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Theses/Dissertations

Biomedical Engineering and Bioengineering

Cleveland State University

Chemical Engineering

Publication Year

Articles 1 - 5 of 5

Full-Text Articles in Engineering

Modeling Liver Diseases Using Hepatic Cell Microarrays, Alexander David Roth Jan 2018

Modeling Liver Diseases Using Hepatic Cell Microarrays, Alexander David Roth

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Hepatocellular carcinoma (HCC) is an invasive and aggressive cancer of the liver that arises due to chronic cirrhosis. Research into understanding HCC has focused on two-dimensional (2D) and three-dimensional (3D) technologies to simulate the liver microenvironment and use animal models to model how HCC affects the rest of the body. 3D hydrogel models are desired because they can mimic the transport behavior observed in vivo by structurally mimicking the extracellular matrix (ECM) without the ethical concerns of animal models. However, hydrogels can be toxic to cells and require optimal procedures for appropriate handling. In this study, we created 3D models ...


Solute Partitioning In Elastin-Like Polypeptides: A Foundation For Drug Delivery Applications, Eric Helm Jan 2015

Solute Partitioning In Elastin-Like Polypeptides: A Foundation For Drug Delivery Applications, Eric Helm

ETD Archive

No abstract provided.


Characterization Of Highly Concentrated Elastin-Like Polypeptide Solutions: Rheometric Properties And Phase Separation Analysis, Kevin Michael Otto Jan 2015

Characterization Of Highly Concentrated Elastin-Like Polypeptide Solutions: Rheometric Properties And Phase Separation Analysis, Kevin Michael Otto

ETD Archive

Elastin-like polypeptides (ELPs) are environmentally responsive biopolymers. These protein based polymers are specific in that they exhibit phase separation in response to a number of stimuli. Some of these stimuli include temperature, light, and pH. There are a large number of factors to consider when designing ELP constructs that allow for control of the transitioning behavior, some of which include amino acid sequences, protein concentration, salt concentration, and the polymer chain length. Elastin-like polypeptides are soluble in water at low temperatures, however, upon an increase in temperature, the proteins become insoluble in water and phase separate. This point of temperature ...


Lipid Production By Scenedesmus Dimorphus: Comparison Of Extraction Techniques And Effect Of Sodium Nitrate Concentration, Bahareh Kanani Jan 2013

Lipid Production By Scenedesmus Dimorphus: Comparison Of Extraction Techniques And Effect Of Sodium Nitrate Concentration, Bahareh Kanani

ETD Archive

No abstract provided.


Moving Horizon Estimation With Dynamic Programming, Mohan Kumar Ramalingam Jan 2013

Moving Horizon Estimation With Dynamic Programming, Mohan Kumar Ramalingam

ETD Archive

Moving Horizon Estimation(MHE) is a optimization based strategy to state estimation. It involves computation of arrival cost, a penalty term, based on the MHE cost function. Minimization of this arrival cost is done through various methods. All these methods use nonlinear programming optimization technique which gives the estimate. The main idea of MHE revolves around minimizing the estimation cost function. The cost function is dependent on prediction error computation from data and arrival cost summarization. The major issue that hampers the MHE is choosing the arrival cost for ensuring stability of the overall estimation and computational time. In order ...