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Full-Text Articles in Engineering
A Machine Learning Approach For Predicting Clinical Trial Patient Enrollment In Drug Development Portfolio Demand Planning, Ahmed Shoieb
A Machine Learning Approach For Predicting Clinical Trial Patient Enrollment In Drug Development Portfolio Demand Planning, Ahmed Shoieb
Masters Theses
One of the biggest challenges the clinical research industry currently faces is the accurate forecasting of patient enrollment (namely if and when a clinical trial will achieve full enrollment), as the stochastic behavior of enrollment can significantly contribute to delays in the development of new drugs, increases in duration and costs of clinical trials, and the over- or under- estimation of clinical supply. This study proposes a Machine Learning model using a Fully Convolutional Network (FCN) that is trained on a dataset of 100,000 patient enrollment data points including patient age, patient gender, patient disease, investigational product, study phase, blinded …
A New Reinforcement Learning Algorithm With Fixed Exploration For Semi-Markov Decision Processes, Angelo Michael Encapera
A New Reinforcement Learning Algorithm With Fixed Exploration For Semi-Markov Decision Processes, Angelo Michael Encapera
Masters Theses
"Artificial intelligence or machine learning techniques are currently being widely applied for solving problems within the field of data analytics. This work presents and demonstrates the use of a new machine learning algorithm for solving semi-Markov decision processes (SMDPs). SMDPs are encountered in the domain of Reinforcement Learning to solve control problems in discrete-event systems. The new algorithm developed here is called iSMART, an acronym for imaging Semi-Markov Average Reward Technique. The algorithm uses a constant exploration rate, unlike its precursor R-SMART, which required exploration decay. The major difference between R-SMART and iSMART is that the latter uses, in addition …