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Full-Text Articles in Engineering

The Analysis And Deployment Of A Fully Open Monitoring System In The Sri Lankan Deduroya Basin: The 4onse Project, Massimiliano Cannata, Daniele Strigaro, Imran Shahid, Rangajeewa Ratnayake, B.H. Sudantha Jul 2018

The Analysis And Deployment Of A Fully Open Monitoring System In The Sri Lankan Deduroya Basin: The 4onse Project, Massimiliano Cannata, Daniele Strigaro, Imran Shahid, Rangajeewa Ratnayake, B.H. Sudantha

Free and Open Source Software for Geospatial (FOSS4G) Conference Proceedings

The 4onse project studies non-conventional monitoring systems fully based on open technologies (hardware, standard protocols, software and data) for the management of resources and natural hazards in developing countries. After the design of hydro-meteorological stations and software for the collection, management and distribution of data, the study involves the installation of 30 stations in the Deduroya Oya river basin in Sri Lanka. The system will be analysed to fully understand the real cost of ownership, data quality and applicability in real situations. If properly validated, these systems can provide an alternative solution, effective and sustainable for the protection of property ...


Ndvi And Lst Extraction Of Modis Data Under A Gis Open Source Application - Rickettsia Study Case In Angola, Ana Cláudia Teodoro, Lia Duarte, Patrícia Barradas, T. L. Mateus, Zoraima Neto Jul 2018

Ndvi And Lst Extraction Of Modis Data Under A Gis Open Source Application - Rickettsia Study Case In Angola, Ana Cláudia Teodoro, Lia Duarte, Patrícia Barradas, T. L. Mateus, Zoraima Neto

Free and Open Source Software for Geospatial (FOSS4G) Conference Proceedings

Fevers of unknown origin can have different aetiologies. The overlapping symptomatology of rickettsial infection and other endemic diseases that cause fever leads to a misdiagnosis or under-diagnosis of spotted fever group of Rickettsia (SFGR).

To better understand the epidemiology of this vector-borne disease in Angola, a comprehensive seroprevalence study was conducted investigating the exposure to SFGR in a sample of 92 febrile, Malaria and Yellow Fever negative human plasma specimen, collected to the study of the national surveillance of febrile syndromes between 2016 and 2017, in Angola.

The seroprevalence of IgG antibodies against SFG Rickettsia in humans was calculated by ...


Crowdsourcing The Georeferencing Of Historical Pictures, Timothée Produit, Nicolas Blanc, Sarah Composto, Jens Ingensand, Loic Furhoff Jul 2018

Crowdsourcing The Georeferencing Of Historical Pictures, Timothée Produit, Nicolas Blanc, Sarah Composto, Jens Ingensand, Loic Furhoff

Free and Open Source Software for Geospatial (FOSS4G) Conference Proceedings

Countless organizations own archive pictures which are not used due to the difficulty of localizing them. Only the participation of volunteers can help to identify the image content. Through an accessible web interface called smapshot, citizens are able to georeference historical images without any prior specific competence. To avoid the volunteers to face the complexity of 3D digitization and navigation, we implemented a state of the art photogrammetry camera orientation algorithm in the platform. Currently several thousand images from all around Switzerland have been georeferenced by the crowd. At this time the tool is mainly used by the population for ...


Istsos Version 3, Cannata Massimiliano, Milan Antonovic, Daniele Strigaro, Mirko Cardoso Jul 2018

Istsos Version 3, Cannata Massimiliano, Milan Antonovic, Daniele Strigaro, Mirko Cardoso

Free and Open Source Software for Geospatial (FOSS4G) Conference Proceedings

istSOS version 3 is a new full stack open source application framework that, implementing the Sensor Observation Service standard from the OGC and including some special features, offers the capability to manage and disseminate observation from sensors networks. istSOS3 has been redesigned with the mission to solve the problems of high loads environments and quality of service. After some recent researches that have shown that istSOS version 2 is not adequate to meet high demanding environment in terms of high concurrency, big data and performance, istSOS version 3 has been rewritten from ground up taking advantages from the latest technologies ...


