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Full-Text Articles in Engineering

Ice-Binding Protein From Shewanella Frigidimarinas Inhibits Ice Crystal Growth In Highly Alkaline Solutions, Elizabeth Delesky, Shane D. Frazier, Jaqueline D. Wallat, Kendra L. Bannister, Chelsea Marie Heveran, Wil V. Srubar Iii Feb 2019

Ice-Binding Protein From Shewanella Frigidimarinas Inhibits Ice Crystal Growth In Highly Alkaline Solutions, Elizabeth Delesky, Shane D. Frazier, Jaqueline D. Wallat, Kendra L. Bannister, Chelsea Marie Heveran, Wil V. Srubar Iii

University Libraries Open Access Fund Supported Publications

The ability of a natural ice-binding protein from Shewanella frigidimarina (SfIBP) to inhibit ice crystal growth in highly alkaline solutions with increasing pH and ionic strength was investigated in this work. The purity of isolated SfIBP was first confirmed via sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and size-exclusion chromatography with an ultraviolet detector (SEC-UV). Protein stability was evaluated in the alkaline solutions using circular dichroism spectroscopy, SEC-UV, and SDS-PAGE. SfIBP ice recrystallization inhibition (IRI) activity, a measure of ice crystal growth inhibition, was assessed using a modified splat assay. Statistical analysis of results substantiated that, despite partial denaturation and ...


A Thermo-Poromechanics Finite Element Model For Predicting Arterial Tissue Fusion, Douglas P. Fankell Aug 2018

A Thermo-Poromechanics Finite Element Model For Predicting Arterial Tissue Fusion, Douglas P. Fankell

Mechanical Engineering Graduate Theses & Dissertations

This work provides modeling efforts and supplemental experimental work performed towards the ultimate goal of modeling heat transfer, mass transfer, and deformation occurring in biological tissue, in particular during arterial fusion and cutting. Developing accurate models of these processes accomplishes two goals. First, accurate models would enable engineers to design devices to be safer and less expensive. Second, the mechanisms behind tissue fusion and cutting are widely unknown; models with the ability to accurately predict physical phenomena occurring in the tissue will allow for insight into the underlying mechanisms of the processes. This work presents three aims and the efforts ...


Assessing A Low-Cost Methane Sensor Quantification System For Use In Complex Rural And Urban Environments, Ashley Monika Collier-Oxandale, Joanna Gordon Casey, Ricardo Antonio Piedrahita, John Ortega, Hannah Halliday, Jill Johnston, Michael Hannigan Jun 2018

Assessing A Low-Cost Methane Sensor Quantification System For Use In Complex Rural And Urban Environments, Ashley Monika Collier-Oxandale, Joanna Gordon Casey, Ricardo Antonio Piedrahita, John Ortega, Hannah Halliday, Jill Johnston, Michael Hannigan

University Libraries Open Access Fund Supported Publications

Low-cost sensors have the potential to facilitate the exploration of air quality issues on new temporal and spatial scales. Here we evaluate a low-cost sensor quantification system for methane through its use in two different deployments. The first was a 1-month deployment along the Colorado Front Range and included sites near active oil and gas operations in the Denver-Julesburg basin. The second deployment was in an urban Los Angeles neighborhood, subject to complex mixtures of air pollution sources including oil operations. Given its role as a potent greenhouse gas, new low-cost methods for detecting and monitoring methane may aid in ...


Environmental And Reinforcement Effects On Concrete Expansion Undergoing Accelerated Alkali-Silica Reaction, David Graff Jun 2018

Environmental And Reinforcement Effects On Concrete Expansion Undergoing Accelerated Alkali-Silica Reaction, David Graff

Civil Engineering Graduate Theses & Dissertations

This thesis is a part of ongoing research investigating the effects of alkali-silica reactions (ASR) on concrete’s mechanical properties. Over 50 concrete specimens have been cast and cured to encourage ASR development to the point of damage in less than a year. Specimens include 42”×30”×10” shear specimens, 14”×14”×14” blocks, 6”×6”×14” prisms, 4”×4”×16” prisms, cylinders, and wedge splitting test specimens. Some samples are stored in a fog room with conditions of 100oF, and 95% relative humidity and wrapped in burlap wetted or submerged in 1.0M sodium hydroxide (NaOH). Other specimens are ...


