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Full-Text Articles in Engineering

Energy Harvesting Sensors And Their Role In Fostering Sustainable Air Quality Monitoring, Tomas Valentin, Li Geng Dec 2023

Energy Harvesting Sensors And Their Role In Fostering Sustainable Air Quality Monitoring, Tomas Valentin, Li Geng

Publications and Research

This research presents a comprehensive investigation into Energy Harvesting Sensors and their role in fostering sustainable air quality monitoring. The primary objective is to explore the viability of energy harvesting technologies in energizing sensor networks devoted to the real-time collection of air quality data, emphasizing the reduction of environmental impact and maintenance demands. The study delves into the integration of energy harvesting mechanisms, including solar and piezoelectric kinetic energy, to power advanced sensor nodes capable of detecting pollutants, particulate matter, and gas concentrations. The findings of this research highlight the significant benefits of energy harvesting sensors, including enhanced sustainability, long-term …


The Utilization Of Repurposed Whole Textiles To Modify The Mechanical And Hydrogeological Soil Properties: Green Media, Angelis Almanzar-Chevalie, Yehya Elfgeeh, Calvin O. Walters Jr. Dec 2023

The Utilization Of Repurposed Whole Textiles To Modify The Mechanical And Hydrogeological Soil Properties: Green Media, Angelis Almanzar-Chevalie, Yehya Elfgeeh, Calvin O. Walters Jr.

Publications and Research

The utilization of repurposed whole textiles to modify the mechanical and hydrogeological soil properties investigates the impact of adding repurposed textiles to lightweight engineered soil, documenting changes in unit weight, water content, and hydraulic conductivity. This study builds upon prior findings, which demonstrated significant alterations in hydrogeological properties when incorporating textile fabric (3% by weight at an aspect ratio of 1:1). Functioning as reinforcement, these fibers enhance the soil's strength, stability, and structural integrity—especially advantageous in erosion-prone areas, regions susceptible to landslides, or locations requiring heightened load-bearing capacity. The outcomes of this parametric study lead to green roof farms playing …


Code To Combustion: Cnc Rotor Replication Using Cam, Luis Luna Dec 2023

Code To Combustion: Cnc Rotor Replication Using Cam, Luis Luna

Publications and Research

In the current landscape, computer-aided design (CAD) and computer numerical control (CNC) technologies have greatly enhanced manufacturing processes, allowing rapid and high-precision production. This project will focus on recreating a Wankel engine rotor, using SolidWorks for design and Mastercam for Computer-Aided Manufacturing (CAM) simulations. The process begins with SolidWorks, which is used for a template of a high-precision rotor model. Mastercam is then utilized for the CAM programming, allowing for the creation of intricate tool paths and tool usage simulations. This approach is vital for complex objects like the Wankel engine rotor, which demands high precision. The primary objective of …


Wettability Dynamics Of Kerogen: Insights From Molecular Dynamics Simulations On Thermal Maturity And Reservoir Temperature Impact, Wei Liang, Xin Chen, Rajat Sharma Dec 2023

Wettability Dynamics Of Kerogen: Insights From Molecular Dynamics Simulations On Thermal Maturity And Reservoir Temperature Impact, Wei Liang, Xin Chen, Rajat Sharma

Publications and Research

This comprehensive review explores the multifaceted role of kerogen in organic-rich mudrock reservoirs, focusing on its impact on porosity, hydrocarbon storage, and transport pathways. The dominance of kerogen-hosted pores is underscored as a critical determinant of reservoir dynamics, with an emphasis on the wettability of kerogen as a pivotal parameter. The intricate relationship between kerogen wettability and petrophysical properties, including water saturation and electromagnetic characteristics, is elucidated, emphasizing the broader implications for reservoir management and hydrocarbon recovery.