Robust Railroad Cable Detection In Rural Areas From Mls Point Clouds, Máté Cserép, Péter Hudoba, Zoltán Vincellér Jul 2018

Robust Railroad Cable Detection In Rural Areas From Mls Point Clouds, Máté Cserép, Péter Hudoba, Zoltán Vincellér

Free and Open Source Software for Geospatial (FOSS4G) Conference Proceedings

Monitoring of the railroad infrastructure is crucial for safety concerns and accident prevention. This task requires regular surveillance which is nowadays still carried out by expensive and time consuming manual visual inspections in many countries. The problem of railroad cable recognition (contact cables, catenary cables, return current cables) in rural areas based on LiDAR point clouds has it own methods, but current state of the art solutions suffer from extremely high computational load due the extensive size of the datasets. In this study we analyzed and compared novel robust solutions focusing on minimizing the assumptions (positions and distances of track ...


Seasonal Impacts Of Climate Change On Future Peak River Discharge In The U.S. Northeast, Christina Wu May 2018

Seasonal Impacts Of Climate Change On Future Peak River Discharge In The U.S. Northeast, Christina Wu

Environmental & Water Resources Engineering Masters Projects

This research uses projected changes in future precipitation to calculate the changes in the magnitude, frequency, and timing of streamflow, particularly peak annual flows, in the U.S. Northeast through 20 representative watersheds. Temperature and precipitation data on a 3-hourly time step from five climate projection from the North American Regional Climate Change Assessment Program (NARCCAP) are downscaled and bias- corrected using the Spatial Downscaling and Bias Correction (SDBC) method. These data are used to force a regional hydrological model (WRF-Hydro) to estimate daily future streamflow. The changes in magnitude at various return intervals of peak flow events are determined ...


Formation Of Low-Molecular-Weight Dissolved Organic Nitrogen In Two-Stage And Four-Stage Pre-Denitrification Biological Nutrient Removal Processes, Siwei Chen May 2018

Formation Of Low-Molecular-Weight Dissolved Organic Nitrogen In Two-Stage And Four-Stage Pre-Denitrification Biological Nutrient Removal Processes, Siwei Chen

Environmental & Water Resources Engineering Masters Projects

To alleviate the eutrophication caused by excessive loading of nutrients, the upgrading of conventional activated sludge (CAS) process to biological nutrients removal (BNR) process has been widely applied in USA. In this study, we found that the dissolved inorganic nitrogen (DIN) release can be effectively controlled by this upgrading, but dissolved organic nitrogen (DON) especially LMW-DON, which now is regarded as another important N source for supporting growth of phytoplankton in coastal water, cannot be removed effectively by BNR systems, especially by four-stage BNR systems. Different pre-denitrification BNR processes have different LMW-DON production rates. A four-stage pre-denitrification BNR releases more ...


Development Of Application Software For Water System Data Management, Visualization, And Analysis With The Shiny Framework, Nicholas Zinck May 2018

Development Of Application Software For Water System Data Management, Visualization, And Analysis With The Shiny Framework, Nicholas Zinck

Environmental & Water Resources Engineering Masters Projects

A comprehensive watershed protection plan includes the collection of water quality, meteorological, and hydrological data. Large amounts of data can be difficult to manage if proper systems are not put in place for data management. Poor data management can be detrimental and may result in data loss, poor quality data, or underutilized data due to the lack of an efficient process of querying, visualizing, and analyzing data. Database software is a great solution to store and organize large datasets, yet database software often lack data visualization and analysis tools. Commonly, databases are paired with an outside application specialized for data ...


