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Full-Text Articles in Engineering

"A Comparison Of Variable Selection Methods Using Bootstrap Samples From Environmental Metal Mixture Data", Paul-Yvann Djamen 4785403, Paul-Yvann Djamen Jul 2020

"A Comparison Of Variable Selection Methods Using Bootstrap Samples From Environmental Metal Mixture Data", Paul-Yvann Djamen 4785403, Paul-Yvann Djamen

Mathematics & Statistics ETDs

In this thesis, I studied a newly developed variable selection method SODA, and three customarily used variable selection methods: LASSO, Elastic net, and Random forest for environmental mixture data. The motivating datasets have neuro-developmental status as responses and metal measurements and demographic variables as covariates. The challenges for variable selections include (1) many measured metal concentrations are highly correlated, (2) there are many possible ways of modeling interactions among the metals, (3) the relationships between the outcomes and explanatory variables are possibly nonlinear, (4) the signal to noise ratio in the real data may be low. To compare these methods ...


Chitosan-Adjuvanted Salmonella Subunit Nanoparticle Vaccine For Poultry Delivered Through Drinking Water And Feed, Sankar Renu, Yi Han, Santosh Dhakal, Yashavanth S. Lakshmanappa, Ninoshkaly Feliciano-Ruiz, Sujata Senapati, Balaji Narasimhan, Ramesh Selvaraj, Gourapura J. Renukaradhya May 2020

Chitosan-Adjuvanted Salmonella Subunit Nanoparticle Vaccine For Poultry Delivered Through Drinking Water And Feed, Sankar Renu, Yi Han, Santosh Dhakal, Yashavanth S. Lakshmanappa, Ninoshkaly Feliciano-Ruiz, Sujata Senapati, Balaji Narasimhan, Ramesh Selvaraj, Gourapura J. Renukaradhya

Chemical and Biological Engineering Publications

Poor induction of mucosal immunity in the intestines by current Salmonella vaccines is a challenge to the poultry industry. We prepared and tested an oral deliverable Salmonella subunit vaccine containing immunogenic outer membrane proteins (OMPs) and flagellin (F) protein loaded and F-protein surface coated chitosan nanoparticles (CS NPs) (OMPs-F-CS NPs). The OMPs-F-CS NPs had mean particle size distribution of 514 nm, high positive charge and spherical in shape. In vitro and in vivo studies revealed the F-protein surface coated CS NPs were specifically targeted to chicken immune cells. The OMPs-F-CS NPs treatment of chicken immune cells upregulated TLRs, and Th1 ...


Implementation Of A Computer-Vision System As A Supportive Diagnostic Tool For Parkinson’S Disease, Diego Machado Reyes May 2020

Implementation Of A Computer-Vision System As A Supportive Diagnostic Tool For Parkinson’S Disease, Diego Machado Reyes

Honors Theses

Parkinson’s disease is the second most common neurodegenerative disorder, affecting nearly 1 million people in the US and it is predicted that the number will keep increasing. Parkinson’s disease is difficult to diagnose due to its similarity with other diseases that share the parkinsonian symptoms and the subjectivity of its assessment, thus increasing the probabilities of misdiagnosis. Therefore, it is relevant to develop diagnostic tools that are quantitatively based and monitoring tools to improve the patient’s quality of life. Computer-based assessment systems have shown to be successful in this field through diverse approaches that can be classified ...


A New Spatially-Resolved Method To Sample Biofilms From Drinking Water Fountains, Yi Liu May 2020

A New Spatially-Resolved Method To Sample Biofilms From Drinking Water Fountains, Yi Liu

Engineering and Applied Science Theses & Dissertations

A drinking fountain, also called a water fountain, is a facility designed to provide drinking water in public space. It consists of a basin and a spout. The users need to bend down to the stream to collect or drink water. The history of water fountains can be traced back to ancient Rome. Even before potable water was provided to individual homes, water for drinking was already made available to citizens through access to public fountains. Nowadays, drinking water fountains usually exist in public places, like schools, hospitals, and libraries. Many jurisdictions in the United States require drinking fountains to ...