Archaeology And Conservation Of The Middle Phrygian Gate Complex At Gordion, Turkey, Semih Gönen, Richard F. Liebhart, Naomi F. Miller, Elspeth Dusinberre May 2018

Archaeology And Conservation Of The Middle Phrygian Gate Complex At Gordion, Turkey, Semih Gönen, Richard F. Liebhart, Naomi F. Miller, Elspeth Dusinberre

Classics Faculty Contributions

In 2016, a project was undertaken at Gordion, Turkey, to stabilize and conserve the remains of a rubble platform built early in the Middle Phrygian period (ca. 800–700 b.c.e.) under the vast Gate Complex leading to the megarons on the Citadel Mound. In the process, aspects of Middle Phrygian building strategies came to light that enhanced our understanding gained from the original excavation in the 1950s. This article outlines the archaeology of the Middle Phrygian Gate Complex and the sophisticated internal structures that lent stability to the rubble platform upon which it was built, and examines the ...


Seasonal Variability Of Airborne Particulate Matter And Bacterial Concentrations In Colorado Homes, Nicholas Clements, Patricia Keady, Joanne B. Emerson, Noah Fierer, Shelly L. Miller Apr 2018

Seasonal Variability Of Airborne Particulate Matter And Bacterial Concentrations In Colorado Homes, Nicholas Clements, Patricia Keady, Joanne B. Emerson, Noah Fierer, Shelly L. Miller

University Libraries Open Access Fund Supported Publications

Aerosol measurements were collected at fifteen homes over the course of one year in Colorado (USA) to understand the temporal variability of indoor air particulate matter and bacterial concentrations and their relationship with home characteristics, inhabitant activities, and outdoor air particulate matter (PM). Indoor and outdoor PM2.5 concentrations averaged ( st. dev.) 8.1 +/- 8.1 ug/m3 and 6.8 +/- 4.5 ug/m3, respectively. Indoor PM2.5 was statistically significantly higher during summer compared to spring and winter; outdoor PM2.5 was significantly higher for summer compared to spring and fall. The PM2.5 I/O ratio was ...


Effect Of Parameter Variations On The Electromagnetic Response Of A Metafilm Comprised Of Resonant Elements, Kendra L. Kumley Apr 2018

Effect Of Parameter Variations On The Electromagnetic Response Of A Metafilm Comprised Of Resonant Elements, Kendra L. Kumley

Electrical, Computer & Energy Engineering Graduate Theses & Dissertations

A metafilm is a 2-dimensional version of a metamaterial which consists of a single layer of resonators. The elements resonate with changes in frequency and are arranged periodically in an array. In this thesis, a theory describing the characteristics of arrays of resonant scatterers is thoroughly developed using analytical techniques (which have the advantages of providing physical insight and being computationally inexpensive) and demonstrated by numerical analysis. The analysis is based on a dipole interaction model, and is validated using independent full-wave numerical simulations. The technique derived in this work, the interaction polarizability approximation, takes into account variations in the ...


High Power Density High Efficiency Electrolytic-Free Single-Phase Led Drivers, Saad Pervaiz Apr 2018

High Power Density High Efficiency Electrolytic-Free Single-Phase Led Drivers, Saad Pervaiz

Electrical, Computer & Energy Engineering Graduate Theses & Dissertations

Owing to their high efficiencies and longer lifetimes, LEDs are increasingly replacing conventional light sources in various applications. Many of these applications require high-power-density and long-life LED drivers to fully benefit from the longer-life advantage provided by the LEDs. This thesis presents high-power-density, high-efficiency and longer-life LED drivers suitable for such applications. The proposed LED drivers eliminate the use of shorter-life electrolytic capacitors used for twice-line-frequency energy buffering with film/ceramic capacitor based stacked switched capacitor (SSC) energy buffers. The utilization of the SSC energy buffer significantly reduces the passive volume of the twice-line-frequency energy buffer compared to the use ...


