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Differential Effects Of Ovariectomy On The Mechanical Properties Of Cortical And Cancellous Bone In Rat Femora And Vertebrae, Debbie Chachra, J.M. Lee, M. Kasra, Marc Grynpas
Differential Effects Of Ovariectomy On The Mechanical Properties Of Cortical And Cancellous Bone In Rat Femora And Vertebrae, Debbie Chachra, J.M. Lee, M. Kasra, Marc Grynpas
Debbie Chachra
The purpose of this study was to evaluate the effects of ovariectomy on the mechanical properties of bone in the aged Sprague-Dawley rat model of osteoporosis. Eight female rats were sacrificed at the start of the study, at the age of four months. Twenty-four remaining rats were then bilaterally ovariectomized (OVX), and another twenty-four served as controls. Eight rats from each group were sacrificed at five, ten or fifteen weeks. The mean density of L1 vertebral bodies from OVX rats was lower than in their control counterparts, as was the compressive modulus, the ultimate compressive stress and the toughness. The …