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Full-Text Articles in Engineering

Multi-Layer Shotcrete Design For Tunnel Construction, Bruno Mattle, Wolfgang Summerer, Sebastian Höser, Vladimír Bartoš Dec 2018

Multi-Layer Shotcrete Design For Tunnel Construction, Bruno Mattle, Wolfgang Summerer, Sebastian Höser, Vladimír Bartoš

Shotcrete for Underground Support XIII: New Developments in Rock Engineering, Tunneling, Underground Space and Deep Excavation

No abstract provided.


Single-Use And Sustainability: Continued Studies Using Lca Tools, William Whitford Sep 2018

Single-Use And Sustainability: Continued Studies Using Lca Tools, William Whitford

Single-Use Technologies III: Scientific and Technological Advancements

The issue of plastic materials in our environment has been of recent interest. The biotechnology community has responded by examining the effects of single-use systems employed in biomanufacturing. It is natural to emphasize a particular set of environmental concerns over others, and especially the more visible ones. But, in supporting truly sustainable manufacturing systems, it is important to consider all relevant types of pollution or environmental stress. The Life Cycle Assessment (LCA) is a science-based approach for evaluating the environmental impacts, benefits, trade-offs, and burden shifts of a process in an objective format. It considers production process’ materials, equipment and ...


Comparison Of Single-Use And Steel Fermenters For Kla And Aggressive Microbial Cultures, Jason Brown, Christopher Brau, Nephi Jones Sep 2018

Comparison Of Single-Use And Steel Fermenters For Kla And Aggressive Microbial Cultures, Jason Brown, Christopher Brau, Nephi Jones

Single-Use Technologies III: Scientific and Technological Advancements

Purpose built single-use fermenters enable production facilities to utilize the single-use technologies instead of traditional stainless steel fermentor vessels without modifying their existing procedures. The manufacture lead time of the single-use fermentor hardware is a fraction of traditional vessels. As each single-use bioprocess container ships sterile and validated, reducing down time between cultures and allowing for more production volume in less space. Here we demonstrate kLa studies and aerobic cultivations with up to 2vvm gas flow in comparison of the single-use fermentors to traditional stainless steel fermenters. These single-use fermentors covering 6L-300L working volumes are specifically designed to meet the ...


Continuous Process Performance Enhancements For 50-500 L S.U.B.S, Ben Madsen, Jordan Cobia, Nephi Jones, Kevin Mullen Sep 2018

Continuous Process Performance Enhancements For 50-500 L S.U.B.S, Ben Madsen, Jordan Cobia, Nephi Jones, Kevin Mullen

Single-Use Technologies III: Scientific and Technological Advancements

Improvements in single-use systems have allowed implementation of high-density cultures in emerging bioprocess workflows while progressive advances in media optimization and improved clone genetic selection have underscored the perceived performance limitations of single-use bioreactors (S.U.B.s). This study presents how strategic enhancements to the sparge and agitation systems of Thermo Scientific™ HyPerforma™ S.U.B.s have revealed the potential for a three- to four-fold improvement of mixing and mass transfer performance compared to legacy SUB designs. This study investigates the following:

  • Bioreactor characterization, TruBio™ DeltaV™ controller optimization, online process analytics, and scalability analysis of the S.U ...


Polymer Interfaces And Biopharmaceuticals: Chemistry, Designs And Challenges, David W. Grainger Sep 2018

Polymer Interfaces And Biopharmaceuticals: Chemistry, Designs And Challenges, David W. Grainger

Single-Use Technologies III: Scientific and Technological Advancements

The complex interactions between biological components and polymer materials has an extensive technical history. Virtually every surface property has been invoked as being important to biological interfacial response: texture, roughness, topology, porosity, hydrophilic, hydrophobic, polar, apolar, (non)-wettable, non-fouling brushes, surface mobility, rigidity, flexibility, crystalline versus amorphous, aspect ratio. Few surface properties alone, however, provide consistent, global technical solutions to vexing biomedical technology problems, particularly with cell culture, blood, plasma, microbial milieu, and protein solutions. Bio-interface materials performance must therefore be tailored specifically to each application. Short-term contact use (minutes/hours) has different materials interface requirements than long-term (days) use ...


