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Biomarkers For Brain Disorders Electrochemically Detected By Broderick Probe Microelectrodes/Biosensors, Waqas Saleem, Patricia A. Broderick
Biomarkers For Brain Disorders Electrochemically Detected By Broderick Probe Microelectrodes/Biosensors, Waqas Saleem, Patricia A. Broderick
Publications and Research
Here, we present results from two independent studies carried out using Neuromolecular Imaging (NMI) with miniature BRODERICK PROBE® biosensors. In the first study, we imaged neurotransmitters and neurochemicals in human epilepsy patients intraoperatively during early and late neurodegeneration. In the second study, we imaged neurotransmitters and neurochemicals in an experimental murine model using animals with and without neurodegeneration caused by Parkinson’s disease (PD). We compared our results derived from animals with lesioned group (PD) with non-lesioned group (non-PD), using the same in vivo NMI paradigm. NMI biotechnology enabled neurotransmitters, neuropeptides and neurochemical imaging of dopamine (DA), serotonin (5-HT), homovanillic acid …
Computational Model Of Neuron-Astrocyte Interputational Model Of Neuron-Astrocyte Interactions During Focal Seizure Generationactions During Focal Seizure Generation, Davide Reato, Mario Cammarota, Lucas C. Parra, Giorgio Carmignoto
Computational Model Of Neuron-Astrocyte Interputational Model Of Neuron-Astrocyte Interactions During Focal Seizure Generationactions During Focal Seizure Generation, Davide Reato, Mario Cammarota, Lucas C. Parra, Giorgio Carmignoto
Publications and Research
Empirical research in the last decade revealed that astrocytes can respond to neurotransmitters with Ca2+ elevations and generate feedback signals to neurons which modulate synaptic transmission and neuronal excitability. This discovery changed our basic understanding of brain function and provided new perspectives for how astrocytes can participate not only to information processing, but also to the genesis of brain disorders, such as epilepsy. Epilepsy is a neurological disorder characterized by recurrent seizures that can arise focally at restricted areas and propagate throughout the brain. Studies in brain slice models suggest that astrocytes contribute to epileptiform activity by increasing neuronal excitability …