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Biomedical Devices and Instrumentation

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Full-Text Articles in Engineering

Characterization Of Oxone Mediated Tempo-Oxidized Nano Cellulose Mixed-Matrix Membranes During Ultrafiltration And Hemodialysis, Kristyn Robling May 2020

Characterization Of Oxone Mediated Tempo-Oxidized Nano Cellulose Mixed-Matrix Membranes During Ultrafiltration And Hemodialysis, Kristyn Robling

Biomedical Engineering Undergraduate Honors Theses

The ninth leading cause of death in the United States is kidney disease, and hemodialysis is the process most commonly prescribed for treatment. It utilizes a selectively permeable membrane filter to remove toxins such as urea from the blood and retain necessary protein levels. However, traditional filters, such as cellulose triacetate, used during dialysis can be inefficient in terms of separation performance and reduction of fouling. Recent exploration of nanoparticles has resulted in the creation of Oxone Mediated TEMPO-Oxidized Nano Cellulose which has properties that are believed to increase hydrophilicity, increase tensile capacity, decrease membrane resistance and lower fouling, making ...


A Wearable Mechatronic Device For Hand Tremor Monitoring And Suppression: Development And Evaluation, Yue Zhou Dec 2019

A Wearable Mechatronic Device For Hand Tremor Monitoring And Suppression: Development And Evaluation, Yue Zhou

Electronic Thesis and Dissertation Repository

Tremor, one of the most disabling symptoms of Parkinson's disease (PD), significantly affects the quality of life of the individuals who suffer from it. These people live with difficulties with fine motor tasks, such as eating and writing, and suffer from social embarrassment. Traditional medicines are often ineffective, and surgery is highly invasive and risky. The emergence of wearable technology facilitates an externally worn mechatronic tremor suppression device as a potential alternative approach for tremor management. However, no device has been developed for the suppression of finger tremor that has been validated on a human.

It has been reported ...


Blood Glucose Predictor, Jessica Patterson Dec 2019

Blood Glucose Predictor, Jessica Patterson

Electrical Engineering

For my senior project, I perform data analysis using statistical methods to determine body metrics that correlate with blood glucose levels. Working with Dr. Tina Smilkstein, I take repeat measurements from 6 different volunteers to establish trends in bodily metric data. The data taken includes weight, body fat, pulse rate, VO2, blood glucose, blood pressure, hours slept, and quality of sleep. Using these values, I use the program MiniTab to view results.

A few examples of correlations with blood glucose found in this project are:

  • Systolic blood pressure for females had a regression line of 124.0 -0.3366*Blood ...


Characterization Of Nano-Cellulose Based Composites For Biomedical Applications, Mitchell P. Chesley Aug 2019

Characterization Of Nano-Cellulose Based Composites For Biomedical Applications, Mitchell P. Chesley

Electronic Theses and Dissertations

The number of orthopedic surgeries performed globally has steadily increased over the past decade due to the standardization of procedures as well as technological advancements. During this time orthopedic devices have been composed predominantly of metals, such as Titanium, Vanadium, Molybdenum, and Stainless steel, as well as their alloys, due to the high strength and durability of these materials. However, metals may, in fact, be suboptimal for orthopedic devices. For example, metals exhibit Young’s modulus much greater than the surrounding bone, inducing localized stress-shielding promoting cortical atrophy, which can lead to osteoporosis. In recent years polymers have been successfully ...


Development Of A Statistical Shape-Function Model Of The Implanted Knee For Real-Time Prediction Of Joint Mechanics, Kalin Gibbons Aug 2019

Development Of A Statistical Shape-Function Model Of The Implanted Knee For Real-Time Prediction Of Joint Mechanics, Kalin Gibbons

Boise State University Theses and Dissertations

Outcomes of total knee arthroplasty (TKA) are dependent on surgical technique, patient variability, and implant design. Non-optimal design or alignment choices may result in undesirable contact mechanics and joint kinematics, including poor joint alignment, instability, and reduced range of motion. Implant design and surgical alignment are modifiable factors with potential to improve patient outcomes, and there is a need for robust implant designs that can accommodate patient variability. Our objective was to develop a statistical shape-function model (SFM) of a posterior stabilized implant knee to instantaneously predict output mechanics in an efficient manner. Finite element methods were combined with Latin ...