Predicting Disease Progression Using Deep Recurrent Neural Networks And Longitudinal Electronic Health Record Data, Seunghwan Kim May 2020

Predicting Disease Progression Using Deep Recurrent Neural Networks And Longitudinal Electronic Health Record Data, Seunghwan Kim

Engineering and Applied Science Theses & Dissertations

Electronic Health Records (EHR) are widely adopted and used throughout healthcare systems and are able to collect and store longitudinal information data that can be used to describe patient phenotypes. From the underlying data structures used in the EHR, discrete data can be extracted and analyzed to improve patient care and outcomes via tasks such as risk stratification and prospective disease management. Temporality in EHR is innately present given the nature of these data, however, and traditional classification models are limited in this context by the cross- sectional nature of training and prediction processes. Finding temporal patterns in EHR is ...


Emergency Eye Simulation Model, Gavin L. Warrington, Christopher Forsyth, Lexus Morris, Natalie Ledezma May 2020

Emergency Eye Simulation Model, Gavin L. Warrington, Christopher Forsyth, Lexus Morris, Natalie Ledezma

Chancellor’s Honors Program Projects

No abstract provided.


A Capacitive Sensing Gym Mat For Exercise Classification & Tracking, Adam Goertz May 2020

A Capacitive Sensing Gym Mat For Exercise Classification & Tracking, Adam Goertz

Computer Science and Computer Engineering Undergraduate Honors Theses

Effective monitoring of adherence to at-home exercise programs as prescribed by physiotherapy protocols is essential to promoting effective rehabilitation and therapeutic interventions. Currently physical therapists and other health professionals have no reliable means of tracking patients' progress in or adherence to a prescribed regimen. This project aims to develop a low-cost, privacy-conserving means of monitoring at-home exercise activity using a gym mat equipped with an array of capacitive sensors. The ability of the mat to classify different types of exercises was evaluated using several machine learning models trained on an existing dataset of physiotherapy exercises.


Characterizing Statin Use Among Prediabetic Patients With Predictive Analytics, Alexandra Gentile May 2020

Characterizing Statin Use Among Prediabetic Patients With Predictive Analytics, Alexandra Gentile

Industrial Engineering Undergraduate Honors Theses

Diabetes is one of the leading causes of death in the United States and can cause severe impairments to those diagnosed. Prediabetes is a state when a patient has higher fasting plasma glucose levels than a non-diabetic person but is not quite high enough to be considered diabetes. Both diabetic and prediabetic patients are at higher risk for cardiovascular diseases (CVD), which is the leading cause of death in the United States. The primary form for prevention and treatment of CVD is through statin therapy. Statins are a class of medications used to treat and prevent CVD by limiting cholesterol ...


Multimodal Photoplethysmography-Based Approaches For Improved Detection Of Hypertension, Kaylie Welykholowa, Richard Fletcher, Mohamed Elgendi Apr 2020

Multimodal Photoplethysmography-Based Approaches For Improved Detection Of Hypertension, Kaylie Welykholowa, Richard Fletcher, Mohamed Elgendi

Open Access Articles

Elevated blood pressure (BP) is a major cause of death, yet hypertension commonly goes undetected. Owing to its nature, it is typically asymptomatic until later in its progression when the vessel or organ structure has already been compromised. Therefore, noninvasive and continuous BP measurement methods are needed to ensure appropriate diagnosis and early management before hypertension leads to irreversible complications. Photoplethysmography (PPG) is a noninvasive technology with waveform morphologies similar to that of arterial BP waveforms, therefore attracting interest regarding its usability in BP estimation. In recent years, wearable devices incorporating PPG sensors have been proposed to improve the early ...


Stationary Exercise Classification Using Imus And Deep Learning, Andrew M. Heroy, Zackary Gill, Samantha Sprague, David Stroud, John Santerre Apr 2020

Stationary Exercise Classification Using Imus And Deep Learning, Andrew M. Heroy, Zackary Gill, Samantha Sprague, David Stroud, John Santerre

SMU Data Science Review

In the current market, successful fitness tracking devices utilize heart rate and GPS to determine performance. These devices are useful, but don't extensively classify stationary exercise. This paper proposes a modern approach for tuning and investigating optimal neural network types on stationary exercises using Inertial Measurement Units (IMUs). Using three IMUs located on the ankle, waist, and wrist, data is collected to map the body as it moves during the stationary physical activity. A novel five-stage deep learning tuning system was written and deployed to classify user movement as one of three classes: air squats, jumping jacks, and kettlebell ...


