Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Engineering
Metabolic Modeling And Engineering Of Gas Fermentation In Bubble Column Reactors, Jin Chen
Metabolic Modeling And Engineering Of Gas Fermentation In Bubble Column Reactors, Jin Chen
Doctoral Dissertations
Gas fermentation is an attractive route to produce alternative fuels and chemicals from non-food feedstocks, such as waste gas streams from steel mills and synthesis gas (mainly CO and H2) produced from municipal solid waste through gasification. While commercial development of gas fermentation technology is underway, many research problems must be addressed to further advance the technology towards economic competitiveness. A particularly important challenge is to develop integrated metabolic and transport models that describe gas fermentation in industrially relevant bubble column reactors. I have developed and evaluated a spatiotemporal metabolic model for bubble column reactors with the syngas …
Industrial Robustness: Understanding The Mechanism Of Tolerance For The Populus Hydrolysate Tolerant Strain Of Clostridium Thermocellum, Jessica Leigh Linville
Industrial Robustness: Understanding The Mechanism Of Tolerance For The Populus Hydrolysate Tolerant Strain Of Clostridium Thermocellum, Jessica Leigh Linville
Doctoral Dissertations
An industrially robust microorganism that can efficiently degrade and convert lignocellulosic biomass into ethanol and next-generation fuels is required to economically produce future sustainable liquid transportation fuels. The anaerobic, thermophilic, cellulolytic bacterium Clostridium thermocellum is a candidate microorganism for such conversions but it, like many bacteria, is sensitive to potential toxic inhibitors developed in the hydrolysate produced during biomass processing. Microbial processes leading to tolerance of the inhibitory compounds found in the pretreated biomass hydrolysate are likely complex and involve multiple genes. In this study, a 17.5% v/v Populus hydrolysate tolerant mutant strain of C. thermocellum was developed by directed …