The study delves into the thermal maturation of kerogen, unraveling the chemical evolution from hydrogen-rich organic matter to hydrogen-poor residual carbon. The Van …


Compound Flooding In A Non-Stationary World: A Primer For Practice, Gerarda M. Shields, J. Rolf Olsen, Miguel Medina Jr., Jayantha Obeysekera, Poulomi Ganguli, Carlo Demichele, Gianfausto Salvadori, Mohammad Reza Najafi, Hamed Moftakhari, Ferdinand Diermanse, Amir Aghakouchak Nov 2023

Compound Flooding In A Non-Stationary World: A Primer For Practice, Gerarda M. Shields, J. Rolf Olsen, Miguel Medina Jr., Jayantha Obeysekera, Poulomi Ganguli, Carlo Demichele, Gianfausto Salvadori, Mohammad Reza Najafi, Hamed Moftakhari, Ferdinand Diermanse, Amir Aghakouchak

Publications and Research

Compound flooding conditions present a significant challenge for civil engineers in their pursuit to design for and maintain the integrity of a structure’s entire life cycle. Coupled with non-stationary processes due to a changing climate and land use change, risk is a moving target. Through the support of ASCE’s Task Committee on Compound Flooding, the Hydroclimatology Engineering Adaptation (HYDEA) sub-committee is developing a Manual of Practice (MOP) to provide a synthesis of available tools and methods of best practice for civil engineers designing for compound flooding conditions. This paper presents a primer for practicing civil engineers on this work. Hydrodynamic …


The Potential Of The Implementation Of Offline Robotic Programming Into Automation-Related Pedagogy, Max Rios Carballo, Xavier Brown Jun 2023

The Potential Of The Implementation Of Offline Robotic Programming Into Automation-Related Pedagogy, Max Rios Carballo, Xavier Brown

Publications and Research

In this study, the offline programming tool RoboDK is used to program industrial robots for the automation sector. The study explores the feasibility of using this non-disruptive robot programming software for classroom use; assesses how well RoboDK can be used to program various robots used in the industry; creates and tests various applications; and pinpoints technical obstacles that prevent a smooth link between offline programming and actual robots. Initial results indicate that RoboDK is an effective tool for deploying its offline programming code to a Universal Robot, UR3e. There are many potential for advanced applications. The goal of the project …


Development Of A Raspberry Pi-Controlled Vex Robot For A Robotics Technology Course, Lili Ma, Justin Bartholomew, Yu Wang, Xiaohai Li Jun 2023

Development Of A Raspberry Pi-Controlled Vex Robot For A Robotics Technology Course, Lili Ma, Justin Bartholomew, Yu Wang, Xiaohai Li

Publications and Research

This paper describes the development of a Raspberry PI-controlled VEX robot for an undergraduate robotic course. The Raspberry PI controls the mobile base built using the VEX robotics kit without using the Cortex micro-controller that comes with the kit. The aim is to create a physical robot that is manageable, easily replicable, and capable of performing advanced robotic control tasks such as vision-based control.

The constructed robot adopts the great features of the PI and the VEX hardware. Firstly, the VEX hardware consists of various sensors and actuators for students to practice the construction and assembly of an autonomous robot. …


Introducing Ros-Projects To Undergraduate Robotic Curriculum, Lili Ma, Yu Wang, Chen Xu, Xiaohai Li Jun 2023

Introducing Ros-Projects To Undergraduate Robotic Curriculum, Lili Ma, Yu Wang, Chen Xu, Xiaohai Li

Publications and Research

This paper describes three MATLAB-ROS-based simulation projects developed for an undergraduate robotics course. The Robot Operating System (ROS) is an open-source framework that helps researchers and developers build and reuse code between robotics applications. Adoption of ROS in the undergraduate curricula is still rare due to its demanding requirements of C++/Python/Java programming skills and familiarity with Linux. Recently, MathWorks released its ROS Toolbox, making it easier to interact with simulators like the Gazebo and ROS-supported physical robots. The MATLAB-ROS-Gazebo simulation platform allows students to utilize other MATLAB Toolboxes, such as Image Processing, Computer Vision, Visualization, and Navigation Toolboxes, for fast …


A Study On The Design And Production Of A Desktop Vaccuum Cleaner, Aaryan Manoj Nair, Emanuel Pichardo, Isaiah Ortiz, Naeem Kotadia Jun 2023