Infrared Spectroscopy Of Buffer-Gas Cooled Molecules And Dynamics Of Bose Gases In Spherical Symmetry, Cameron Joseph Edgar Straatsma Apr 2018

Infrared Spectroscopy Of Buffer-Gas Cooled Molecules And Dynamics Of Bose Gases In Spherical Symmetry, Cameron Joseph Edgar Straatsma

Electrical, Computer & Energy Engineering Graduate Theses & Dissertations

Infrared absorption spectroscopy is a highly sensitive technique for probing molecular structure, and when combined with cold molecular beam methods it provides unparalleled spectral resolution and absorption sensitivity to transitions in isolated gas-phase molecules. The first part of this dissertation investigates molecular beams of large polyatomic molecules produced via laser ablation of solid targets inside a buffer-gas cooling cell. Using matrix isolation spectroscopy to study the ablation products of graphite, we observe carbon clusters C3 to C12 produced at a rate of approximately 1011-1012 molecules for every pulse of the ablation laser. In a similar ...


Metrology And Fabrication Of Volume-Structured Optical And Mechanical Features In Photopolymers, David John Glugla Apr 2018

Metrology And Fabrication Of Volume-Structured Optical And Mechanical Features In Photopolymers, David John Glugla

Electrical, Computer & Energy Engineering Graduate Theses & Dissertations

The ability to exert three-dimensional control over the intrinsic mechanical and optical properties of a solid are desirable in the fields of diffractive optical elements, shape programmable materials, and regenerative medicine. Although volume photostructuring in two-stage polymers has demonstrated the ability to produce such features, quantitative metrology of the photostructured elements remains a significant obstacle towards the widespread adoption of this patterning technique. Current methods to characterize photostructured features provide only qualitative information or fail to capture the entire material response. This inadequate characterization impedes the broader adoption of photostructuring to fabricate complex mechanical and optical devices.

In this thesis ...


Enabling User Space Secure Hardware, Michael Sean Coughlin Apr 2018

Enabling User Space Secure Hardware, Michael Sean Coughlin

Electrical, Computer & Energy Engineering Graduate Theses & Dissertations

User space software allows developers to customize applications beyond the limits of the privileged operating system. In this dissertation, we extend this concept to the hardware in the system, providing applications with the ability to define secure hardware; effectively enabling hardware to be treated as a user space resource. This addresses a significant challenge facing industry today, which has an increasing need for secure hardware. With the ever increasing leaks of private data, increasing use of a variety of computing platforms controlled by third parties, and increasing sophistication of attacks, secure hardware, now more than ever, is needed to provide ...


Simulating Optical Processes In Next-Generation Photovoltaics, Devin Michael Rourke Apr 2018

Simulating Optical Processes In Next-Generation Photovoltaics, Devin Michael Rourke

Electrical, Computer & Energy Engineering Graduate Theses & Dissertations

An increased need for cheap renewable energy has led to active research in solar technologies with improved efficiency and decreased production cost. Next-generation photovoltaic technologies, which utilize novel materials, processing techniques, and architectures, can improve light absorption and photocurrent generation. Experimental device development suffers from slow troubleshooting timescales, making device simulation a powerful tool for exploration of an ever-increasing parameter space. In this report, we develop and apply a finite element combined optical and electrical device model, which predicts the optoelectronic performance of photovoltaic devices. The model is applied to two systems: the near-infrared absorption enhancement of bulk heterojunction organic ...


