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Determining The Transport Enhancement Of Sodium Fluorescein In Mechanically-Loaded Canine Tibia, Andrew Joseph Zak
Determining The Transport Enhancement Of Sodium Fluorescein In Mechanically-Loaded Canine Tibia, Andrew Joseph Zak
ETD Archive
Quantitative research concerning the impact of mechanical loading on the transport properties of bone has several critical applications. One such application is the effect of a microgravity environment, where the lack of mechanical forces on bone has been shown to negatively impact both growth and repair. A method has been developed in our lab that can potentially allow for the measurement of the effective permeability of large molecules (i.e., 300-15,000 Da in size) in bone tissue under both unloaded and mechanically loaded conditions. In proof-of-concept experiments, previous students have measured the effective diffusivity of the model solute, sodium fluorescein (376 …
Time And Temperature Dependent Surface Tension Measurements Of Responsive Protein-Based Polymer Surfactant Solutions, Hakan Celik
Time And Temperature Dependent Surface Tension Measurements Of Responsive Protein-Based Polymer Surfactant Solutions, Hakan Celik
ETD Archive
A three-armed star elastin-like polypeptide (ELP-foldon) has thermoreversible character which exhibits phase separation above a transition temperature (Tt) in physiologic salt concentrations. At lower salt concentration, the ELP-foldon behaves like a thermoresponsive surfactant, exhibiting micelle formation above its Tt. The purpose of this study is characterize the surfactant behavior of the ELP-foldon at air-liquid interface by measuring the surface tension. The surface tension is measured as a function of time for different ELP concentrations from 10 nM to 50 ℗æM and over range of temperatures from 25 to 35 ℗¿ using the axisymmetric drop shape analysis (ADSA). The ADSA is …