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Full-Text Articles in Engineering

Characterizing Targeted Therapeutic Delivery And Cellular Dynamics Using In Vitro Cancer Disease Models, Christopher George Uhl Aug 2018

Characterizing Targeted Therapeutic Delivery And Cellular Dynamics Using In Vitro Cancer Disease Models, Christopher George Uhl

Theses and Dissertations

Cancer is a significant health risk to people living in developed and developing countries, which continues to prove difficult to treat. Common treatment options of cancers include surgical removal, radiation, and chemotherapies, which are often used in combination to improve the likelihood of successful treatment. Such combinatory approaches towards treatment are often taken because each approach is not targeted enough to function perfectly on its own. Being able to delivery therapeutic loads in a more targeted manner to sites of cancer has the capability of improving therapeutic efficiency and improving patient responses. The development of improved therapeutic delivery vehicles and ...


Isolation Of Circulating Tumor Cells And Clusters From Blood With Application In Drug Screening, Wentao Shi Jan 2018

Isolation Of Circulating Tumor Cells And Clusters From Blood With Application In Drug Screening, Wentao Shi

Theses and Dissertations

Circulating tumor cell (CTC) plays a significant role to lead tumor become life-threatening. The appearance of CTC in the circulating system of tumor patients is deemed as the start of metastasis. To obtain CTC from blood is critical for vast biomedical applications, such as using CTC for DNA sequencing to reveal the gene difference between CTC and tumor cells at original site, creating in vitro tumor models based on CTC, and develop new and effective therapeutic schemes, etc. Based on this, the focus of the dissertation mainly on the research towards CTC. In brief, the dissertation demonstrates several techniques on ...


Rheological Properties Of Colloidal And Polymeric Scaffolds Measured Using Multiple Particle Tracking Microrheology, Matthew David Wehrman Jan 2018

Rheological Properties Of Colloidal And Polymeric Scaffolds Measured Using Multiple Particle Tracking Microrheology, Matthew David Wehrman

Theses and Dissertations

Characterizing the rheological properties of polymeric and colloidal gels during dynamic phase transitions is critical in developing targeted products for industrial and home care use. These materials require specific rheology that allow them to respond to external stimuli. The goal of this work is to characterize the rheological properties of polymeric and fibrous colloidal gels throughout gelation, degradation, and at equilibrium to infer their microstructure. An emphasis is made on hydrogenated castor oil (HCO), a fibrous colloid that undergoes heterogenous phase transitions and is subject to changes in microstructure when sheared during sample preparation. We use multiple particle tracking (MPT ...


Digital-Lithographic Fabrication Of Unconventional 3d Microstructures, Ran He Jan 2017

Digital-Lithographic Fabrication Of Unconventional 3d Microstructures, Ran He

Theses and Dissertations

Developing advanced microfabrication technologies have been regarded as an important direction since many opportunities in technological innovations depend on the ability to fabricate novel structures in microscale. Commercially, high-throughput devices fabricated by cost-effective and efficient techniques that are suitable for mass production are highly desired. Scientifically, the ability to generate unconventional microstructures for improving the design and control experiments has attracted great interest of scientists. This dissertation presents five innovative techniques based on digital-lithographic fabrication to generate unconventional structures as better solutions in various applications. The techniques were firstly developed to advance the microfluidic areas, and then extended to 3D ...


Characterizing Targeted Drug Delivery And Endothelial Cell Dynamics Using In Vitro Blood Vessel Models, Antony Thomas Jan 2015

Characterizing Targeted Drug Delivery And Endothelial Cell Dynamics Using In Vitro Blood Vessel Models, Antony Thomas

Theses and Dissertations

Endothelial cells form the inner lining of blood vessels and regulate key blood vessel functions including host defense reactions, vascular smooth muscle tone, angiogenesis, and tissue fluid homeostasis. The occurrence of a pathological condition can lead to inflammation, a protective and tightly regulated response involving host cells, blood vessels and proteins. This process is promoted by circulating cytokines and other chemical mediators such as tumor necrosis factor-alpha (TNF-α), interleukins, thrombin, a few examples. Inflammation can be acute or chronic in nature and is characterized by specific cell receptor expression patterns on the endothelial layer and an increase in endothelial cell-cell ...