Automated Foam Control In Single-Use Bioreactors Using The Single Use Foam Probe, Jordan Cobia, Ben Madsen, Emilee Madsen, Alex Hodge Sep 2018

Automated Foam Control In Single-Use Bioreactors Using The Single Use Foam Probe, Jordan Cobia, Ben Madsen, Emilee Madsen, Alex Hodge

Single-Use Technologies III: Scientific and Technological Advancements

Headspace foam in bioreactors can cause significant issues to a biological process among which are unfavorable metabolic conditions for cells, increased shear from bursting bubbles, cell death/entrainment, mass transfer interference and potential fouling of exhaust filters which can allow a point of entry for contamination or lead to pressure build-up and possible failure of the bioprocess container. This study investigates the efficacy of using a single use foam probe coupled with an automated response of an antifoam addition with an integrated DeltaV controller. Two 50L S.U.B.s run in parallel clearly illustrate differences; the first employing foam ...


Ph Evolution In Solution After Contact With Multilayer Films After Different G- Irradiation Doses And Thus Reconciliation Of Ph And Toc With Carboxylic Acids Detected By Ion Chromatography, Samuel Dorey, Fanny Gaston, Nathalie Dupuy, Magali Barbaroux, Sylvain R.A. Marque Sep 2018

Ph Evolution In Solution After Contact With Multilayer Films After Different G- Irradiation Doses And Thus Reconciliation Of Ph And Toc With Carboxylic Acids Detected By Ion Chromatography, Samuel Dorey, Fanny Gaston, Nathalie Dupuy, Magali Barbaroux, Sylvain R.A. Marque

Single-Use Technologies III: Scientific and Technological Advancements

For a number of various uses (storage, mixing, freezing, transportation, formulation, and filling) biopharmaceutical solutions are stored in sterile single-use plastic bags. Material transfers can then occur between containers and contents. These migrations, of different types, depend on the physicochemical characteristics of the material (composition, pH, solubility, viscosity, molecular weight, etc.), the nature of the product (solid, semi-solid and liquid) and the conditions of the material utilization. In the case of single-use polymers, γ-irradiation sterilization of the polymer is often carried out. The interactions could be therefore influenced by the dose and the contact time between the container and the ...


Single-Use Ph Sensor Via A Coplanar Ph Glass Electrode Design, Cd Feng, Robert Garrahy Sep 2018

Single-Use Ph Sensor Via A Coplanar Ph Glass Electrode Design, Cd Feng, Robert Garrahy

Single-Use Technologies III: Scientific and Technological Advancements

The elimination of high temperature and high pressure sterilization processes by the advent of Single-Use-Systems (SUS) opens up a new era for the glass electrode based pH sensor. Without the requirement for pretreatment of a pH glass electrode under high temperature and pressure, the classic pH sensing technology delivers a more reliable, more rugged, and more accurate pH measurement. However, the innovative and unique SUS practice also posts new challenges, such as the long shelf-life requirement and the limitation of access to the sensor for calibration once on site,.

At Broadley-James Corporation, a new manufacturing technology has been developed to ...


The Proper Use Of Extractables Data - Aspects Beyond Extractables-Measurment, Samuel Dorey, Armin Hauk, Roberto Menzel, Thomas Loewe, Ina Pahl Sep 2018

The Proper Use Of Extractables Data - Aspects Beyond Extractables-Measurment, Samuel Dorey, Armin Hauk, Roberto Menzel, Thomas Loewe, Ina Pahl

Single-Use Technologies III: Scientific and Technological Advancements

Appropriate extraction techniques for SUS/SUT and methods for analysis of extractables have been intensively discussed over the last years. Today, several proposals for common methods are available and used to conduct extractables studies in the bio-pharmaceutical industry. Therefore it is expected that the number of available extractables data will significantly rise over the next years and it is worth to (re-)consider their proper use for materials and device qualification and risk assessment. While this exercise is straightforward for container closure systems (CCS), for SUS/SUT the situation is more complex. In CCS applications, a single drug product, in ...


