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Full-Text Articles in Engineering
Low Concentration Microenvironments Enhance The Migration Of Neonatal Cells Of Glial Lineage, Richard A. Able, Jr., Celestin Ngnabeuye, Cade Beck, Eric C. Holland, Maribel Vazquez
Low Concentration Microenvironments Enhance The Migration Of Neonatal Cells Of Glial Lineage, Richard A. Able, Jr., Celestin Ngnabeuye, Cade Beck, Eric C. Holland, Maribel Vazquez
Publications and Research
Glial tumors have demonstrated abilities to sustain growth via recruitment of glial progenitor cells (GPCs), which is believed to be driven by chemotactic cues. Previous studies have illustrated that mouse GPCs of different genetic backgrounds are able to replicate the dispersion pattern seen in the human disease. How GPCs with genetic backgrounds transformed by tumor paracrine signaling respond to extracellular cues via migration is largely unexplored, and remains a limiting factor in utilizing GPCs as therapeutic targets. In this study, we utilized a microfluidic device to examine the chemotaxis of three genetically-altered mouse GPC populations towards tumor conditioned media, as …
Calibration And Validation Of A Regional Climate Model For Pan-Arctic Hydrologic Simulation, Helin Wei, William J. Gutowski Jr., Charles J. Vörösmarty, Balazs M. Fekete
Calibration And Validation Of A Regional Climate Model For Pan-Arctic Hydrologic Simulation, Helin Wei, William J. Gutowski Jr., Charles J. Vörösmarty, Balazs M. Fekete
Advanced Science Research Center
A number of polar datasets have recently been released involving in situ measurements, satellite retrievals, and reanalysis output that provide new opportunities to evaluate regional climate in the Arctic. These data have been used to assess a 1-yr pan-Arctic simulation (October 1985–September 1986) performed by a version of the fifth-generation Pennsylvania State University–National Center for Atmospheric Research (PSU–NCAR) Mesoscale Model (MM5) that incorporated the NCAR land surface model (LSM) and a simple thermodynamic sea ice model to investigate interactions between the land surface and atmosphere. The model’s standard cloud scheme using relative humidity was replaced by one using simulated cloud …