A Study On The Design And Production Of A Desktop Vaccuum Cleaner, Aaryan Manoj Nair, Emanuel Pichardo, Isaiah Ortiz, Naeem Kotadia

Publications and Research

The goal of this project was to design a desk-top vacuum cleaner that is compact, portable, and effective in cleaning desktops and tabletops. Two concepts were proposed and compared using Quality Function Deployment (QFD) and various metrics, including in-use purposes and market, technical feasibility, ease of use, durability, and cost. The two concepts were a lifting design with hydraulics and a differently sized offset wheel design. After thorough analysis, it was determined that the lifting design with hydraulics was the better concept due to its adjustability and ability to reach different heights and angles on tabletops. The proposed product title …


Multichannel Modulation Of Depolarizing And Repolarizing Ion Currents Increases The Positive Rate-Dependent Action Potential Prolongation, Candido Cabo May 2023

Multichannel Modulation Of Depolarizing And Repolarizing Ion Currents Increases The Positive Rate-Dependent Action Potential Prolongation, Candido Cabo

Publications and Research

Prolongation of the action potential duration (APD) could prevent reentrant arrhythmias if prolongation occurs at the fast excitation rates of tachycardia with minimal prolongation at slow excitation rates (i.e., if prolongation is positive rate-dependent). APD prolongation by current anti-arrhythmic agents is either reverse (larger APD prolongation at slow rates than at fast rates) or neutral (similar APD prolongation at slow and fast rates), which may not result in an effective anti-arrhythmic action. In this report we show that, in computer models of the human ventricular action potential, the combined modulation of both depolarizing and repolarizing ion currents results in a …


Devlopment Of A Practical Method To Quantify Infiltration Rate Through Building Entrance, Eric Reed, Ferasuddin Siddiqui, Louidelson Deguerre, Steve. Boodram May 2023

Devlopment Of A Practical Method To Quantify Infiltration Rate Through Building Entrance, Eric Reed, Ferasuddin Siddiqui, Louidelson Deguerre, Steve. Boodram

Publications and Research

Infiltration through entrance doors, vestibules, cracks and other areas have a large impact in building energy consumption. It also has a significant impact on indoor air quality. There are only a few studies about air infiltration and air tightness in the literature. The purpose of this study is to develop practical methods to measure air infiltration rates through entrance doors. We have read research articles and identify several methods in the literature. Further investigation is required to help more accurately find infraction rate, crack size and location of cracks to help reduce air infiltration, energy costs, maintain comfortable indoor conditions …


Types Of Cyber Attacks And Incident Responses, Kaung Myat Thu May 2023

Types Of Cyber Attacks And Incident Responses, Kaung Myat Thu

Publications and Research

Cyber-attacks are increasingly prevalent in today's digital age, and their impact can be severe for individuals, organizations, and governments. To effectively protect against these threats, it is essential to understand the different types of attacks and have an incident response plan in place to minimize damage and restore normal operations quickly.

This research aims to contribute to the field by addressing the following questions: What are the main types of cyber-attacks, and how can organizations effectively respond to these incidents? How can the incident response process be improved through post-incident activities?

The study examines various cyber-attack types, including malware, phishing, …


Exploring Methods For Recycling Filament Waste In 3d Printing, Max Rios Carballo May 2023

Exploring Methods For Recycling Filament Waste In 3d Printing, Max Rios Carballo

Publications and Research

The goal of the current study is to investigate cutting-edge techniques for recycling filament waste from 3D printing procedures. Appropriate waste management techniques are required to reduce this trash's harmful environmental consequences. The goal of the project is to look at new methods for recycling filament waste in order to minimize disposal and encourage reuse. To acquire data from pertinent papers and research, a thorough literature review methodology was used. The findings show that this issue may be resolved utilizing a variety of recycling techniques, including shredding, melting, and re-extrusion. The type of filament waste and the intended goal will …


