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Articles 1 - 30 of 179
Full-Text Articles in Engineering
Supporting Text And Data Analysis Across Campus From The Academic Library, Amy Kirchhoff, Hejin Shin Phd
Supporting Text And Data Analysis Across Campus From The Academic Library, Amy Kirchhoff, Hejin Shin Phd
Digital Initiatives Symposium
The ability to comprehend and communicate with text-based data is essential to future success in academics and employment, as evidenced in a recent survey from Bloomberg Research Services which shows that nearly 97% of survey respondents now use data analytics in their companies and 58% consider data and text mining a business analytics tool (https://www.sas.com/content/dam/SAS/bp_de/doc/studie/ba-st-the-current-state-of-business-analytics-2317022.pdf). This has fueled a substantial growth in text analysis research (involving the use of technology to analyze un- and semi-structured text data for valuable insights, trends, and patterns) across disciplines and a corresponding demand on academic libraries to support text analysis pedagogy and text analysis …
Revolutionizing Feature Selection: A Breakthrough Approach For Enhanced Accuracy And Reduced Dimensions, With Implications For Early Medical Diagnostics, Shabia Shabir Khan, Majid Shafi Kawoosa, Bonny Bannerjee, Subhash C. Chauhan, Sheema Khan
Revolutionizing Feature Selection: A Breakthrough Approach For Enhanced Accuracy And Reduced Dimensions, With Implications For Early Medical Diagnostics, Shabia Shabir Khan, Majid Shafi Kawoosa, Bonny Bannerjee, Subhash C. Chauhan, Sheema Khan
Research Symposium
Background: The system's performance may be impacted by the high-dimensional feature dataset, attributed to redundant, non-informative, or irrelevant features, commonly referred to as noise. To mitigate inefficiency and suboptimal performance, our goal is to identify the optimal and minimal set of features capable of representing the entire dataset. Consequently, the Feature Selector (Fs) serves as an operator, transforming an m-dimensional feature set into an n-dimensional feature set. This process aims to generate a filtered dataset with reduced dimensions, enhancing the algorithm's efficiency.
Methods: This paper introduces an innovative feature selection approach utilizing a genetic algorithm with an ensemble crossover operation …
Oral Administration Of Ph-Responsive Polymeric Nanoparticles Based On Zein And Their Therapeutic Potential On Cancer., Bruno Alejandro Valades-Aguilar, José Raúl Rangel-López, Jennifer Citlally Leos-Rivera, Moisés Armides Franco-Molina, María Cristina Rodríguez-Padilla, Diana Ginette Zárate-Triviño
Oral Administration Of Ph-Responsive Polymeric Nanoparticles Based On Zein And Their Therapeutic Potential On Cancer., Bruno Alejandro Valades-Aguilar, José Raúl Rangel-López, Jennifer Citlally Leos-Rivera, Moisés Armides Franco-Molina, María Cristina Rodríguez-Padilla, Diana Ginette Zárate-Triviño
Research Symposium
Background: Zein is a water-insoluble protein extracted from the endosperm of corn seeds, this polymer is an attractive matrix to encapsulate hydrophilic compounds because of its high proportion of hydrophobic amino acids, making it a potential smart delivery material for several treatments in the biopharmaceutical industry. nanoparticles have been used as drug delivery systems for the improvement of oral bioavailability; however, the strategies of nanoparticle obtention need the addition of stabilizers. in this study, a modified method to obtain zein nanoparticles was developed.