Impedance-Based Microfluidic Platform For Quantitative Biology, Amin Mansoorifar Jul 2019

Impedance-Based Microfluidic Platform For Quantitative Biology, Amin Mansoorifar

Mechanical Engineering Research Theses and Dissertations

Dielectric properties of biological cells are functions of cellular structure, content, state, and phenotype. Dielectric spectroscopy (DS) is a nondestructive method to characterize dielectric properties by measuring impedance data over a frequency range. This method has been widely used for various applications such as counting, sizing, and monitoring biological cells and particles. Recently, this method has been suggested to be utilized in various stages of the drug discovery process due to its low sample consumption and fast analysis time.

In this thesis, we have developed a lab-on-a-chip device that uses an electro-activated microwells array for capturing, making DS measurements on ...


Remote Navigation And Contact-Force Control Of Radiofrequency Ablation Catheters, Daniel Gelman Jun 2019

Remote Navigation And Contact-Force Control Of Radiofrequency Ablation Catheters, Daniel Gelman

Electronic Thesis and Dissertation Repository

Atrial fibrillation (AF), the most common and clinically significant heart rhythm disorder, is characterized by rapid and irregular electrical activity in the upper chambers resulting in abnormal contractions. Radiofrequency (RF) cardiac catheter ablation is a minimally invasive curative treatment that aims to electrically correct signal pathways inside the atria to restore normal sinus rhythm. Successful catheter ablation requires the complete and permanent elimination of arrhythmogenic signals by delivering transmural RF ablation lesions contiguously near and around key cardiac structures. These procedures are complex and technically challenging and, even when performed by the most skilled physician, nearly half of patients undergo ...


The Theia Soteria: Alternative Design For Safer Initial Entry During Laparoscopic Procedures, Kayla Dubois, Patrick Ryan, Madelyn Joanis Jun 2019

The Theia Soteria: Alternative Design For Safer Initial Entry During Laparoscopic Procedures, Kayla Dubois, Patrick Ryan, Madelyn Joanis

Honors Theses

Laparoscopic procedures account for 15 million surgeries worldwide [1], with the initial entry into the peritoneal cavity accounting for 33-50% of all major laparoscopic complications [7]. This initial entry is the most dangerous as surgeons must enter the cavity using a sharp object with no visibility and space between the outer surface of the cavity and internal tissues. During the initial entry into the peritoneal cavity, the patients undergoing laparoscopic procedures are at a high risk for damage to internal organs and vasculature, necessitating the development of a device to protect these internal tissues and increase patient safety.


Cej Ankle Support Report, Christine Prothe, James Baldwin, Erik Espinoza Jun 2019

Cej Ankle Support Report, Christine Prothe, James Baldwin, Erik Espinoza

Biomedical Engineering

This document provides information about an ankle support device designed to allow for ankle dorsiflexion and plantar flexion. In this document the product’s specifications, objectives and expectations are outlined. Included in this document is background information, stage gate process, prototype design development and considerations, and qualification requirements.


Sand Foot: A Prosthesis For Walking On Sand, Samantha A. Galicinao, John Dewing, Daniel Dugan Dotson, Christopher Urasaki Jun 2019

Sand Foot: A Prosthesis For Walking On Sand, Samantha A. Galicinao, John Dewing, Daniel Dugan Dotson, Christopher Urasaki

Biomedical Engineering

This critical design report describes the product development of a prosthesis for use on sand. Quality of Life Plus (QL+), a national non-profit organization aimed to develop prostheses for veterans and people with disabilities, introduced this project and its accompanying challenger, Sgt. Brady, to Cal Poly’s Interdisciplinary Senior Project class in September 2018. After consulting with Sgt. Brady and QL+ and performing extensive research, the Sand Foot team defined customer requirements and engineering specifications to meet these requirements. Comfortability, durability, and sandproof were key customer requirements. Several conceptual models were brainstormed and a final design was selected based on ...