Application Of Ce-Qual-W2: Wachusett Reservoir Contaminant Spill Modeling, William Yan May 2018

Application Of Ce-Qual-W2: Wachusett Reservoir Contaminant Spill Modeling, William Yan

Environmental & Water Resources Engineering Masters Projects

This research was done to investigate the fate and transport of a simulated contaminant spill into Wachusett Reservoir using the CE-QUAL-W2 model. The reservoir is located in central Massachusetts (north east of Worcester) and was first filled in 1908. The Massachusetts Water Resource Authority (MWRA) uses the reservoir as a primary source of drinking water for the metropolitan Boston area. The 65-billion-gallon reservoir is replenished by 9 tributaries and also supplemented by the transfer of water from Quabbin Reservoir (412 billion-gallon capacity) through the Quabbin Aqueduct. This transfer is used to meet system water demands, manage the water surface elevation ...


Factors Impacting The Cultivation, Structure, And Oxygen Profiles Of Oxygenic Photogranules For Aeration-Free Wastewater Treatment, Megan Hann Apr 2018

Factors Impacting The Cultivation, Structure, And Oxygen Profiles Of Oxygenic Photogranules For Aeration-Free Wastewater Treatment, Megan Hann

Environmental & Water Resources Engineering Masters Projects

Oxygenic photogranules (OPGs) are novel biogranules which have successfully treated wastewater without external aeration at the bench scale. The formation of OPGs under both static and hydrodynamic conditions is a unique phenomenon which has no known counterpart. This report examines some of the granulation mechanisms and structural and functional differences between statically and hydrodynamically cultivated OPGs. As previously reported, filamentous cyanobacteria are an essential component of both types of OPGs. The addition of Oscillatoria in augmented activated sludge inoculum showed successful static OPG formation in a shorter time (28 vs 35 days) and produced more settled OPGs than native sludge ...


Determination Of The Rate Constant For Reaction Of Ozone With 1-Hexene In Water, Pranav Mashankar Apr 2018

Determination Of The Rate Constant For Reaction Of Ozone With 1-Hexene In Water, Pranav Mashankar

Environmental & Water Resources Engineering Masters Projects

Low molecular weight aldehydes such as formaldehyde may be formed as disinfection byproducts (DBPs) of ozonation when low molecular weight, aliphatic, alpha olefins are present as contaminants in water. Such alkenes form a small but significant part of crude oil, and would therefore be present in water contaminated with an oil spill. This project studied the kinetics of the reaction between ozone and 1-hexene in water as part of a study to predict the effects of an oil spill on the water quality in the Wachusett reservoir in Massachusetts. The data for the reaction rate constant for the aqueous ozonolysis ...


The Construction Of Open Data Portal Using Dkan For Integrate To Multiple Japanese Local Government Open Data, Toshikazu Seto, Yoshihide Sekimoto Jan 2018

The Construction Of Open Data Portal Using Dkan For Integrate To Multiple Japanese Local Government Open Data, Toshikazu Seto, Yoshihide Sekimoto

Free and Open Source Software for Geospatial (FOSS4G) Conference Proceedings

In recent years, the Code for Japan, a civic tech community in Japan, has focused on the context of the FOSS4G. Consequently, the Japanese have published open data in more than 150 local governments, but these data are almost simply provided as a file on their website. And also CKAN portal are used less than 20 cities. In this study, we built open data platform that uses DKAN for integrated open data distribution of Japanese local governments.


Polymeric Peptide Mimics For Protein Delivery, Coralie Backlund Jan 2018

Polymeric Peptide Mimics For Protein Delivery, Coralie Backlund

Doctoral Dissertations

The plasma membrane is a major obstacle in the development and use of biomacromolecules for intracellular applications. Consequently, proteins with intracellular targets represent an enormous, yet under studied avenue for therapeutics. Extended research has aimed at facilitating intracellular delivery of exogenous proteins using protein transduction domains (PTDs), which allow transport of bioactive molecules into cells. Synthetic polymers, inspired by PTDs, provide a well-controlled platform to vary molecular architecture for structure activity relationship studies. Specifically, this thesis focuses on the use of ring-opening metathesis, a facile and efficient polymerization technique, through which we can vary structural parameters to optimize delivery of ...