Methods: Zein nanoparticles (ZNps) were made by a thermal treatment and precipitated into ovalbumin at a ratio …
La1-Xsrxcoo3 Perovskite Nanomaterial: Synthesis, Characterization, And Its Biomedical Application, Adhira Tippur, Anyet Shohag, Luke Franco, Ahmed Touhami, Swati Mohan, Mohammed Uddin
La1-Xsrxcoo3 Perovskite Nanomaterial: Synthesis, Characterization, And Its Biomedical Application, Adhira Tippur, Anyet Shohag, Luke Franco, Ahmed Touhami, Swati Mohan, Mohammed Uddin
Research Symposium
Early cancer detection is paramount for effective treatment and potential cures. This research explores the application of perovskite materials, specifically Sr2+-doped Lanthanum Cobaltite (La1-xSrxCoO3) nanomaterials, in cancer detection, with a focus on rats as an experimental model. The ferroelectric nature of these materials, synthesized through a combination of sol-gel and molten-salt processes, was examined at varying Sr2+ doping levels (1-20 wt%). Rigorous characterization, employing X-ray diffraction and scanning electron microscopy, confirmed the uniform morphology of nano cubes, laying the foundation for subsequent investigations. The magnetic properties of the perovskite nanoparticles were probed, suggesting their potential as a diagnostic tool for …
Emotion Recognition As A Novel Indicator For Assessing Brain Health: A Machine Learning Approach, Nayarah Shabir, Parveen Lehana
Emotion Recognition As A Novel Indicator For Assessing Brain Health: A Machine Learning Approach, Nayarah Shabir, Parveen Lehana
Research Symposium
Background: Emotion is being referred to as a person’s mental state, since it relates to their ideas, feelings, and actions. There is a lot of evidence that health affects the emotion. Therefore, the nature of emotions ought to reveal the health of a person. The emotions are represented by facial expressions controlled by muscular motor actions. Brain health may affect the working of the muscles leading to the emotional changes extracted from the facial images.
Methods: A dataset of facial images annotated with matching emotion labels is the first step in using convolutional neural networks (CNNs) for facial …
Modified Zero-Gravity Chair In The Management Of Pain And Anxiety With Emphasis On Pre And Post Anesthesia For Surgical Procedures, Alexander Tisdale, Kinsley Batson, Zachary Jamous, Isabella Termini, Kyle Mooday, Matt Cohn, Jackson Justice
Modified Zero-Gravity Chair In The Management Of Pain And Anxiety With Emphasis On Pre And Post Anesthesia For Surgical Procedures, Alexander Tisdale, Kinsley Batson, Zachary Jamous, Isabella Termini, Kyle Mooday, Matt Cohn, Jackson Justice
Annual Research Symposium
The purpose of this research is the integration of a zero-gravity chair with planar vibration as a non-pharmaceutical approach to preoperative anxiety and postoperative pain management. The treatment plan involves preoperative familiarization with the chair's vibrational patterns and postoperative use for pain relief. Integration of this approach holds promise in reshaping postoperative care paradigms, advocating for personalized, holistic interventions to enhance patient well-being and mitigate opioid-related risks.
Understanding Collegiate Aviation Pilot Mental Performance Studies And Future Research Opportunities, Debra Henneberry, Stephanie Brown, Flavio Coimbra, Julius Keller
Understanding Collegiate Aviation Pilot Mental Performance Studies And Future Research Opportunities, Debra Henneberry, Stephanie Brown, Flavio Coimbra, Julius Keller
National Training Aircraft Symposium (NTAS)
According to the Federal Aviation Administration (2022), fatigue is defined as “a condition characterized by increased discomfort with lessened capacity for work, reduced efficiency of accomplishment, loss of power or capacity to respond to stimulation, and is usually accompanied by a feeling of weariness and tiredness” (p. 2). Further outcomes of fatigue include tiredness, weakness, lack of energy, lethargy, depression, and lack of motivation (ICAO, 2016). Stress can release cortisol which can in turn cause sleep issues leading to fatigue (Harvard, 2021). In one study Mendonca, Keller, and Albelo (2023) found 69% (n = 192) percent of collegiate aviation pilots …
Multimode Point Spectroscopy For Food Authentication, Sayed Asaduzzaman, Nicholas Mackinnon, Hossein Kashani Zadeh
Multimode Point Spectroscopy For Food Authentication, Sayed Asaduzzaman, Nicholas Mackinnon, Hossein Kashani Zadeh
SDSU Data Science Symposium
Enhancing food quality measurement is a necessity to guarantee food safety and adherence to health regulations. Current methods involve lab testing which are time-consuming, costly, destructive and require skilled workers. Spectroscopy has the potential to overcome these challenges. This study employs a multi-mode point spectroscopy method to distinguish food products according to their spectral characteristics,. The system records fluorescence, excited at 365 and 405 nm, visible-near infrared (Vis-NIR) and short-wave infrared (SWIR) spectra. The three main subjects of the study are olive oil, milk, and honey. Samples were kept in a transparent cell culture pot, and Gray and White Spectralon …
Enhancing The Tribological Performance Of Prosthetic Implants: An Investigation Of Cnc Surface Micro-Texturing On Uhmwpe, Javier Ortega, J. Perez, N. Perez
Enhancing The Tribological Performance Of Prosthetic Implants: An Investigation Of Cnc Surface Micro-Texturing On Uhmwpe, Javier Ortega, J. Perez, N. Perez
Research Symposium
Background: Annually, there are over a million joint replacement procedures and more than 250,000 revision surgeries in the United States. The typical lifespan of a joint replacement ranges from 7 to 15 years, often curtailed by complications such as excessive implant wear leading to infections and joint dislocations. Given that most joint replacement recipients are between the ages of 50 and 70, the later part of their lives is often marred by repeated surgeries and discomfort. Presently, the predominant material used in joint replacements is medical-grade Ultra-High Molecular Weight Polyethylene (UHMWPE) with smooth surfaces. While these smooth surfaces are believed …
Large Language Model Use Cases For Instruction, Plus A Primer On Prompt Engineering, Roy Haggerty, Justin Cochran
Large Language Model Use Cases For Instruction, Plus A Primer On Prompt Engineering, Roy Haggerty, Justin Cochran
LSU Health New Orleans Symposium Series on Artificial Intelligence
AMA Credit Designation Statement: The Louisiana State University School of Medicine, New Orleans designates this live activity for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
NCPD Credit Designation Statement: Nursing participants may earn 1.0 NCPD contact hours. Each nursing participant must be present for the entire session for which NCPD contact hours are requested and must complete an evaluation of the session to receive credit.