Cooking Hand Multi-Tool, Amanda D. Meares, Amy H. Wilson, Ethan G. Littlejohn, Duania A. Evans Jun 2019

Cooking Hand Multi-Tool, Amanda D. Meares, Amy H. Wilson, Ethan G. Littlejohn, Duania A. Evans

Biomedical Engineering

The purpose of this project was to devise a solution for Jorge Segura, a US Marine who was wounded in Afghanistan and had to have his non-dominant arm amputated above the elbow. His current prosthetic attachments are not suited to cooking tasks, so he needed a way to cook more effectively with either prosthetic attachments or accessibility devices. The main tasks that he needed help with was holding down food on cutting boards and stabilizing pots, pans, and bowls especially when stirring. After background research, exploring commercially available devices, and talking with our challenger, our solution was to design three ...


House Calls Mobile Virtual Stethoscope, Abigail Lindquist, Abigael Donohue, Trey Nahhas Jun 2019

House Calls Mobile Virtual Stethoscope, Abigail Lindquist, Abigael Donohue, Trey Nahhas

Biomedical Engineering

The purpose of this scope of work is to outline the progress of the Virtual Stethoscope design and development project as sponsored by House Calls Mobile. This device looks to provide accessible at-home care for patients all over the country through the mobile phone stethoscope attachment. With the virtual stethoscope technology, patients will be able to perform high-quality, in-home observation of heart, stomach, and lung sounds to be transmitted to a physician in real time. Eliminating the need to travel to a doctor’s office encourages patients to perform more regular checkups, increasing their likelihood potentially of life-saving early diagnoses ...


A 3-Dimensional In Silico Test Bed For Radiofrequency Ablation Catheter Design Evaluation And Optimization, Carolyn Teng Jun 2019

A 3-Dimensional In Silico Test Bed For Radiofrequency Ablation Catheter Design Evaluation And Optimization, Carolyn Teng

Master's Theses and Project Reports

Atrial fibrillation (AF) is the disordered activation of the atrial myocardium, which is a major cause of stroke. Currently, the most effective, minimally traumatic treatment for AF is percutaneous catheter ablation to isolate arrhythmogenic areas from the rest of the atrium. The standard in vitro evaluation of ablation catheters through lesion studies is a resource intensive effort due to tissue variability and visual measurement methods, necessitating large sample sizes and multiple prototype builds. A computational test bed for ablation catheter evaluation was built in SolidWorks® using the morphology and dimensions of the left atrium adjacent structures. From this geometry, the ...


Applying An Innovative Idea To Kidney Stone Removal, Jack Beaty Jun 2019

Applying An Innovative Idea To Kidney Stone Removal, Jack Beaty

Honors Theses

Renal lithiasis, commonly referred to as “kidney stones” is a condition in which the urine composition crystallizes and cannot pass through the ureter, causing pain and discomfort. Renal lithiasis can be caused by diet, infection, reduced water retention, or hereditary disorders; each of which results in a distinct stone composition [1]. Stone compositions can vary between calcium oxalate, struvite, uric acid, and cystine[2]. Each stone type, however, provides the same pain to the patient and the same potential risk of blocking the urinary system.

Kidney stone symptoms may include but are not limited to: pain in the lower back ...


Evaluation Of Individual Finger Forces During Activities Of Daily Living In Healthy Individuals And Those With Hand Arthritis, Michael Riddle May 2019

Evaluation Of Individual Finger Forces During Activities Of Daily Living In Healthy Individuals And Those With Hand Arthritis, Michael Riddle

Electronic Thesis and Dissertation Repository

Hand-Osteoarthritis (H-OA) leads to pain, loss of grip strength, and decreased hand function. Current treatment for H-OA involves joint protection programs (JPP) which seek to reduce joint loading during activity. The use of wearable technology to measure hand forces during activity has the potential to determine the effectiveness of JPP. The objective of this thesis was to develop and validate a method of directly measuring finger forces during the performance of activities of daily living, and then use that system to measure the envelope of hand forces during activity in healthy individuals and in patients with H-OA. A commercially-available capacitive ...