Tuflux Tpe Tubing For Pharma Processing, Pradnya Parulekar, Michael Drechsel Sep 2018

Tuflux Tpe Tubing For Pharma Processing, Pradnya Parulekar, Michael Drechsel

Single-Use Technologies III: Scientific and Technological Advancements

The guidelines for launching new products and manufacturing those approved products are becoming more stringent on a routine basis. Quality certifications, clean room requirements, forwards and backwards traceability on all components are the new standard for providing FDA-approve products. Part of insuring that quality criteria are being met is to understand how the raw material is created, how it is processed in to a technologically useful processing aid (tube) and then how is that tube tested. Thermoplastic resin is the key ingredient in creating TuFlux tubing. The broad chemistry footprint allows specialized compounders to create unique blends of components (using ...


Purity Testing Protocols For Silicone Tubing, Csilla Kollar, Lise Tan-Sien-Hee Sep 2018

Purity Testing Protocols For Silicone Tubing, Csilla Kollar, Lise Tan-Sien-Hee

Single-Use Technologies III: Scientific and Technological Advancements

Silicone tubing products are widely used in critical biopharmaceutical processes including final fill and other aseptic operations that require high purity product contact components.

At Dow we have developed reliable and rigorous methods based on the industry standards for particulates, endotoxins and bioburden to test our Platinum-catalyzed silicone tubing family. The tests were conducted per the USP ‹788› Particulate Matter in Injection, the USP ‹85› Bacterial Endotoxins Test, and the ISO 11737-1 Sterilization of medical devices — Microbiological methods — Part 1: Determination of a population of microorganisms on products.

  • Method 2 Microscopic Particle Count Test of USP ‹788› was used to ...


Process Intensification In Biomanufacturing Driven By Advances In Single Use Technologies, Stefan Schmidt Sep 2018

Process Intensification In Biomanufacturing Driven By Advances In Single Use Technologies, Stefan Schmidt

Single-Use Technologies III: Scientific and Technological Advancements

Single use technologies now represent the state of the art in biomanufacturing, but still the full potential of a broad application has not been tapped yet. One strategy that captures most of disposable benefits is process intensification. Here single use systems are optimized to achieve similar output levels as traditional stainless-steel facilities but at much lower capital expenditure, smaller footprints and faster implementation times. This presentation gives an overview on current approaches, describes the opportunities and limits of disposables and delivers recommendations to what should be done by suppliers and users in the near future.


Conference Program, Weibing Ding, Martina Micheletti, Robert Repetto Sep 2018

Conference Program, Weibing Ding, Martina Micheletti, Robert Repetto

Single-Use Technologies III: Scientific and Technological Advancements

No abstract provided.


An Example Of Thermoset – Silicone, Csilla Kollar Sep 2018

An Example Of Thermoset – Silicone, Csilla Kollar

Single-Use Technologies III: Scientific and Technological Advancements

Abstract is not available.


Mixing Operations For 50 L To 2000 L Single-Use Mixer: Liquid-Liquid Mixing Characterization And Slurry Suspension, Jordan Cobia, Kevin Mullen, Becky Staerk Sep 2018

Mixing Operations For 50 L To 2000 L Single-Use Mixer: Liquid-Liquid Mixing Characterization And Slurry Suspension, Jordan Cobia, Kevin Mullen, Becky Staerk

Single-Use Technologies III: Scientific and Technological Advancements

Mixers are employed throughout all parts of bioprocessing. Single-use mixers (S.U.M.) are commonly used for upstream operations including media formulation and hydration, media holding, sterile filtration and downstream operations including media and product storage, viral inactivation, buffer preparation, and resin/slurry preparation for column packing. This study presents the automation of both simple and complex mixing procedures using the Thermo Fisher Touchscreen Control Panel. Also investigated are the selection method for scalable mixing parameters allowing normalized mixing performance across all single use mixer sizes. The following applications are demonstrated in this study:

  • Characterization of scalable mixing parameters by ...