Soft X-Ray And Susceptibility Based Magnetic Resonance Imaging To Map Iron Distribution In Apples: Initial Results To Model Iron Storage In Water-Deficient Or Dehydrated Biological Tissue, Subhendra Sarkar, Eric Lobel, Evans Lespinasse, Zoya Vinokur, Analia Basilicata, Sonia Orellana, Maria Orellana, Aaliyah Salmon, Joanna Syska, Aravis Mcbroom, Jian Wang, Anam Riaz, Jody-Ann Douglas Jan 2023

Soft X-Ray And Susceptibility Based Magnetic Resonance Imaging To Map Iron Distribution In Apples: Initial Results To Model Iron Storage In Water-Deficient Or Dehydrated Biological Tissue, Subhendra Sarkar, Eric Lobel, Evans Lespinasse, Zoya Vinokur, Analia Basilicata, Sonia Orellana, Maria Orellana, Aaliyah Salmon, Joanna Syska, Aravis Mcbroom, Jian Wang, Anam Riaz, Jody-Ann Douglas

Publications and Research

Radiology departments have contributed significantly to greenhouse gases including release of toxic imaging contrast media to environment. We feel Radiology also has several spectroscopy and imaging tools that may apply to monitor and support cleaner environmental goals. The current manuscript is one of the firsts to prompt Radiology to move in that direction by non-invasive imaging of bio metals that are less abundant in biological tissues but play key roles as co-factors in tissue structure and function. Conventional analytical tools are mostly invasive and cannot characterize the native oxidation states of bio metals. We chose carbohydrate matrix of metal-rich fruits …


Design Aspects Of Deep Water Distribution Shafts, Navid Allahverdi, V. Nasr Jan 2023

Design Aspects Of Deep Water Distribution Shafts, Navid Allahverdi, V. Nasr

Publications and Research

This paper covers aspects of planning and designing of deep shafts with reference to two water distribution shafts under construction in New York City. The new shafts will be sunk into soil and rock to a depth to connect to existing Queens-Brooklyn tunnel section of City Tunnel No. 3 (CT3). The inside diameter of the upper parts of both shafts is 14.9 meter. Artificial ground freezing is specified as preferred method of excavation support for the entire stretch in soil. Excavation in competent rock will be performed using drill and blast technique preceded by a pre-excavation grouting program. Membrane waterproofing …


Design, Concept, And Visualization Of Urban Multi-Level Growing Table Systems In Hyper Urban Areas, Aaryan Manoj Nair, Shaheed Mohammed, Omar Rahama Dec 2022

Design, Concept, And Visualization Of Urban Multi-Level Growing Table Systems In Hyper Urban Areas, Aaryan Manoj Nair, Shaheed Mohammed, Omar Rahama

Publications and Research

As of a 2019 study conducted by the National Urban Gardening Program (National Urban Gardening Program), urban farming accounts for approximately 19% of the total national farming output and is expected to triple to almost 45% by 2025. There is intensive research being conducted on aspects of reduced recidivism, communal health benefits, natural carbon capture systems, improved urban ecology and the necessity for reducing the carbon footprint of food, (informally dubbed “food miles”) there is little substantive research on optimisation, and maximation of crop productivity in hyper-urban areas.

The purpose of this report is to understand the functionalities of urban …


Additive Manufacturing Process Development Of Geopolymer Based Habitable Construction On Space, Husnain Khan, John Anthony, Maria Hashmi, Charudatta Mhasde Dec 2022

Additive Manufacturing Process Development Of Geopolymer Based Habitable Construction On Space, Husnain Khan, John Anthony, Maria Hashmi, Charudatta Mhasde

Publications and Research

Extraterrestrial travel and housing are topics that have come up in recent times. There is a possibility of living on the moon. Now geopolymers are solid ceramic-like materials at near ambient temperatures. In order to do that while keeping costs at a minimum, we are researching and developing a geopolymer using lunar dust to 3D print houses on the moon. Due to the fact we are using lunar dust, the number of materials that need to be shipped out gets cut dramatically. We are studying the composition of both lunar mares and lunar highlands in order to fully understand what …


Use Of Ai And Machine Learning For Engineering Applications, Max Rios Carballo Dec 2022

Use Of Ai And Machine Learning For Engineering Applications, Max Rios Carballo

Publications and Research

In this paper, we examine how artificial intelligence (AI) and computer-based intelligence (CBI) may be used to address design challenges. We examine artificial intelligence (AI) and machine learning (ML) as they relate to developing applications from the inside out, highlighting the most challenging issues as well as intriguing research areas for further consideration.