Final Design Report For The Bioburden Pre-Cleaning Device And Dr. Mark Rasnake At The University Of Tennessee Medical Center, Katherine Elizabeth Stiles, Megan Pitz, Kayla Franklin, Simran Dayal, Austin Bullock May 2019

Final Design Report For The Bioburden Pre-Cleaning Device And Dr. Mark Rasnake At The University Of Tennessee Medical Center, Katherine Elizabeth Stiles, Megan Pitz, Kayla Franklin, Simran Dayal, Austin Bullock

Chancellor’s Honors Program Projects

No abstract provided.


Diffuse Reflectance Spectroscopy To Quantify In Vivo Tissue Optical Properties: Applications In Human Epithelium And Subcutaneous Murine Colon Cancer, Gage Joseph Greening May 2019

Diffuse Reflectance Spectroscopy To Quantify In Vivo Tissue Optical Properties: Applications In Human Epithelium And Subcutaneous Murine Colon Cancer, Gage Joseph Greening

Theses and Dissertations

Colorectal cancer is the 4th most common and 2nd deadliest cancer. Problems exist with predicting which patients will respond best to certain therapy regimens. Diffuse reflectance spectroscopy has been suggested as a candidate to optically monitor a patient’s early response to therapy and has been received favorably in experimentally managing other cancers such as breast and skin. In this dissertation, two diffuse reflectance spectroscopy probes were designed: one with a combined high-resolution microendoscopy modality, and one that was optimized for acquiring data from subcutaneous murine tumors. For both probes, percent errors for estimating tissue optical properties (reduced scattering coefficient ...


A Bioinstrumentation Active Learning Educational Module: The Design Of A Working Temperature Sensor Using A Ntc Thermistor, Baylor Bush May 2019

A Bioinstrumentation Active Learning Educational Module: The Design Of A Working Temperature Sensor Using A Ntc Thermistor, Baylor Bush

Biomedical Engineering Undergraduate Honors Theses

The Department of Biomedical Engineering at the University of Arkansas has continued to develop over the years, with more students enrolling in the program each year. Within the first biomedical engineering course, Introduction to Biomedical Engineering, various topics are introduced to students, and the topic of bioinstrumentation has been one of the most complex and difficult topics for students to comprehend through just a few lectures. In order to aid students in grasping these intricate concepts, an active learning module was developed in which students can work in groups to build a simple thermistor circuit as a temperature sensor. The ...


Using Peripheral Venous Pressure Waveforms To Predict Key Hemodynamic Parameters, Ali Zohair A Alalawi May 2019

Using Peripheral Venous Pressure Waveforms To Predict Key Hemodynamic Parameters, Ali Zohair A Alalawi

Theses and Dissertations

Analysis of peripheral venous pressure (PVP) waveforms is a novel method of monitoring intravascular volume. Two cohorts were used to study the hemodynamics change of the body state and its influence on the PVP using (1) dehydration setting with infants suffering from pyloric stenosis and (2) hemorrhage setting during a craniosynostosis elective surgery. The goal of this research is to develop a minimally invasive method of analyzing the PVP waveforms and find correlations with volume loss.

Twenty-three pyloric stenosis patients PVP were acquired at five stages and were divided into euvolemic, normal fluid volume, and hypovolemic, significant fluid loss. Seven ...