Finite-Volumes Based Fdtd Material Dispersion Modeling, Neeti Prakash Sonth Apr 2018

Finite-Volumes Based Fdtd Material Dispersion Modeling, Neeti Prakash Sonth

Electrical, Computer & Energy Engineering Graduate Theses & Dissertations

The conventional FDTD, based on second-order central difference formula, is useful only so long as the electrical size of the structure is small. Phase error accumulates in the field calculations as the dimensions of the numerical FDTD lattice become larger. The Finite Volumes-Based 3-D second-order in time, fourth-order in space (FV24) modeling is highly capable of controlling such phase errors. Therefore, it is suitable for electrically large problems at coarse grid resolutions.

This work models the frequency dependence of material losses using an Auxiliary Differential Equation (ADE), a technique extensively discussed in the literature. (Elsherbeni and Demir, 2016.) To account ...


Plasmonic And Upconversion Nanoparticles For Bladder Cancer Treatment, Suehyun Katherine Cho Apr 2018

Plasmonic And Upconversion Nanoparticles For Bladder Cancer Treatment, Suehyun Katherine Cho

Electrical, Computer & Energy Engineering Graduate Theses & Dissertations

This thesis reports syntheses and surface modifications of various nanoparticles, including plasmonic, upconversion, and indium tin oxide nanoparticles for in situ bladder cancer detection and treatment.

The first part of this thesis reports a new and efficient polyethylene glycol (PEG) coating of gold nanorods (AuNRs). This coating technique is proven not only to be more stable in water compared to conventional coating methods, but also allows conjugation of an anti-epidermal growth factor receptor, C-225 antibodies. The AuNRs conjugated with C-225 antibodies (CNR) is then used in both in vitro and in vivo settings to demonstrate specific, targeted treatment capabilities by ...


High-Performance Power Converters For Telecom And Datacenter Applications, Ashish Kumar Apr 2018

High-Performance Power Converters For Telecom And Datacenter Applications, Ashish Kumar

Electrical, Computer & Energy Engineering Graduate Theses & Dissertations

Telecommunication systems and datacenters require compact isolated power converters that maintain high efficiencies across wide operating ranges. This thesis introduces high-efficiency high-power-density isolated dc-dc converters suitable for such applications. These converters are based on the impedance control network (ICN) resonant converter architecture, which enables high performance by achieving soft-switching across wide variations in operating conditions. First, an ICN-based telecom bus converter is developed. The design of this ICN converter is optimized using an enhanced augmented state-space analysis approach. A 1-MHz 550-W prototype of this ICN converter achieves a peak efficiency of 97.6%, maintains >95.3% full-power efficiency across 2 ...


Scalable Quantum Light Sources In Silicon Photonic Circuits, Cale Michael Gentry Apr 2018

Scalable Quantum Light Sources In Silicon Photonic Circuits, Cale Michael Gentry

Electrical, Computer & Energy Engineering Graduate Theses & Dissertations

Chip-scale integrated photonic circuits provide an attractive platform for the implementation of many quantum photonic technologies ranging from precise metrology to secure communication and quantum computation. In particular, silicon photonic platforms support micron-scale nonlinear optical sources of non-classical light which can be mass manufactured using the robust fabrication processes pioneered by the CMOS microelectronics industry. Integration of these quantum photonic sources with high-performance classical photonic devices on the same chip is required for truly scalable quantum information technologies. Integrated nonlinear resonators are investigated as sources of quantum mechanically correlated photon pair sources. An all-order dispersion engineering method is presented as ...


Context-Aware Anomaly Detection And Analysis Using Spatial-Temporal Data, Qi Liu Apr 2018

Context-Aware Anomaly Detection And Analysis Using Spatial-Temporal Data, Qi Liu

Electrical, Computer & Energy Engineering Graduate Theses & Dissertations

With the thriving of sensing and internet-of-things technologies, an increasing number of research communities and industries are stepping into the Era of Big Data. Following this technology trend, the amount and complexity of data generated by each domain are growing exponentially. The demand for automated monitoring, detecting and analyzing unusual events from those data are also increasing. These predictive analyses seek to identify and capture meaningful patterns in massive, highly heterogeneous data from various domains such as environmental sensing and cyber-physical systems. However, performing analysis such as anomaly detection faces a variety of challenges. For instance, the lack of prior ...