12th International Conference On Business, Technology And Innovation 2023, University For Business And Technology - Ubt
12th International Conference On Business, Technology And Innovation 2023, University For Business And Technology - Ubt
UBT International Conference
Welcome to IC – UBT 2023
UBT Annual International Conference is the 12th international interdisciplinary peer reviewed conference which publishes works of the scientists as well as practitioners in the area where UBT is active in Education, Research and Development. The UBT aims to implement an integrated strategy to establish itself as an internationally competitive, research-intensive university, committed to the transfer of knowledge and the provision of a world-class education to the most talented students from all background. The main perspective of the conference is to connect the scientists and practitioners from different disciplines in the same place and make …
Engineering Of Functionalized Carbon Nano-Onions Embedded Bsa Nanocomposite Fibers For Stimuli-Responsive Drug Release, Ramiro Manuel Velasco Delgadillo, Narsimha Mamidi
Engineering Of Functionalized Carbon Nano-Onions Embedded Bsa Nanocomposite Fibers For Stimuli-Responsive Drug Release, Ramiro Manuel Velasco Delgadillo, Narsimha Mamidi
Research Symposium
Background: Advanced drug delivery systems (DDSs) have received enormous attention in biomedical applications due to their pharmacodynamic and pharmacokinetic drug properties. For the present study, poly 4-hydroxyphenyl methacrylate (PHPMA)/CNOs (f-CNOs) inserted bovine serum albumin (BSA) nanofibers were prepared for stimuli-responsive release of Doxorubicin (DOX). Temperature and pH would be altered to study the release of DOX in acidic microenvironments.
Methods: PHPMA were coupled with COOH-CNOs via ester coupling via the sonochemical method to produce PHPMA-CNOs (f-CNOs). Then, f-CNOs/DOX embedded BSA nanofibers were prepared at room temperature using Forcespinning. UV spectra of DOX-loaded nanofibers were studied to investigate the …
Biocidal Properties Of Hybrid Nanonanomaterial, Chandrasekaran Karthikeyan, Kokkarachedu Varaprasad
Biocidal Properties Of Hybrid Nanonanomaterial, Chandrasekaran Karthikeyan, Kokkarachedu Varaprasad
Research Symposium
Background: Cancer is one of the essential unpredictable diseases worldwide; simultaneously, complicated issues created are by the human health system. Especially, breast cancer is the most commonly occurring cancer in women and is increasing remarkably in developing countries. It is a leading cause of cancer death in women, and breast cancer incidence rates are growing globally. To diagnose and treat cancer cells, different methods such as Radiation Therapy, Surgery, and Chemotherapy. These methods are high risk, more side effects, and high costs. The advanced healthcare material was developed to overcome this problem, inexpensive tools, and diagnosis of less-toxic drugs with …
A 3d Printed Microneedle System For Transdermal Drug Delivery Of Anticancer Drugs, Md Jasim Uddin, Tanvir Ahmed, Dennis Douroumis
A 3d Printed Microneedle System For Transdermal Drug Delivery Of Anticancer Drugs, Md Jasim Uddin, Tanvir Ahmed, Dennis Douroumis
Research Symposium
Background: Transdermal delivery of drugs is an attractive alternative to the conventional route of administration as oral delivery. The hypodermic injections are painful and less patient compliance. Microneedles (MNs) are micron-sized, minimally invasive needles to deliver a wide range of molecules (e.g., small, DNA, vaccines etc.) to the upper portion of the dermis in a sustained and controlled manner, without causing any pain. The introduction of 3D printing technologies in the fabrication of MN will promote one-step manufacturing tools and scale-up for the delivery devices of anticancer drugs.