The Effects Of Bone Morphogenic Protein 2 On The Viability And Proliferation Of Dental Pulp Stem Cell Isolates, Joseph Cinelli May 2019

The Effects Of Bone Morphogenic Protein 2 On The Viability And Proliferation Of Dental Pulp Stem Cell Isolates, Joseph Cinelli

UNLV Theses, Dissertations, Professional Papers, and Capstones

Growth factor is an umbrella term used to describe a signaling molecule present in organisms that serves the purpose of influencing a stimulatory or inhibitory response from the target cell it acts on. Growth factors are categorized and classified by the types of tissues they act on and the cellular responses they illicit. For example, there are growth factors that act primarily in connective tissue on fibroblasts and they are aptly classified as the fibroblast growth factor family. Similarly, there is another family of growth factors that act on bone forming cells, among others, and they are known as bone ...


The Affective Perceptual Model: Enhancing Communication Quality For Persons With Pimd, Jadin Tredup May 2019

The Affective Perceptual Model: Enhancing Communication Quality For Persons With Pimd, Jadin Tredup

UNLV Theses, Dissertations, Professional Papers, and Capstones

Methods for prolonged compassionate care for persons with Profound Intellectual and Multiple Disabilities (PIMD) require a rotating cast of import people in the subjects life in order to facilitate interaction with the external environment. As subjects continue to age, dependency on these people increases with complexity of communications while the quality of communication decreases. It is theorized that a machine learning (ML) system could replicate the attuning process and replace these people to promote independence. This thesis extends this idea to develop a conceptual and formal model and system prototype.

The main contributions of this thesis are: (1) proposal of ...


Development Of A Force-Based Ream Vector Measurement System For Glenoid Reaming Simulation, David Axford Apr 2019

Development Of A Force-Based Ream Vector Measurement System For Glenoid Reaming Simulation, David Axford

Electronic Thesis and Dissertation Repository

Glenoid reaming is a technically challenging step during total shoulder arthroplasty surgery that may be improved through frequent practice and exposure to simulation training. At our institution, a vibration haptic glenoid reaming simulator is being developed that simulates the vibrations felt during glenoid reaming. This thesis presents the development of a force-based reamer vector measurement system that allows the simulator to measure the user’s net applied force and reamer angle of approach. This capability allows for the simulation of eccentric reaming maneuvers commonly used to adjust the glenoid orientation. The system error was characterized and evaluated using a robot ...


Tissue Equivalent Gellan Gum Gel Materials For Clinical Mri And Radiation Dosimetry, Pawel Brzozowski Apr 2019

Tissue Equivalent Gellan Gum Gel Materials For Clinical Mri And Radiation Dosimetry, Pawel Brzozowski

Electronic Thesis and Dissertation Repository

Hydrogels contain high amount of water allowing their use as surrogates to human tissues with specific properties that can be tuned by additives. Gellan gum is a gel-forming material of interest and is a replacement for other common gelling agent with limited use as a tissue phantom. Therefore, this thesis examines the application of gellan gum gels as a novel magnetic resonance imaging (MRI) phantom with a design of experiments model to obtain tunable properties. The analysis was extended to include mechanical and electrical properties with a separate design of experiment. Gels doped with synthesized superparamagnetic iron oxide nanoparticles (SPIONs ...


Cuffed Pediatric Endotracheal Tubes, Jennifer Nutter, Emmanuela Oppong, Colleen Pouliot Mar 2019

Cuffed Pediatric Endotracheal Tubes, Jennifer Nutter, Emmanuela Oppong, Colleen Pouliot

Honors Theses

Endotracheal tubes (ET) are used to provide patients with an adequate airway when they are unable to breathe on their own. ET tubes can be used in emergency situations, surgical procedures, and on-floor intubations. The two main types of ET tubes are cuffed and uncuffed. Due to the fragile structure of a child's throat, uncuffed tubes are primarily used in pediatric patients. Uncuffed tubes can slip out of place resulting in air leakage and improper oxygenation. In contrast, cuffed ET tubes provide a proper seal to the airway and prevent against aspiration. The following work proposes an improved design ...


