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Theses/Dissertations

Biomedical Engineering and Bioengineering

Cleveland State University

Diffusion

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Full-Text Articles in Engineering

One-Dimensional Radial Diffusion Of Small Molecules (376 Da) In Bone Tissue, Kurt W. Farrell Jan 2011

One-Dimensional Radial Diffusion Of Small Molecules (376 Da) In Bone Tissue, Kurt W. Farrell

ETD Archive

The flow of nutrients through any biological tissue is important to maintain homeostasis. If the transport process is understood, medical research teams can better design medications, prosthetic implants, and tissue scaffolds. Additionally, transport rates help physicians to better understand disease states and wound healing, including minor injuries such as breaks and sprains, which will aid in better diagnoses. We developed a novel method that measures the rate of diffusion in vitro, of fluorescein sodium salt. Samples were incubated at 37°C in a 5 CO2 atmosphere for various periods of time. Samples were sliced and analyzed using Image-Pro Plus and ...


Investigations Of Anatomical Connectivity In The Internal Capsule Of Macaques With Diffusion Magnetic Resonance Imaging, Kyle Andrew Ignatius Taljan Jan 2011

Investigations Of Anatomical Connectivity In The Internal Capsule Of Macaques With Diffusion Magnetic Resonance Imaging, Kyle Andrew Ignatius Taljan

ETD Archive

Understanding anatomical connectivity is crucial for improving outcomes of deep brain stimulation surgery. Tractography is a promising method for noninvasively investigating anatomical connectivity, but connections between subcortical regions have not been closely examined by this method. As many connections to subcortical regions converge at the internal capsule (IC), we investigate the connectivity through the IC to three subcortical nuclei (caudate, lentiform nucleus, and thalamus) in 6 macaques. We show that a statistical correction for a known distance-related artifact in tractography results in large changes in connectivity patterns. Our results suggest that care should be taken in using tractography to assess ...