Wideband Monostatic Co-Channel Simultaneous Transmit And Receive (C-Star) Antenna And Array Systems, Ehab Abdalla Etellisi Apr 2018

Wideband Monostatic Co-Channel Simultaneous Transmit And Receive (C-Star) Antenna And Array Systems, Ehab Abdalla Etellisi

Electrical, Computer & Energy Engineering Graduate Theses & Dissertations

Most modern wireless communication systems operate either at different times or frequencies to avoid self-interferences. With these duplexing techniques, more resources are required due to the increased demand for higher data rate. Therefore, alternative solutions not involving more use of the time or frequency spectrum are needed. One of the possible solutions that has been recently gaining increased interest is often referred to as co-channel simultaneous transmit and receive (C-STAR). C-STAR is considered by many as a key enabling technology for the next-generation wireless networks operating in spectrum congested environments. C-STAR allows transmitting (TX) and receiving (RX) at the same ...


Isolation Enhancement For Cylindrical Structure Millimeter-Wave Repeaters, Brad Frank Allen Apr 2018

Isolation Enhancement For Cylindrical Structure Millimeter-Wave Repeaters, Brad Frank Allen

Electrical, Computer & Energy Engineering Graduate Theses & Dissertations

In radio frequency (RF), microwave, and millimeter wave (mmw) repeater applications, the receiver (RX) often needs to detect small power levels while simultaneously transmitting (TX) the same signal amplified significantly without distorting the incoming signal. In some applications, this can be done with time division or frequency division duplexing techniques; however, there are full duplex repeater applications that require simultaneous transmit and receive at the same time and same frequency. These full duplex systems often face the challenge of self-interference caused by the transmitter (TX to RX isolation).

This thesis focuses on enhancing the isolation between two antennas on a ...


Overcoming Limitations In Semiconductor Alloy Design, Theresa M. Christian Feb 2018

Overcoming Limitations In Semiconductor Alloy Design, Theresa M. Christian

Physics Graduate Theses & Dissertations

Inorganic semiconductors provide an astonishingly versatile, robust, and efficient platform for optoelectronic energy conversion devices. However, conventional alloys and growth regimes face materials challenges that restrict the full potential of these devices. Novel alloy designs based on isoelectronic co-doping, metamorphic growth and controllable atomic ordering offer new pathways to practical and ultra-high-efficiency optoelectronic devices including solar cells and light-emitting diodes.

Abnormal isoelectronic alloys of GaP1-xBix, GaP1-x-yBixNy, and GaAs1-xBix with unprecedented bismuth incorporation fractions and crystalline quality are explored in this thesis research. Comparative studies of several GaP1-xBi ...


High Frequency Dc-Dc Power Conversion For Automotive Led Driver Applications, Alihossein Sepahvand Feb 2018

High Frequency Dc-Dc Power Conversion For Automotive Led Driver Applications, Alihossein Sepahvand

Electrical, Computer & Energy Engineering Graduate Theses & Dissertations

This thesis studies high frequency dc-dc power converters for automotive LED driver applications. A high-frequency zero voltage switching (ZVS) integrated-magnetics Ćuk converter is well-suited for automotive LED-driver applications. In this converter, the input and output filter inductors and the transformer are realized on a single magnetic structure, resulting in very low input and output current ripples, thus reducing electromagnetic interference (EMI) and minimizing the required input and output filter capacitances. Active-clamp snubbers are used to mitigate the effects of the transformer leakage inductance. A prototype 1.8~MHz Ćuk converter with integrated magnetics is designed, built and tested. The prototype ...