Methods: The 3D printed MN (3DMN) arrays were fabricated using Stereolithography (SLA), …
L(D)-Tyrosine-Mediated One-Step Chiral Graphene Production For Chirality-Dependent Sensing, Fnu Pranav, Ali Ashraf, Meena Jaggi, Subhash C. Chauhan, Murali M. Yallapu
L(D)-Tyrosine-Mediated One-Step Chiral Graphene Production For Chirality-Dependent Sensing, Fnu Pranav, Ali Ashraf, Meena Jaggi, Subhash C. Chauhan, Murali M. Yallapu
Research Symposium
Background: Chirality has been the most iconic phenomenon that occurred in nature. The idea of mirror-image asymmetry associated with the biological entity is still unsolved The emergence of 2D layered nanomaterials which have already shown amazing properties and a wide range of applications, especially in the areas of sensing.Amino acids enantiomers have similar physical and chemical properties however their physiological responses get changed based on the enantiomers. For example, L from amino acids helps body in protein formation, and generation of biological signals etc. whereas the D-form may cause toxic effects. We have developed a novel and facile synthesis method …
Noninvasively Monitoring Of Cerebral Blood Flow In Piglet Models Of Graded Hemorrhage And Hypoxic Ischemic Brain Injury Using Diffuse Correlation Spectroscopy And Near-Infrared Spectroscopy, Randolph Sinahon, Danielle Shoshany, Shadi Malaeb, Mert Deniz Polat, Meltem Izzetoglu, Kurtulus Izzetoglu
Noninvasively Monitoring Of Cerebral Blood Flow In Piglet Models Of Graded Hemorrhage And Hypoxic Ischemic Brain Injury Using Diffuse Correlation Spectroscopy And Near-Infrared Spectroscopy, Randolph Sinahon, Danielle Shoshany, Shadi Malaeb, Mert Deniz Polat, Meltem Izzetoglu, Kurtulus Izzetoglu
St. Chris Research Day
No abstract provided.
Cerebral Blood Flow Measured By Diffuse Correlation Spectroscopy For Monitoring Depth Of Anesthesia In Piglets, Mert Deniz Polat, Kurtulus Izzetoglu, Randolph Sinahon, Meltem Izzetoglu, Shadi Malaeb
Cerebral Blood Flow Measured By Diffuse Correlation Spectroscopy For Monitoring Depth Of Anesthesia In Piglets, Mert Deniz Polat, Kurtulus Izzetoglu, Randolph Sinahon, Meltem Izzetoglu, Shadi Malaeb
St. Chris Research Day
No abstract provided.
Modeling Epithelial-Mesenchymal Transition In A 3d Multicellular Model Of Tgf-Β1 Signaling, Kristin Kim, Chris Lemmon
Modeling Epithelial-Mesenchymal Transition In A 3d Multicellular Model Of Tgf-Β1 Signaling, Kristin Kim, Chris Lemmon
Biology and Medicine Through Mathematics Conference
No abstract provided.
Enhancement Of Deep Learning Protein Structure Prediction, Ruoming Shen
Enhancement Of Deep Learning Protein Structure Prediction, Ruoming Shen
Modeling, Simulation and Visualization Student Capstone Conference
Protein modeling is a rapidly expanding field with valuable applications in the pharmaceutical industry. Accurate protein structure prediction facilitates drug design, as extensive knowledge about the atomic structure of a given protein enables scientists to target that protein in the human body. However, protein structure identification in certain types of protein images remains challenging, with medium resolution cryogenic electron microscopy (cryo-EM) protein density maps particularly difficult to analyze. Recent advancements in computational methods, namely deep learning, have improved protein modeling. To maximize its accuracy, a deep learning model requires copious amounts of up-to-date training data.