Flood Risk Assessment, Management And Perceptions In A Changing World, Katherine Schlef Jan 2018

Flood Risk Assessment, Management And Perceptions In A Changing World, Katherine Schlef

Doctoral Dissertations

Floods are a global challenge that is increasing due to changes in climate and human populations. Using an interdisciplinary approach, this work contributes novel methodologies and knowledge to three key challenges associated with floods. The first chapter builds upon the atmospheric and statistical sciences to provide a general methodology for climate informed approaches to projecting long-term flood events based on large-scale ocean-atmospheric processes. The second chapter builds upon the engineering, decision analysis, and economics disciplines to integrate climate-informed projections with decision-scaling, a decision-making under uncertainty framework, to further flood risk management. The third chapter builds upon the social sciences to ...


Origins And Seasonal Variation Of Disinfection Byproduct Precursors, Ran Zhao Jan 2018

Origins And Seasonal Variation Of Disinfection Byproduct Precursors, Ran Zhao

Doctoral Dissertations

Disinfection byproducts (DBPs) are formed from the disinfectant (e.g., chlorine) reacting with components of natural organic matter (NOM) in water drawn from surface water supplies, and are considered as the cause of potential serious human health problems. DBP precursors originate in large reservoirs from at least three types of sources: (1) watershed or allochthonous, (2) algal or autochthonous, and (3) bottom sediments or benthic. The properties of the NOM and the DBP precursor content of that NOM are unique to each source.

The first objective of this dissertation was to use temporal and spatial water quality data from a ...


Brain Science = Biology + Engineering, Jennifer Welborn, Guangyu Xu, Morton Sternheim, Chris Emery Jan 2018

Brain Science = Biology + Engineering, Jennifer Welborn, Guangyu Xu, Morton Sternheim, Chris Emery

Science and Engineering Saturday Seminars

This interdisciplinary (physical and life sciences) seminar exposes participants to cutting edge research at UMASS, Amherst, on cell imaging using a chip which gathers a variety of data on the activities of single cells. Part of the seminar will be a presentation of current research in this area, followed by hands-on activities and a visit to the lab where this research is conducted. Application of this new technology to brain research will be discussed as well as the NGSS standards alignment and classroom applications at various levels and disciplines.


Effect Of Substrate Roughness, Slope, And Body Size On Climbing Behavior And Performance Of Juvenile American Eels (Anguilla Rostrata), Zahra Anwar Jan 2018

Effect Of Substrate Roughness, Slope, And Body Size On Climbing Behavior And Performance Of Juvenile American Eels (Anguilla Rostrata), Zahra Anwar

Environmental & Water Resources Engineering Masters Projects

The effect of ramp slope and substrate grain size on the passage of juvenile American Eel (Anguilla rostrata) over indoor ramps was tested from May – August 2016. Two size classes of fish (300 glass eels 50 – 70 mm and 300 elvers 90-114 mm), five substrates varying in coarseness (Substrate 1: 0.18-0.25 mm grain size, Substrate 2: 0.25-0.60 mm grain size,

Substrate 3; 0.60-1.00 mm grain size, Substrate 4: 1.00 – 2.00 mm grain size, Substrate 5: 2.00-

4.00 mm grain size), and three ramp slopes (25, 35 and 45 degrees) were ...


A Safety And Emissions Analysis Of Continuous Flow Intersections, Joshua Wolfgram Jan 2018

A Safety And Emissions Analysis Of Continuous Flow Intersections, Joshua Wolfgram

Transportation Engineering Masters Projects

Increasing travel demand, and challenges associated with high percentages of left-turning vehicles, have encouraged the introduction of significant infrastructure advancements. Certain alternative intersection designs, such as continuous flow intersections, median U-turns, and jughandles, eliminate the traditional protected left-turn, increasing the intersection's optional efficiency. While the design and operations of these intersection types have been studied to varying degrees, their safety and emissions-related impacts are not well-understood.