Qualification Of Low Drift Single-Use Ph Sensors For Use In Single-Use Bioreactor Platforms, Jason Brown, Alexander J. Hodge, Nephi Jones Sep 2018

Qualification Of Low Drift Single-Use Ph Sensors For Use In Single-Use Bioreactor Platforms, Jason Brown, Alexander J. Hodge, Nephi Jones

Single-Use Technologies III: Scientific and Technological Advancements

The biopharmaceutical industry is currently limited by access to low drift, gamma stable, easy-to-integrate single-use pH sensors for application in single-use bioreactors (S.U.B.). Hamilton Company has developed the OneFerm VP 70 sensor, a unique single-use glass electrode, which provides an additional option for customers wishing to implement reliable single-use pH sensing capabilities in the S.U.B. platform. In order to demonstrate the efficacy of these devices, a series of qualification experiments were carried out using a Thermo Fisher Scientific 50L bioprocess container (BPC) custom-fitted with Hamilton OneFerm sensors. BPCs were manufactured in a cGMP facility and allowed ...


Advanced Rheological And Tribological Methods For Cosmetic Products, Joerg Laeuger Jul 2018

Advanced Rheological And Tribological Methods For Cosmetic Products, Joerg Laeuger

Advances in Cosmetic Formulation Design

Many different rheological procedures can used to tailor cosmetic products in a way that they meet the desired properties. Simple flow curve measurements reveal the viscosity at shear rates prevailing at processing conditions. Strain sweep give information on the strength of the rest structure and the amount of elasticity. The end of the linear visco-elastic range which is measured in a strain sweep is in a direct correlation to with the yield stress and flow point which need to be overcome in order that a gel like material starts to flow. A frequency sweep can help to gain information on ...


Sensory Kaleidoscope – Taking Skin Feel To The Next Level Taking Sensory From Nature, Anna Howe, Anne Mu, Brian Yang Jul 2018

Sensory Kaleidoscope – Taking Skin Feel To The Next Level Taking Sensory From Nature, Anna Howe, Anne Mu, Brian Yang

Advances in Cosmetic Formulation Design

The skin feel of a cosmetic formulation is one of the drives for consumers’ purchase decision and loyalty to care products. Traditionally, skin sensory evaluations on various attributes are often conducted in comparison among prototypes to predict/screen winning formulations with high probability of consumers’ acceptance. However, due to the large number of sensory attributes, it is a challenge to compare several products/formulations of interests with all attributes in one chart. A new interactive tool, developed by Evonik, using a scientific approach to describe and understand the skin sensory profiles, allows simple comparison of formulations in one chart. It ...


Natsurfact: Progress In Commercializing Rhamnolipids, Daniel Derr Jul 2018

Natsurfact: Progress In Commercializing Rhamnolipids, Daniel Derr

Advances in Cosmetic Formulation Design

NatSurFact is a rhamnolipid-based biosurfactant ingredient for the cosmetics industry developed by Logos Technologies. Rhamnolipids are a member of the glycolipid class of biosurfactants. They are made up of a rhamnose sugar head group and medium chain length 3-hydroxy fatty acid tails. Their structure was first elucidated in 1949 and they have been studied for myriad applications both academically and commercially since. While their properties as an anionic surfactant in the salt form are attractive – natural, mild, high foaming, high cleansing – they are not sold yet in appreciable commercial quantities. To bring rhamnolipids to market, Logos has focused on efficient ...


Novel High-Performance Ingredients Based On Functionalized Polysaccharides – The Role Of Enzymatic Catalysis., Stefan Ulvenlund Jul 2018

Novel High-Performance Ingredients Based On Functionalized Polysaccharides – The Role Of Enzymatic Catalysis., Stefan Ulvenlund

Advances in Cosmetic Formulation Design

Polysaccharides are interesting starting materials in the design of high-performance cosmetic ingredients, not only because of their generally low toxicity and “green” profile, but also because of their wide and exciting propensity to form complex self-aggregated structures. These structures have direct relevance for formulation science, since they provide us with the means to tailor and optimize rheological characteristics, solubilization efficiency, emulsification and other critical attributes of a formulation. However, in order to fully exploit this potential of polysaccharide-based materials we need not only the ability to extract, purify and refine them on an industrial scale. We also need cost-efficient tools ...


