses & Dissertations (2009 - 2024)
The major limiting factor in kidney clinical transplantation is the shortage of transplantable organs. The current inability to distinguish viability from non-viability on a prospective basis represents a major obstacle in any attempt to expand organ donor criteria. Consequently, a way to measure and monitor a relevant analyte to assess kidney viability is needed. For the first time, the initial development and characterization of a metabolic microsensor to assess kidney viability is presented. The rate of glucose consumption appears to serve as an indicator of kidney metabolism that may distinguish reversible from irreversible kidney damage. The proposed MetaSense (Metabolic Sensor) …
The Development Of An In Vivo Spinal Fusion Monitor Using Microelectromechanical (Mems) Technology To Create Implantable Microsensors, Lisa Anne Ferrara
The Development Of An In Vivo Spinal Fusion Monitor Using Microelectromechanical (Mems) Technology To Create Implantable Microsensors, Lisa Anne Ferrara
ETD Archive
Surgical fusion of the spine is a conventional approach, and often last alternative, to the correction of a degenerative painful spinal segment. The procedure involves the surgical removal of the intervertebral disc at the problematic site, and the placement of a bone graft that is commonly harvested from the patients iliac crest and placed within the discectomized space. The surrounding bone is expected to incorporate and remodel into the bone graft to eventually provide an immobilized site. Spinal instrumentation often accompanies the bone graft to provide further immobility to the targeted site, thus augmenting the fusion process. However, the status …
Mems (Micro-Electro-Mechanical-Systems) Based Microfluidic Platforms For Magnetic Cell Separation, Pulak Nath
Mems (Micro-Electro-Mechanical-Systems) Based Microfluidic Platforms For Magnetic Cell Separation, Pulak Nath
ETD Archive
Microfluidic platforms for magnetic cell separation were developed and investigated for isolation of magnetic particles and magnetically tagged cells from a fluidic sample. Two types of magnetic separation platforms were considered: an Isodynamic Open Gradient Magnetic Sorter (OGMS) and a multistage bio-ferrograph. Miniaturized magnets were designed using magnetostatic simulation software, microfluidic channels were fabricated using microfabrication technology and magnetic separation was investigated using video microscopy and digital image processing. The isodynamic OGMS consisted of an external magnetic circuit and a microfabricated channel (biochip) with embedded magnetic elements. The biochip is placed inside the magnetic field of the external circuit to …
Mems Transducer For Hearing Aid Device, Houwen Tang
Mems Transducer For Hearing Aid Device, Houwen Tang
Electronic Theses and Dissertations
A study of implantable middle ear MEMS piezoelectric transducer for hearing aids was developed. The physical vibration deflection at the tip of the transducer is simulated using finite element method. Further, a study of thermoelastic damping effect of four designed MEMS mirrors used as resonators is presented. An optical measurement system based on Mach-Zehnder interferometer is