This project explores DeepSSETracer, a …
A Comparison Of Nonverbal And Paraverbal Behaviors In Simulated And Virtual Patient Encounters, Sarah Powers, Mark W. Scerbo, Matthew Pacailler, Macy Kisiel, Baillie Hirst, Ginger S. Watson, Lauren Hamel, Fred Kron
A Comparison Of Nonverbal And Paraverbal Behaviors In Simulated And Virtual Patient Encounters, Sarah Powers, Mark W. Scerbo, Matthew Pacailler, Macy Kisiel, Baillie Hirst, Ginger S. Watson, Lauren Hamel, Fred Kron
Modeling, Simulation and Visualization Student Capstone Conference
The present study assessed whether trainees display similar nonverbal and paraverbal behaviors when interacting with a simulated (SP) and virtual patient (VP). Sixty second slices of time following four interactions were rated for the presence and frequency of three nonverbal and paraverbal behaviors. Results revealed that students exhibited fewer behaviors in the VP interaction, possibly due to differences social inhibition or fidelity between the two formats.
"Challenging The Known." 16th Annual Research Week: Event Proceedings, University Of The Incarnate Word
"Challenging The Known." 16th Annual Research Week: Event Proceedings, University Of The Incarnate Word
Research Week Archived Proceedings
Presentations of completed and ongoing research activity conducted by graduate students, undergraduate students, and faculty at University of the Incarnate Word. Includes poster, podium, visual arts, interactive demo, and creative and performing arts presentations. Coordinated and presented by the Office of Research and Graduate Studies.
The Effects Of Demographics And Risk Factors On The Morphological Characteristics Of Human Femoropopliteal Arteries, Sayed Ahmadreza Razian, Majid Jadidi, Alexey Kamenskiy
The Effects Of Demographics And Risk Factors On The Morphological Characteristics Of Human Femoropopliteal Arteries, Sayed Ahmadreza Razian, Majid Jadidi, Alexey Kamenskiy
UNO Student Research and Creative Activity Fair
Background: Disease of the lower extremity arteries (Peripheral Arterial Disease, PAD) is associated with high morbidity and mortality. During disease development, the arteries adapt by changing their diameter, wall thickness, and residual deformations, but the effects of demographics and risk factors on this process are not clear.
Methods: Superficial femoral arteries from 736 subjects (505 male, 231 female, 12 to 99 years old, average age 51±17.8 years) and the associated demographic and risk factor variables were used to construct machine learning (ML) regression models that predicted morphological characteristics (diameter, wall thickness, and longitudinal opening angle resulting from the …
Session 12: Active Learning To Minimize The Possible Risk From Future Epidemics, Kc Santosh
Session 12: Active Learning To Minimize The Possible Risk From Future Epidemics, Kc Santosh
SDSU Data Science Symposium
In medical imaging informatics, for any future epidemics (e.g., Covid-19), deep learning (DL) models are of no use as they require a large dataset as they take months and even years to collect enough data (with annotations). In such a context, active learning (or human/expert-in-the-loop) is the must, where a machine can learn from the first day with minimum possible labeled data. In unsupervised learning, we propose to build pre-trained DL models that iteratively learn independently over time, where human/expert intervenes only when it makes mistakes and for only a limited data. In our work, deep features are used to …
2d Respiratory Sound Analysis To Detect Lung Abnormalities, Rafia Sharmin Alice, Kc Santosh
2d Respiratory Sound Analysis To Detect Lung Abnormalities, Rafia Sharmin Alice, Kc Santosh
SDSU Data Science Symposium
Abstract. In this paper, we analyze deep visual features from 2D data representation(s) of the respiratory sound to detect evidence of lung abnormalities. The primary motivation behind this is that visual cues are more important in decision-making than raw data (lung sound). Early detection and prompt treatments are essential for any future possible respiratory disorders, and respiratory sound is proven to be one of the biomarkers. In contrast to state-of-the-art approaches, we aim at understanding/analyzing visual features using our Convolutional Neural Networks (CNN) tailored Deep Learning Models, where we consider all possible 2D data such as Spectrogram, Mel-frequency Cepstral Coefficients …
High Energy Blue Light Induces Oxidative Stress And Retinal Cell Apoptosis, Jessica Malinsky
High Energy Blue Light Induces Oxidative Stress And Retinal Cell Apoptosis, Jessica Malinsky
Capstone Showcase
Blue light (BL) is a high energy, short wavelength spanning 400 to 500 nm. Found in technological and environmental forms, BL has been shown to induce photochemical damage of the retina by reactive oxygen species (ROS) production. Excess ROS leads to oxidative stress, which disrupts retinal mitochondrial structure and function. As mitochondria amply occupy photoreceptors, they also contribute to oxidative stress due to their selectively significant absorption of BL at 400 to 500 nm. ROS generation that induces oxidative stress subsequently promotes retinal mitochondrial apoptosis. BL filtering and preventative mechanisms have been suggested to improve or repair BL-induced retinal damage, …
Analyzing The Past Five Years Of Equinox Week* Programs Focused On Sustainable Development Goals Within A Collection Of Local And Global Initiatives To Support A Proposal For The Publication Of A Comprehensive Book, Abdoulaye Idrissa
Symposium of Student Scholars
Many undergraduate students are not familiar with the research process involved in a book publication proposal. Through this multidisciplinary collaborative research, the faculty intends to minimize this gap by engaging the students in such a process from the early phase of proposal preparation. The student will research and review the past five years of EQUINOX Week* programs focused on Sustainable Development Goals within a collection of local and global initiatives to support a proposal for the EQUINOX proceeding publication.