Structural, Nanomechanical, And Nanotribological Characterization Of Human Hair And Conditioner Using Atomic Force Microscopy And Nanoindentation, Bharat Bhushan Jul 2018

Structural, Nanomechanical, And Nanotribological Characterization Of Human Hair And Conditioner Using Atomic Force Microscopy And Nanoindentation, Bharat Bhushan

Advances in Cosmetic Formulation Design

Human hair is a nanocomposite biological fiber. Maintaining the health, feel, shine, color, softness, and overall aesthetics of the hair is highly desired. Hair care products such as shampoos and conditioners, along with damaging processes such as chemical dyeing and permanent wave treatments, affect the maintenance and grooming process and are important to study because they alter many hair properties. Nanoscale characterization of the cellular structure, mechanical properties, and morphological, frictional, and adhesive properties (tribological properties) of hair are essential to evaluate and develop better cosmetic products, and to advance the understanding of biological and cosmetic science. The tensile response ...


Sulfate Free Solutions For Personal Care Applications, Prabhjyot Singh Jul 2018

Sulfate Free Solutions For Personal Care Applications, Prabhjyot Singh

Advances in Cosmetic Formulation Design

The personal care market is driven by consumer needs, where natural ingredients, safety awareness and free- from claims are main drivers. Free-from claims are continuing to grow and sulfate-free is a leading claim for this trend, particularly in the shampoo and body wash market. Sulfate-free cleansers are growing more than 8% CAGR. Sulfate- free surfactants present many challenges in product performance in comparison to sulfates, mainly in providing efficient thickening and desirable sensory and lather performance. Another challenge is to meet the crucial needs of the formulator by providing ingredients that are sustainable, able to be cold processed and delivered ...


Conference Program, Samiul Amin, Ponisseril Somasundaran Jul 2018

Conference Program, Samiul Amin, Ponisseril Somasundaran

Advances in Cosmetic Formulation Design

No abstract provided.


Compound Design Process - To A Better Start, Aurora Costache, Gabor Imre, Ivan Solt, Akos Tarcsay, Aurora Costache Jul 2018

Compound Design Process - To A Better Start, Aurora Costache, Gabor Imre, Ivan Solt, Akos Tarcsay, Aurora Costache

Advances in Cosmetic Formulation Design

Molecule and formulation design is an information demanding activity, since all relevant knowledge is to be accessible within a single space and requires synchronized application of computational models to assist decision making on synthesis candidates. Our study aims to evaluate a software platform coping with this complexity (Marvin Live). The tool provides central management of innovative ideas and helps triage them based on predicted properties and available knowledge collected from a variety of sources. The calculated properties span physico-chemical descriptors, combined metrics, 3D overlay and modelling results, with the ability to check if they are compliant with local and international ...


Examination Of Factors Influencing Fcg In Legacy Aluminum Alloys, Sarah E. Galyon Dorman, Scott A Fawaz, Justin W Rausch Jul 2018

Examination Of Factors Influencing Fcg In Legacy Aluminum Alloys, Sarah E. Galyon Dorman, Scott A Fawaz, Justin W Rausch

Stress-Assisted Corrosion Damage V

In work sponsored by the Office of Naval Research a corrosion fatigue test method to better replicate real world corrosion conditions using salt film, relative humidity, ozone and UV-light, is being developed [1]. This method is being used to evaluate the effect of atmospheric corrosion conditions in AA7075-T651 with inhibitive coatings including epoxy chromate and three chromate replacement coatings (water and epoxy based rare earth primers and an aluminum rich primer). The corrosion fatigue results are being paired with leaching studies under traditional immersion and atmospheric conditions on the primers to determine how the leaching rates relate to the ability ...