Thermal Fusion For Sutureless Closure: Devices, Composition, Methods, Eric Anthony Kramer Jan 2018

Thermal Fusion For Sutureless Closure: Devices, Composition, Methods, Eric Anthony Kramer

Mechanical Engineering Graduate Theses & Dissertations

As minimally invasive surgical techniques progress, the demand for reliable ligation is pronounced. The surgical advantages of energy-based vessel sealing exceed those of traditional, compression-based ligatures in procedures sensitive to duration, foreign bodies, and recovery time alike. While the use of energy-based devices to seal or transect vasculature and connective tissue bundles is widespread, the breadth of heating strategies and energy dosimetry used between devices underscores an uncertainty as to the molecular nature of the sealing mechanism and induced tissue bond. Further, energy-based techniques (e.g., tissue “fusion” or tissue “welding”) exhibit promise for the closure, repair and functional recovery ...


Arm-First Synthesis Of Star Polymers With Wedge Polymer Arms Using Ring-Opening Metathesis Polymerization And Bifunctional Crosslinkers, Robert Whitson Learsch Jan 2018

Arm-First Synthesis Of Star Polymers With Wedge Polymer Arms Using Ring-Opening Metathesis Polymerization And Bifunctional Crosslinkers, Robert Whitson Learsch

Materials Science & Engineering Graduate Theses & Dissertations

Recently, wedge polymers with high molecular weight, size, and rigidity have been designed and synthesized. To date, the complexity of wedge polymers has been limited to the diblock copolymer architecture. This work presents a two-step, one-pot process to make star polymers with wedge polymer arms. After the wedge polymer arms are synthesized, crosslinker species are added to the reaction, rapidly forming star polymers. Crosslinker species with different conformational freedom were designed and synthesized and their performance was evaluated. Mass conversion up to 92% and stars with up to 17 arms were synthesized with the most rigid crosslinker. The effects of ...


Model Identification And Control Of Autonomous Ground Vehicles, Sina Aghli Jan 2018

Model Identification And Control Of Autonomous Ground Vehicles, Sina Aghli

Computer Science Graduate Theses & Dissertations

Autonomous Ground Vehicles (AGV) are mobile robotic platforms used in variety of applications to execute tasks which could be dangerous for humans to operate. Recently, autonomous cars are discussed in carrying passengers from point to point without human interaction. Sophisticated controllers are required to operate autonomous vehicles while responding to both normal and hazardous driving conditions. Dangerous conditions which might be easily perceivable by sensors in the system require controllers that can readily benefit from the new sensory information. In this thesis, we address this problem by asserting that the design of controllers and corresponding calibration and local planning methods ...


Skeletal Muscle Metabolism: From Tissue To Stem Cell, Katherine Elise Gadek Jan 2018

Skeletal Muscle Metabolism: From Tissue To Stem Cell, Katherine Elise Gadek

Molecular, Cellular, and Developmental Biology Graduate Theses & Dissertations

Excessive circulating triglycerides due to reduction or loss of lipoprotein lipase (LPL) activity contribute to hypertriglyceridemia and increased risk for pancreatitis. The only gene therapy treatment for LPL deficiency decreases pancreatitis but minimally reduces hypertriglyceridemia. Synthesized in striated muscle and adipose tissue, LPL is then trafficked to blood vessel endothelial cells where it hydrolyzes triglycerides into free fatty acids. We conditionally knocked out LPL in differentiated striated muscle tissue lowering striated muscle LPL activity and causing hypertriglyceridemia. We crossed these LPL knockout mice with mice possessing a conditional avian retroviral receptor gene and infected mice with human LPL or mCherry ...


Propagation And Control Of Geometric Variation In Engineering Structural Design And Analysis, Joseph David Benzaken Jan 2018

Propagation And Control Of Geometric Variation In Engineering Structural Design And Analysis, Joseph David Benzaken

Applied Mathematics Graduate Theses & Dissertations

In this dissertation, we present a methodology for understanding the propagation and control of geometric variation in engineering design and analysis. This work is comprised of two major components: (i) novel discretizations and associated solution strategies for rapid numerical solution over geometric parametrizations of the linear and nonlinear thin-shell equations, and (ii) efficient surrogate modeling techniques and algorithms towards the control of geometric variation. While the methodologies presented are in the setting of structural mechanics, particularly Nitsche's method in the context of linearized membranes, Kirchhoff-Love plates, and Kirchhoff-Love shells, they are applicable to any system of parametric partial differential ...