Heat Stress Identification, Nathanial Nyberg, Christina Santini, Zachary Miller Mar 2019

Heat Stress Identification, Nathanial Nyberg, Christina Santini, Zachary Miller

Biomedical Engineering

This document contains all information pertinent to the creation of the desired product and how the desired product fulfills the problem statement. This document clearly defines the customer requirements and how they relate to engineering specifications, metrics that will define the boundaries that the desired product must lie within. This document will then reveal all concepts that were considered during the design phase of this project and how those concepts were compared. This includes all quantitative parameters that provided a clear front-runner concept and the rationale for those parameters and the values and weight assigned to them.

Then this document ...


Pressure Cylinder Controlled Release Valve, Alexa Dominique Balbuena Mar 2019

Pressure Cylinder Controlled Release Valve, Alexa Dominique Balbuena

Biomedical Engineering

This project aims to integrate an automatic gas release system in a pre-existing scaffold fabrication process for tissue engineering applications.

To form the proper scaffold structure, the fabrication process is heavily influenced by the change in its surrounding pressure. The current production involves a pressure transducer and electric valve that is managed manually to create a suitable pressure environment for the scaffold. This method, although functional, proves to be ineffective when creating several batches; the user needs to constantly monitor the developing pressure profile and alter voltage parameters accordingly to create a linear gas release under a predetermined slope.

To ...


Esophageal Mapping And Temperature Regulation For Catheter Ablation, Madison J. Keith, Morgan A. Jawitz, Sarah L. Sanders Mar 2019

Esophageal Mapping And Temperature Regulation For Catheter Ablation, Madison J. Keith, Morgan A. Jawitz, Sarah L. Sanders

Biomedical Engineering

The purpose of this document is to provide a development summary for a proposed esophageal temperature mapping device used during catheter ablation. Catheter ablation therapy is performed in the left atria with hot or cold materials to create scar tissue to treat atrial fibrillation. However, utilized temperatures and absorbed energies from the catheter can cause undesired esophageal damage. Therefore, this medical device is designed to monitor esophageal temperature and map its location during catheter ablation. If dangerous temperatures are reached, the device will alarm the surgeon.

This document provides an in-depth overview of the esophageal temperaturemapping device’s development and ...


Automated Microscope Stage, Corin Nishimoto, Alison Flesch, Theo Anastos Mar 2019

Automated Microscope Stage, Corin Nishimoto, Alison Flesch, Theo Anastos

Biomedical Engineering

This document seeks to describe the background information, customer requirements, design specifications, indications for use, selected materials, proposed budget, prototypes, final design, manufacturing processes, and testing methods regarding the CellOptimizer automated microscope stage product.


Fluid Delivery System For A Cell Culture On A Microfluidic Chip, Austin J. Roeder, Colleen A. Richards, Emily A. Matteson Mar 2019

Fluid Delivery System For A Cell Culture On A Microfluidic Chip, Austin J. Roeder, Colleen A. Richards, Emily A. Matteson

Biomedical Engineering

This project report provides a description of the progress made in the development of a fluid delivery system for a microfluidic cell culture on a chip. The system is intended to be used in a humidified incubator in a university laboratory and the fluid delivery system is required to exist and operate within that incubator for extended periods of time. Therefore, the system will be gravity-driven and contain no electronic components. The key specification of the system is to provide fluid flow at a constant velocity.

After manufacturing and testing the device, all specifications were met except for the fluid ...


Slit Lamp Ophthalmoscope Redesign, Michael Hostetler, Austin Mattmiller, Alexis Brewer Mar 2019

Slit Lamp Ophthalmoscope Redesign, Michael Hostetler, Austin Mattmiller, Alexis Brewer

Biomedical Engineering

The slit lamp ophthalmoscope is used by ophthalmologists for diagnosis of pathologies in the eye. The device is used for identifying ocular diseases or indications of other possible systemic diseases to treat them before the diseases progress. Redesign of the ergonomics and adjustment mechanisms of the slit lamp ophthalmoscope will attempt to improve the compatibility of the device across a greater variety of patients. The wider headrest tower of 12.75 inches, the wider table cutout of 12 inches, and the 12 inches of extension of the headrest tower creates a better ergonomic fit for the patient and doctor. The ...