Transition From Small To Large Cracks In Ti-6al-4v Specimens, Emanuele Vincenzo Arcieri, Sergio Baragetti, Emanuele Borzini Jul 2018

Transition From Small To Large Cracks In Ti-6al-4v Specimens, Emanuele Vincenzo Arcieri, Sergio Baragetti, Emanuele Borzini

Stress-Assisted Corrosion Damage V

Light alloys allow us to have light components with interesting mechanical features. Ti-6Al-4V is a bimodal titanium alloy employed in aerospace, automotive, maritime and biomedical applications. This alloy has also a good corrosion strength which can be reduced by damages on the passivating surface layer. These damages can be due to an inadequate adhesion of the surface layer, variable loads and interactions with aggressive media [1,2].

For these reasons, quasi-static and fatigue tests on Ti-6Al-4V specimens in different inert, aggressive and very aggressive environments were carried out in the past. Air, air + beeswax coating, paraffin oil, 3.5wt.% NaCl-water ...


Investigation Of Scc Of High Strength Aluminum Alloys By Means Of Slow Strain Rate Test And Cyclic Anodic Polarization In Combination, Monica Trueba, Guido Russo, Stefano P. Trasatti, Sergio Lorenzi, Marina Cabrini, Antonietta Loconte Jul 2018

Investigation Of Scc Of High Strength Aluminum Alloys By Means Of Slow Strain Rate Test And Cyclic Anodic Polarization In Combination, Monica Trueba, Guido Russo, Stefano P. Trasatti, Sergio Lorenzi, Marina Cabrini, Antonietta Loconte

Stress-Assisted Corrosion Damage V

The stress corrosion cracking (SCC) behavior of high strength 7075-T6 and 2024-T3 Al alloys in NaCl solutions is investigated by means of slow strain rate test (SSRT) and cyclic anodic polarization in combination. Smooth, dog-bone shaped flat tension test specimens, having gage section areas of 40 mm2 and 32 mm2, respectively, and 90 mm of gage length, were machined in the longitudinal (rolling) direction from the commercial wrought sheets (Aviometal Spa). The tensile test was performed at a constant strain rate (ἐ = 10-7, 10-6 or 10-5 s-1) from a pre-load of about 5 kN ...


Effect Of Cyclic Loading On Hydrogen Diffusion In Low Carbon Steels, Diego Pesenti Bucella, Lorenzi S, Pastore T, Cabrini M. Jul 2018

Effect Of Cyclic Loading On Hydrogen Diffusion In Low Carbon Steels, Diego Pesenti Bucella, Lorenzi S, Pastore T, Cabrini M.

Stress-Assisted Corrosion Damage V

Carbon steels or low-alloyed steels may be affected by damaging phenomena due to Hydrogen Embrittlement (HE), which is a particular form of Environmental Assisted Cracking (EAC). The insurgence of HE depends on the intrinsic susceptibility of the steel, the applied stress, and the concentration of hydrogen inside the metal. It occurs by a mechanism of absorption and subsequent diffusion of atomic hydrogen through the metal lattice.

On steels with a yield strength lower than 700 MPa, HE occurs in the plastic deformation field, in the presence of dynamic loading at slow strain rates or cyclic fatigue loading at very low ...


Short Crack Tolerance Under Eac Conditions, Jtp Castro, Rv Landin, In Viçosa, Gr Altoé, Rrc Saúde Jul 2018

Short Crack Tolerance Under Eac Conditions, Jtp Castro, Rv Landin, In Viçosa, Gr Altoé, Rrc Saúde

Stress-Assisted Corrosion Damage V

Notch sensitivity effects under environmentally-assisted cracking (EAC) conditions have been recently quantified considering the tolerance to short cracks that may start at their tips and become non-propagating after growing for a while, a behavior that depends on the stress gradients ahead of the notch tips and on the basic material resistances to crack initiation (SEAC) and propagation (KIEAC) inside an aggressive medium under static loadings. Such properties are time-independent, so they can be directly compared with the notch gradient-affected stress intensity factors of the short cracks that depart from notch tips. This model can provide a powerful alternative ...


Conference Program, A.K. Vasudevan, Henry Holroyd, Ronald Latanision Jul 2018

Conference Program, A.K. Vasudevan, Henry Holroyd, Ronald Latanision

Stress-Assisted Corrosion Damage V

No abstract provided.