Arrayed Waveguide Lens For Beam Steering, Mostafa Honari-Latifpour, Ali Binaie, Mohammad Amin Eftekhar, Nicholas Madamopoulos, Mohammad-Ali Miri Aug 2022

Arrayed Waveguide Lens For Beam Steering, Mostafa Honari-Latifpour, Ali Binaie, Mohammad Amin Eftekhar, Nicholas Madamopoulos, Mohammad-Ali Miri

Publications and Research

Integrated planar lenses are critical components for analog optical information processing that enable a wide range of applications including beam steering. Conventional planar lenses require gradient index control which makes their on-chip realization challenging. Here, we introduce a new approach for beam steering by designing an array of coupled waveguides with segmented tails that allow for simultaneously achieving planar lensing and off-chip radiation. The proposed arrayed waveguide lens is built on engineering the evanescent coupling between adjacent channels to realize a photonic lattice with an equi-distant ladder of propagation constants that emulates the continuous parabolic index profile. Through coupled-mode analysis …


Finite-Difference Analysis Of Stresses Of A Non-Uniform Functionally Graded Material Circular Disk Rotating In The Magneto-Thermal Environment: An Equal Mass Study, Pranta Rahman Sarkar, Akm S. Rahman Jun 2022

Finite-Difference Analysis Of Stresses Of A Non-Uniform Functionally Graded Material Circular Disk Rotating In The Magneto-Thermal Environment: An Equal Mass Study, Pranta Rahman Sarkar, Akm S. Rahman

Publications and Research

The stress field of a functionally graded material rotating disk is studied for different cases of non-uniform thickness variation in the magneto-thermal environment. Three different cases of thickness variation are considered by assuming the variation of non-uniform thickness profiles to be linear, rational, and exponential functions of radius. The mass of the functionally graded material disk is considered equal in all cases of uniform/non-uniform thickness variation. The finite-difference method is used to obtain the numerical results for an Al/Al2O3 functionally graded material disk of fixed-free boundary conditions. The resultant thermo-elastic analysis has shown that the decrease in …


Positive Rate-Dependent Action Potential Prolongation By Modulating Potassium Ion Channels, Candido Cabo Jun 2022

Positive Rate-Dependent Action Potential Prolongation By Modulating Potassium Ion Channels, Candido Cabo

Publications and Research

Pharmacological agents that prolong action potential duration (APD) to a larger extent at slow rates than at the fast excitation rates typical of ventricular tachycardia exhibit reverse rate dependence. Reverse rate dependence has been linked to the lack of efficacy of class III agents at preventing arrhythmias because the doses required to have an anti-arrhythmic effect at fast rates may have pro-arrhythmic effects at slow rates due to an excessive APD prolongation. In this report we show that, in computer models of the ventricular action potential, APD prolongation by accelerating phase 2 repolarization (by increasing IKs) and decelerating …


Spotlight Report #6: Proffering Machine-Readable Personal Privacy Research Agreements: Pilot Project Findings For Ieee P7012 Wg, Noreen Y. Whysel, Lisa Levasseur Jun 2022

Spotlight Report #6: Proffering Machine-Readable Personal Privacy Research Agreements: Pilot Project Findings For Ieee P7012 Wg, Noreen Y. Whysel, Lisa Levasseur

Publications and Research

What if people had the ability to assert their own legally binding permissions for data collection, use, sharing, and retention by the technologies they use? The IEEE P7012 has been working on an interoperability specification for machine-readable personal privacy terms to support this ability since 2018. The premise behind the work of IEEE P7012 is that people need technology that works on their behalf—i.e. software agents that assert the individual’s permissions and preferences in a machine-readable format.