Finite-Volumes Based Fdtd Material Dispersion Modeling, Neeti Prakash Sonth Jan 2018

Finite-Volumes Based Fdtd Material Dispersion Modeling, Neeti Prakash Sonth

Electrical Engineering Graduate Theses & Dissertations

The conventional FDTD, based on second-order central difference formula, is useful only so long as the electrical size of the structure is small. Phase error accumulates in the field calculations as the dimensions of the numerical FDTD lattice become larger. The Finite Volumes-Based 3-D second-order in time, fourth-order in space (FV24) modeling is highly capable of controlling such phase errors. Therefore, it is suitable for electrically large problems at coarse grid resolutions.

This work models the frequency dependence of material losses using an Auxiliary Differential Equation (ADE), a technique extensively discussed in the literature. (Elsherbeni and Demir, 2016.) To account ...


Excited-State Dynamics Of Semiconductor Nanocrystals: Trapped-Hole Diffusion And Electron-Transfer Kinetics In Cds And Cdse Nanorods, James Keller Utterback Jan 2018

Excited-State Dynamics Of Semiconductor Nanocrystals: Trapped-Hole Diffusion And Electron-Transfer Kinetics In Cds And Cdse Nanorods, James Keller Utterback

Chemistry & Biochemistry Graduate Theses & Dissertations

Colloidal semiconductor nanocrystals have many remarkable properties—such as exceptionally tunable excited states and surface chemistry—that have led to an enthusiastic interest in using them for optoelectronic applications such as solar-energy conversion. Such technologies require control over the generation, separation, and extraction of photoexcited electrons and holes. However, the interpretation of experimentally measured excited-state decay curves is challenging because they typically exhibit complicated shapes that are elusive to simple kinetic models. To understand the principles that govern electron and hole relaxation dynamics in these complex systems, models rooted in fundamental physical phenomena are needed. This dissertation describes efforts to ...


Application Of Advances In Synthetic Biology To Modular Megasynthase Design And Scalable Combinatorial Biosynthesis, William Clifford Grau Jan 2018

Application Of Advances In Synthetic Biology To Modular Megasynthase Design And Scalable Combinatorial Biosynthesis, William Clifford Grau

Chemistry & Biochemistry Graduate Theses & Dissertations

The diversity in structure and biological activity of natural products has long captured the imagination of chemists and molecular biologists alike. Natural products are synthesized by elaborate secondary metabolic pathways or enzymes. For example, modular megasynthases such as Type I Polyketide Synthases (PKSs), Non-ribosomal Peptide Synthetases (NRPSs), and PKS-NRPS hybrids, produce an array of quintessential natural products. The apparent modularity, defined architecture, and predictable chemistry of modular megasynthases make them especially attractive for combinatorial biosynthesis, which has long been a focus of biotechnology. Combinatorial biosynthetic libraries are of particular interest due to the high value of many natural products and ...


Program Synthesis For Software-Defined Networking, Jedidiah Mcclurg Jan 2018

Program Synthesis For Software-Defined Networking, Jedidiah Mcclurg

Computer Science Graduate Theses & Dissertations

Software-defined networking (SDN) is revolutionizing the networking industry, but even the most advanced SDN programming platforms lack mechanisms for changing the global configuration (the set of all forwarding rules on the switches) correctly and automatically. This seemingly-simple notion of global configuration change (known as a network update) can be quite challenging for SDN programmers to implement by hand, because networks are distributed systems with hundreds or thousands of interacting nodes---even if the initial and final configurations are correct, naïvely updating individual nodes can lead to bugs in the intermediate configurations. Additionally, SDN programs must simultaneously describe both static forwarding behavior ...