This project develops a series of microsimulation models for two continuous flow intersections (CFI) located in Missouri and Colorado, and uses the Surrogate Safety Assessment Model (SSAM) to determine the impact of those ...


Intersection Signal Control And Design For Improved Person Mobility And Air Quality In Urban Multimodal Transportation Systems, Farnoush Khalighi Jan 2018

Intersection Signal Control And Design For Improved Person Mobility And Air Quality In Urban Multimodal Transportation Systems, Farnoush Khalighi

Doctoral Dissertations

Alternative geometric designs (e.g. roundabouts) and multi-objective signal control strategies are promising measures to improve sustainability of traffic networks. However, roundabouts are mostly used because of their safety and operational advantages. There has been less attention to the environmental performance of roundabouts. Also, the existing studies have been mostly used through field measurements and current simulation models, which need high calibration efforts and they are not inclusive in terms of considering all influencing factors on vehicular emissions at roundabouts. Furthermore, the existing real-time signal control strategies do not account for the emission rates of different vehicle types (e.g ...


An Experimental Investigation Of The Influence Of Sampling On The Behavior Of Intermediate Soils, William Lukas Jan 2018

An Experimental Investigation Of The Influence Of Sampling On The Behavior Of Intermediate Soils, William Lukas

Doctoral Dissertations

Laboratory tests were performed in order to determine the effects of tube sampling disturbance on intermediate soils. Synthetic soils composed of Kaolin clay and silica silt, a reconstituted natural silt, and block sample specimens of a sensitive marine clay were tested. Tube sampling disturbance was simulated in a triaxial stress path system with bender element using the Ideal Sampling Approach prior to reconsolidation and undrained shear. ISA strain cycles of ±0.5, ±1 and ±3% were used to represent progressively greater degrees of disturbance. The influence of overconsolidation ratio (OCR) was explored by testing at OCRs of 1, 1.8 ...


Design For Sustainability Through A Life Cycle Assessment Conceptual Framework Integrated Within Product Lifecycle Management, Renpeng Zou Jan 2018

Design For Sustainability Through A Life Cycle Assessment Conceptual Framework Integrated Within Product Lifecycle Management, Renpeng Zou

Masters Theses

The need to include sustainable design principles during product realization poses several challenges in need of research. The demand for greener products has increased while competition has shortened product realization processes. Product Lifecycle Management (PLM) provides solutions in accelerating the development process and time to market by managing the information through a full life cycle of a product line. Life Cycle Assessment (LCA) provides a way to predict the environmental impacts that should be expected over the complete life cycle of a given product, but LCA methods are not well suited to efficient comparison of product alternatives during early design ...


High Strain Rate Dynamic Response Of Aluminum 6061 Micro Particles At Elevated Temperatures And Varying Oxide Thicknesses Of Substrate Surface, Carmine Taglienti Jan 2018

High Strain Rate Dynamic Response Of Aluminum 6061 Micro Particles At Elevated Temperatures And Varying Oxide Thicknesses Of Substrate Surface, Carmine Taglienti

Masters Theses

Cold spray is a unique additive manufacturing process, where a large number of ductile metal micro particles are deposited to create new surface coatings or free-standing structures. Metallic particles are accelerated through a gas stream, reaching velocities of over 1 km/s. Accelerated particles experience a high-strain-rate microscopic ballistic collisions against a target substrate. Large amounts of kinetic energy results in extreme plastic deformation of the particles and substrate. Though the cold spray process has been in use for decades, the extreme material science behind the deformation of particles has not been well understood due to experimental difficulties arising from ...