Thanks to a grant from the IEEE Technical Activities Board Committee on Standards (TAB CoS), we were able to explore the attitudes of …


Recent Advances In Bone Research 2022 Edition, Jean-Philippe Berteau, Laurent Pujo-Menjouet May 2022

Recent Advances In Bone Research 2022 Edition, Jean-Philippe Berteau, Laurent Pujo-Menjouet

Publications and Research

More and more scientific and engineering applications in bone research make pivotal advances in treating patients with orthopedics issues. Hence, bone research in the 21st century combines, inter alia, biology, chemistry, mathematics, and mechanics with complementary characteristics that help a holistic approach to bone-related pathologies. Nowadays, it is hard to connect new evidence when jargoning and money remain two significant obstacles to sharing knowledge. “Recent Advances In Bone Research” is a free book – no money involved at any stage - that combines the most recent efforts in bone research from several experts with different backgrounds, every expert seeks to …


The Energy Challenge: Moving From Fossil Fuels To Biofuels, Hydrogen, And Green Energy Sources, Aneeza Hussain, Afrina S. Nishat May 2022

The Energy Challenge: Moving From Fossil Fuels To Biofuels, Hydrogen, And Green Energy Sources, Aneeza Hussain, Afrina S. Nishat

Publications and Research

The aim of this literature research is to evaluate and identify alternative sources of energy instead of fossil fuels. Fossil fuels like natural gas, oil, and coal are known as nonrenewable resources because they are finite resources that cannot be readily replenished at the same pace as their consumption. The alternatives that will be searched for in this literature review are specifically, biofuels, hydrogen, and green energy sources which are all known as renewable. The review will then focus on hydrogen as true potential replacement of fossil fuels. In some countries, alternative renewable sources include geothermal energy, nuclear energy, solar …


Exploring Solidworks Simulation And Structural Analysis Tools To Predict Real-World Physical Behaviors, Itay Rubin May 2022

Exploring Solidworks Simulation And Structural Analysis Tools To Predict Real-World Physical Behaviors, Itay Rubin

Publications and Research

Computer Aided Design (CAD) Software can optimize the product design process prior to manufacturing. This project examines engineering solutions using CAD software called SolidWorks. It simulates how the product will behave under a variety of engineering constraints. These simulations allow designers to optimize performance, cost, and speed efficiencies. The project uses simulations and finite element analysis to replicate real world behavior. It presents high-level capabilities in the design process, exposing new engineers to simulation tools that are available and relevant in mechanical engineering design. This project required independent research to obtain an advanced understanding of the software interface and capabilities.


Designing Respectful Tech: What Is Your Relationship With Technology?, Noreen Y. Whysel Feb 2022

Designing Respectful Tech: What Is Your Relationship With Technology?, Noreen Y. Whysel

Publications and Research

According to research at the Me2B Alliance, people feel they have a relationship with technology. It’s emotional. It’s embodied. And it’s very personal. We are studying digital relationships to answer questions like “Do people have a relationship with technology?” “What does that relationship feel like?” And “Do people understand the commitments that they are making when they explore, enter into and dissolve these relationships?” There are parallels between messy human relationships and the kinds of relationships that people develop with technology. As with human relationships, we move through states of discovery, commitment and breakup with digital applications as well. Technology …


Transcranial Direct Current Stimulation On Parkinson’S Disease: Systematic Review And Meta-Analysis, Paloma Cristina Alves De Oliveira, Thiago Anderson Brito De Araújo, Daniel Gomes Da Silva Machado, Abner Cardoso Rodrigues, Marom Bikson, Suellen Marinho Andrade, Alexandre Hideki Okano, Hougelle Simplicio, Rodrigo Pegado, Edgard Morya Jan 2022

Transcranial Direct Current Stimulation On Parkinson’S Disease: Systematic Review And Meta-Analysis, Paloma Cristina Alves De Oliveira, Thiago Anderson Brito De Araújo, Daniel Gomes Da Silva Machado, Abner Cardoso Rodrigues, Marom Bikson, Suellen Marinho Andrade, Alexandre Hideki Okano, Hougelle Simplicio, Rodrigo Pegado, Edgard Morya

Publications and Research

Background: Clinical impact of transcranial direct current stimulation (tDCS) alone for Parkinson’s disease (PD) is still a challenge. Thus, there is a need to synthesize available results, analyze methodologically and statistically, and provide evidence to guide tDCS in PD.

