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Full-Text Articles in Engineering
The Sub-Chronic Vascular Response To Water-Borne Embolic Coacervates., Joshua P. Jones, Monika Sima, Russell J. Stewart
The Sub-Chronic Vascular Response To Water-Borne Embolic Coacervates., Joshua P. Jones, Monika Sima, Russell J. Stewart
Biomedical Engineering Western Regional Conference
Water-borne coacervates that solidify in response to decreasing ionic strength have been developed as an agent for small vessel transcatheter embolization. Here, the sub-chronic vascular response to these agents will be presented. Embolic coacervates demonstrated a benign foreign body response, which supported tissue ingrowth and stabilized vessel occlusion out to 28 days. As with other liquid embolics, occlusion is dependent upon mechanical obstruction of the vessel and native thrombus. Over time, the thrombus becomes more organized by fibroblasts. Continuation of the processes seen at 28 days will likely result in fibrous encapsulation of the embolic coacervate, further stabilizing the occlusion.
Differentiation And Containment Of Derived Pancreatic Beta Cells, Caden Duffy, Alonzo Cook Ph.D.
Differentiation And Containment Of Derived Pancreatic Beta Cells, Caden Duffy, Alonzo Cook Ph.D.
Biomedical Engineering Western Regional Conference
Currently, the only permanent cure for Type 1 Diabetes is a pancreatic or islet transplant. With the shortage of donors, we are progressing research towards alternative therapies by differentiating induced pluripotent stem cells into derived pancreatic β-cells that can be transplanted and used as treatment for Type 1 Diabetes. We are investigating methods to increase the yield of fully derived, insulin producing pancreatic β-cells and are additionally researching the use of hydrophilized expanded polytetrafluoroethylene for use in cell containment devices. These devices could offer a future alternative for islet transplantation in human patients.
Super-Hydrophobic And Anti-Microbial Surfaces Via Carbon Infiltrated-Carbon Nanotubes, Christian Dalon Esplin, Anton Bowden, Brian Jensen
Super-Hydrophobic And Anti-Microbial Surfaces Via Carbon Infiltrated-Carbon Nanotubes, Christian Dalon Esplin, Anton Bowden, Brian Jensen
Biomedical Engineering Western Regional Conference
No abstract provided.
Structural Mrsa Resistance Through Carbon-Infiltrated Carbon Nanotube Coating Of External Fixator Pins, Jaclyn Larsen, Stephanie Morco, Brian Jensen, Anton Bowden
Structural Mrsa Resistance Through Carbon-Infiltrated Carbon Nanotube Coating Of External Fixator Pins, Jaclyn Larsen, Stephanie Morco, Brian Jensen, Anton Bowden
Biomedical Engineering Western Regional Conference
No abstract provided.
Resorption Rate Of Bioresorbable Materials For Possible Use In Self-Expanding Stents, Jared R. Park, Jason Porter, Anton Bowden
Resorption Rate Of Bioresorbable Materials For Possible Use In Self-Expanding Stents, Jared R. Park, Jason Porter, Anton Bowden
Biomedical Engineering Western Regional Conference
This study investigates the mechanical behavior of various polymers after a period of degradation from exposure to a Saline Solution. The study found that PLA and PDLLA do not have significant degradation over a period of 2 months, while PLA has a sharp decrease in strength after 7 days.
Effect Of Multiple Confined Compression/Stress Relaxation Cycles On Cross-Linked Alginate Pore Size., Sindhu Kolar Venkat, Erik L. Risa, Bergren Antell, Maryam Mobed-Miremadi
Effect Of Multiple Confined Compression/Stress Relaxation Cycles On Cross-Linked Alginate Pore Size., Sindhu Kolar Venkat, Erik L. Risa, Bergren Antell, Maryam Mobed-Miremadi
Biomedical Engineering Western Regional Conference
No abstract provided.
Towards A Bioselective Surface For Treatment Of Sepsis In A Hemoperfusion Device, Karl F. Schilke, Ramya Raman, Bonan Yu, Erik Hahn, Jonathan Su
Towards A Bioselective Surface For Treatment Of Sepsis In A Hemoperfusion Device, Karl F. Schilke, Ramya Raman, Bonan Yu, Erik Hahn, Jonathan Su
Biomedical Engineering Western Regional Conference
Sepsis is a dysregulated immune response to circulating bacteria/endotoxin. Hemoperfusion is a promising treatment, but is not universally effective and can unacceptable blood damage. We are developing protein-repellent hydrogel nanofilms that can be grown on a variety of surfaces, and functionalized with “click-ready” pathogen-binding proteins expressed by Genetic Code Expansion (GCE). The extremely rapid, bioorthogonal “click” immobilization chemistry eliminates prior purification, maximizes surface loading, and guarantees spatial orientation of the immobilized proteins. We have demonstrated pathogen binding and blood protein repulsion by these layers, suggesting that they may be part of effective treatments for sepsis and other applications.
Molecular Modeling Of Antibody-Antigen Binding Near Solid Surfaces, Derek Bush, Thomas Knotts
Molecular Modeling Of Antibody-Antigen Binding Near Solid Surfaces, Derek Bush, Thomas Knotts
Biomedical Engineering Western Regional Conference
Antibody microarrays are biosensors that have the potential to revolutionize molecular detection in medicine, scientific research, and national defense. However, current microarrays are not widely used due to problems including poor reproducibility and signal quality, unbalanced antibody performance, and cross-reactivity. Prior work in the area focused mainly on the stability of the antibody alone and not its affinity for its antigen. This presentation shows results of using molecular simulation to determine how different types of surfaces affect antigen binding to surface-tethered antibodies. The results offer an unprecedented, molecular-level view into these protein-protein-surface interactions and how to drive binding to occur.