All-Red Clearance Intervals For Use In The Left-Turn Application Of Flashing Yellow Arrows, Francis Tainter Jan 2018

All-Red Clearance Intervals For Use In The Left-Turn Application Of Flashing Yellow Arrows, Francis Tainter

Masters Theses

With the advancement of implementation for a novel traffic control device, the Flashing Yellow Arrow (FYA), agencies across the country have continually sought strategies to improve intersection operations and safety, specifically with respect to the left-turn application. More so, permissive left-turn intervals have been communicated to drivers using several traffic signal indications; however, most frequently these phases are represented through the circular green (CG) ball and more recently, the FYA. Previous research in this area determined that the FYA indication produced the most effective communication of permissive left-turns. Further, this previous research led to the inclusion of the FYA in ...


The Application Of Usability Engineering Methods To Evaluate And Improve A Clinical Decision Support System, Kristine Desotto Jan 2018

The Application Of Usability Engineering Methods To Evaluate And Improve A Clinical Decision Support System, Kristine Desotto

Masters Theses

Delays in the process of diagnosing and treating cancer are common and lead to confusion and undesirable outcomes. Care coordinators are often embedded within the system of care to manage follow-up care. Electronic and real-time reminder systems can be used to support the care coordinator’s work, but electronic health record (EHR) usability is known to be poor. This study, completed in collaboration with the Department of Veterans Affairs (VA) Connecticut Healthcare System, evaluated the Cancer Coordination and Tracking System (CCTS), an EHR-linked, web-based tool for cancer care management.

A set of expert-driven and user-driven usability engineering methods was applied ...


A Graphene-Based Microfluidic Platform For Electrocrystallization And In Situ X-Ray Diffraction, Shuo Sui, Yuxi Wang, Christos Dimitrakopoulos, Sarah L. Perry Jan 2018

A Graphene-Based Microfluidic Platform For Electrocrystallization And In Situ X-Ray Diffraction, Shuo Sui, Yuxi Wang, Christos Dimitrakopoulos, Sarah L. Perry

Chemical Engineering Faculty Publication Series

Here, we describe a novel microfluidic platform for use in electrocrystallization experiments. The device incorporates ultra-thin graphene-based films as electrodes and as X-ray transparent windows to enable in situ X-ray diffraction analysis. Furthermore, large-area graphene films serve as a gas barrier, creating a stable sample environment over time. We characterize different methods for fabricating graphene electrodes, and validate the electrical capabilities of our device through the use of methyl viologen, a redox-sensitive dye. Proof-of-concept electrocrystallization experiments using an internal electric field at constant potential were performed using hen egg-white lysozyme (HEWL) as a model system. We observed faster nucleation and ...


Control Of Thiol-Maleimide Reaction Kinetics In Peg Hydrogel Networks, Lauren E. Jansen, Lenny J. Negrón-Piñeiro, Sualyneth Galarza, Shelly Peyton Jan 2018

Control Of Thiol-Maleimide Reaction Kinetics In Peg Hydrogel Networks, Lauren E. Jansen, Lenny J. Negrón-Piñeiro, Sualyneth Galarza, Shelly Peyton

Chemical Engineering Faculty Publication Series

Michael-type addition reactions are widely used to polymerize biocompatible hydrogels. The thiol-maleimide modality achieves the highest macromer coupling efficiency of the reported Michael-type pairs, but the resulting hydrogel networks are heterogeneous, because polymerization is faster than the individual components can be manually mixed. The reactivity of the thiol dictates the overall reaction speed, which can be slowed in organic solvents and acidic buffers. Since these modifications also reduce the biocompatibility of resulting hydrogels, we investigated a series of biocompatible buff­ers and crosslinkers to decelerate gelation while maintaining high cell viability. We found that lowering the polymer weight percentage (wt ...