Objective: Investigate isolated tDCS effect in different brain areas and number of stimulated targets on PD motor symptoms.

Methods: A systematic review was carried out up to February 2021, in databases: Cochrane Library, EMBASE, PubMed/MEDLINE, Scopus, and Web of science. Full text articles evaluating effect of active tDCS (anodic or cathodic) vs. sham or control on motor symptoms of PD were …


Glycocalyx Mechanotransduction Mechanisms Are Involved In Renal Cancer Metastasis, Heriberto Moran, Limary M. Cancel, Peigen Huang, Sylvie Roberge, Tuoye Xu, John M. Tarbell, Lance L. Munn Jan 2022

Glycocalyx Mechanotransduction Mechanisms Are Involved In Renal Cancer Metastasis, Heriberto Moran, Limary M. Cancel, Peigen Huang, Sylvie Roberge, Tuoye Xu, John M. Tarbell, Lance L. Munn

Publications and Research

Mammalian cells, including cancer cells, are covered by a surface layer containing cell bound proteoglycans, glycoproteins, associated glycosaminoglycans and bound proteins that is commonly referred to as the glycocalyx. Solid tumors also have a dynamic fluid microenvironment with elevated interstitial flow. In the present work we further investigate the hypothesis that interstitial flow is sensed by the tumor glycocalyx leading to activation of cell motility and metastasis. Using a highly metastatic renal carcinoma cell line (SN12L1) and its low metastatic counterpart (SN12C) we demonstrate in vitro that the small molecule Suberoylanilide Hydroxamic Acid (SAHA) inhibits the heparan sulfate synthesis enzyme …


Toward A Multimodal Computer-Aided Diagnostic Tool For Alzheimer’S Disease Conversion, Danilo Pena, Jessika Suescun, Mya Schiess, Timothy M. Ellmore, Luca Giancardo, Alzheimer’S Disease Neuroimaging Initiative Jan 2022

Toward A Multimodal Computer-Aided Diagnostic Tool For Alzheimer’S Disease Conversion, Danilo Pena, Jessika Suescun, Mya Schiess, Timothy M. Ellmore, Luca Giancardo, Alzheimer’S Disease Neuroimaging Initiative

Publications and Research

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder. It is one of the leading sources of morbidity and mortality in the aging population AD cardinal symptoms include memory and executive function impairment that profoundly alters a patient’s ability to perform activities of daily living. People with mild cognitive impairment (MCI) exhibit many of the early clinical symptoms of patients with AD and have a high chance of converting to AD in their lifetime. Diagnostic criteria rely on clinical assessment and brain magnetic resonance imaging (MRI). Many groups are working to help automate this process to improve the clinical workflow. Current …


Biomedical Applications Of Lanthanide Nanomaterials, For Imaging, Sensing And Therapy, Qize Zhang, Stephen O'Brien, Jan Grimm Jan 2022

Biomedical Applications Of Lanthanide Nanomaterials, For Imaging, Sensing And Therapy, Qize Zhang, Stephen O'Brien, Jan Grimm

Publications and Research

The application of nanomaterials made of rare earth elements within biomedical sciences continues to make significant progress. The rare earth elements, also called the lanthanides, play an essential role in modern life through materials and electronics. As we learn more about their utility, function, and underlying physics, we can contemplate extending their applications to biomedicine. This particularly applies to diagnosis and radiation therapy due to their relatively unique features, such as an ultra-wide Stokes shift in the luminescence, variable magnetism and potentially tunable properties, due to the library of lanthanides available and their multivalent oxidation state chemistry. The ability to …