With an extensive set of qualitative and quantitative data gathered over a span of 5 years. The student will be …
11th International Conference On Business, Technology And Innovation 2022, University For Business And Technology - Ubt
11th International Conference On Business, Technology And Innovation 2022, University For Business And Technology - Ubt
UBT International Conference
Welcome to IC – UBT 2022
UBT Annual International Conference is the 11th international interdisciplinary peer reviewed conference which publishes works of the scientists as well as practitioners in the area where UBT is active in Education, Research and Development. The UBT aims to implement an integrated strategy to establish itself as an internationally competitive, research-intensive university, committed to the transfer of knowledge and the provision of a world-class education to the most talented students from all background. The main perspective of the conference is to connect the scientists and practitioners from different disciplines in the same place and make …
Using Design Science Research To Create A Virtual Environment For Nursing Students, Benjamin Botha, Lizette De Wet
Using Design Science Research To Create A Virtual Environment For Nursing Students, Benjamin Botha, Lizette De Wet
African Conference on Information Systems and Technology
This paper aims to provide insight into the design science research approach followed during a transdisciplinary research study between computer scientists and professional nurses. The researchers used a design science research approach to create a virtual environment where nursing students could practice managing a patient with a foreign object in the right lung. The virtual environment underwent multiple changes as it progressed through the different cycles of design science research. Within these cycles, namely the relevance, design, and rigor cycle, various iterations of each of the cycles took place. Presented in this paper the design science approach followed will be …
Open-Source And 3-D Printed Autoinjector, Anjutha Selvaraj
Open-Source And 3-D Printed Autoinjector, Anjutha Selvaraj
Undergraduate Student Research Internships Conference
Autoinjectors have become popular modern injectable medical devices used as drug delivery systems. Due to its ease, capability and reliability compared to other conventional injectable medical devices, the market and manufacturing demand for autoinjector devices are increasing at a staggering rate. Although autoinjectors can offset healthcare treatment costs through self-administered medication, they are expensive for consumers. This paper describes the design and manufacture of a spring-driven and 3-D printed autoinjector using open-source hardware. By making it an open-source resource for everyone, the barrier of advanced research in design and production can be lifted, thus making it easily manufacturable and cost-effective. …
Producing And Measuring Oscillatory Shear In A Novel Microfluidic Chip, Sanaz Lordfard, Daniel Lorusso, Tamie L. Poepping, Hristo N Nikolov, Kayla Soon, Stephen Sims, Jeffrey Dixon, David Holdsworth
Producing And Measuring Oscillatory Shear In A Novel Microfluidic Chip, Sanaz Lordfard, Daniel Lorusso, Tamie L. Poepping, Hristo N Nikolov, Kayla Soon, Stephen Sims, Jeffrey Dixon, David Holdsworth
Undergraduate Student Research Internships Conference
Purpose: To demonstrate the effectiveness of a novel microfluidic device mimicking oscillatory blood flow, allowing cell biologists to examine how endothelial cells respond to a range of oscillatory shear stress levels.
Methods: The microfluidic chip consists of a circular-shaped reservoir, leading to a rectangular channel that is examined under a microscope. The plunger is connected to a speaker system and oscilloscope, allowing the plunger to apply a range of frequencies (5-60Hz) and voltages (5-10 V, leading to a variety in oscillation amplitudes) to the reservoir region. 1.1 um fluorescent particles diluted in distilled water were used for tracking. Processing was …