Anomalously Diffusing And Persistently Migrating Cells In 2d And 3d Culture Environments, Igor D. Luzhansky, Alyssa D. Schwartz, Joshua D. Cohen, John P. Macmunn, Lauren E. Barney, Lauren Jansen, Shelly Peyton Jan 2018

Anomalously Diffusing And Persistently Migrating Cells In 2d And 3d Culture Environments, Igor D. Luzhansky, Alyssa D. Schwartz, Joshua D. Cohen, John P. Macmunn, Lauren E. Barney, Lauren Jansen, Shelly Peyton

Chemical Engineering Faculty Publication Series

Appropriately chosen descriptive models of cell migration in biomaterials will allow researchers to characterize and ultimately predict the movement of cells in engineered systems for a variety of applications in tissue engineering. The persistent random walk (PRW) model accurately describes cell migration on two-dimensional (2D) substrates. However, this model inherently cannot describe subdiffusive cell movement, i.e. migration paths in which the root mean square displacement increases more slowly than the square root of the time interval. Subdiffusivity is a common characteristic of cells moving in confined environments, such as three-dimensional (3D) porous scaffolds, hydrogel networks, and in vivo tissues ...


Syllabus: Drinking Water, Sanitation, And Global Development, Emily Kumpel Jan 2018

Syllabus: Drinking Water, Sanitation, And Global Development, Emily Kumpel

Sustainability Education Resources

Within the past three decades, more than 2.6 billion people have gained access to an improved water source and 2.1 billion have gained access to an improved sanitation facility. However, improved does not always mean people have safe, reliable, accessible, or equitable water and sanitation services. Waterborne diseases continue to cause and estimated 500,000 deaths each year. What causes waterborne diseases, and what is the role of engineered systems in their spread or prevention? How can we evaluate interventions to improve health and well-being? How can research address these challenges?


Does The Elicitation Mode Matter? Comparing Different Methods For Eliciting Expert Judgement, Claire Cruickshank Jan 2018

Does The Elicitation Mode Matter? Comparing Different Methods For Eliciting Expert Judgement, Claire Cruickshank

Masters Theses

An expert elicitation is a method of eliciting subjective probability distributions over key parameters from experts. Traditionally an expert elicitation has taken the form of a face-to-face interview; however, interest in using online methods has been growing. This thesis compares two elicitation modes and examines the effectiveness of an interactive online survey compared to a face-to-face interview. Differences in central values, overconfidence, accuracy and satisficing were considered. The results of our analysis indicated that, in instances where the online and face-to-face elicitations were directly comparable, the differences between the modes was not significant. Consequently, a carefully designed online elicitation may ...


Zwitterionic Peg-Pc Hydrogels Modulate The Foreign Body Response In A Modulus-Dependent Manner, Lauren Jansen, Luke D. Amer, Esther Y-T Chen, Thuy V. Nguyen, Leila S. Saleh, Todd Emrick, Wendy F. Liu, Stephanie J. Bryant, Shelly Peyton Jan 2018

Zwitterionic Peg-Pc Hydrogels Modulate The Foreign Body Response In A Modulus-Dependent Manner, Lauren Jansen, Luke D. Amer, Esther Y-T Chen, Thuy V. Nguyen, Leila S. Saleh, Todd Emrick, Wendy F. Liu, Stephanie J. Bryant, Shelly Peyton

Chemical Engineering Faculty Publication Series

Reducing the foreign body response (FBR) to implanted biomaterials will enhance their performance in tissue engineering. Poly(ethylene glycol) (PEG) hydrogels are increasingly popular for this application due to their low cost, ease of use, and the ability to tune their compliance via molecular weight and crosslinking densities. PEG hydrogels can elicit chronic inflammation in vivo, but recent evidence has suggested that extremely hydrophilic, zwitterionic materials and particles can evade the immune system. To combine the advantages of PEG-based hydrogels with the hydrophilicity of zwitterions, we synthesized hydrogels with co-monomers PEG and the zwitterion phosphorylcholine (PC). Recent evidence suggests that ...