Proceedings 2020, The Nebraska Academy Of Sciences, Nebraska Academy Of Sciences Apr 2020

Proceedings 2020, The Nebraska Academy Of Sciences, Nebraska Academy Of Sciences

Programs and Proceedings: The Nebraska Academy of Sciences

Presengtations include:

INVERSE KINEMATIC ANALYSIS AND CONTROL SYSTEM DEVELOPMENT FOR REMORA ROBOTIC ARM • PERFORMANCE METRIC EVALUATION AND PATH PLANNING FOR A 6-DOF 3-LEG PARALLEL ROBOT IN RRRS CONFIGURATION • DRAG REDUCTION/ENHANCEMENT USING FEMTOSECOND LASER SURFACE PROCESSING • USE OF FEMTOSECOND LASER SURFACE PROCESSING TO CREATE HIGH EMISSIVTY SURFACES • USING MULTISPECTRAL DRONE IMAGERY TO MEASURE CHANGES IN VEGETATION COVER IN THE NEBRASKA SANDHILLS: PATTERNS IN SPACE AND TIME • DISRUPTING INTER-LIMB COORDINATION THROUGH AN EXOSKELETON DEVICE • ASSESSING LIMB POSITION PERCEPTION WITH AND WITHOUT TACTILE STIMULATION • EXERCISE AND COLD-INDUCED PGC-1 MRNA ISOFORM-SPECIFIC RESPONSE • DIETARY NITRATE INTAKE IMPROVES VASCULAR FUNCTION AND WALKING • CAPACITY IN PATIENTS ...


Spring 2020, Joelle Walls Apr 2020

Spring 2020, Joelle Walls

The Investigator Research Magazine

Dear readers,

We are proud to present the spring issue of The Investigator, giving you an inside look into the varied research and scholarly activities taking place at Kennesaw State.

In a new interview, President Pamela Whitten discusses KSU's growing research reputation and lessons learned from her own experiences as a researcher and mentor. Similarly, our cover story follows three First-Year Scholars as they explore the possibilities of research in Martin Hudson's lab through a new Office of Undergraduate Research initiative.

This publication would not have been possible without the contributions of the editorial team, including undergraduates Kaelyn ...


Measuring Nomophobia And Exploration Of Consequences And Comorbidities, Sarah Marie Fryman, William L. Romine Apr 2020

Measuring Nomophobia And Exploration Of Consequences And Comorbidities, Sarah Marie Fryman, William L. Romine

Symposium of Student Research, Scholarship, and Creative Activities Materials

Excessive use of smartphones has coined the term “Nomophobia”, or fear of not being able to use your smartphone. For many, these devices have become an extension of ourselves, which raises hesitation on whether or not society has become addicted to smartphones. Specific diagnostic criteria for smartphone addiction have yet to be settled, and even appropriate to use the word “addiction” when describing excessive usage of smartphones is controversial.

We therefore explore utilize current measures to explore the symptoms of nomophobia and their hierarchy, as well as comorbidities including social anxiety, self-esteem, distracted driving and sleep quality. A total of ...


How Do Surgeon Preferences And Technique Variances Affect Outcome?, Anastasia Axiopoulou, Caroline G. L. Cao, Katherine Lin Md, Keith Watson Md Apr 2020

How Do Surgeon Preferences And Technique Variances Affect Outcome?, Anastasia Axiopoulou, Caroline G. L. Cao, Katherine Lin Md, Keith Watson Md

Symposium of Student Research, Scholarship, and Creative Activities Materials

The goal of the research project is to create a blue-print of a robot-assisted hysterectomy procedure to support design and evaluation of technology to enhance system performance. To create this blue-print, we will conduct a task analysis, model the cognitive task flow and decision making, and develop a simulation of the hysterectomy procedure. The surgical simulation will be used as a platform to train surgeons on robotic-assisted hysterectomies, as well as to assess learning and performance. Additionally, it will be used to design and develop techniques and novel technology to support surgeons in their performance of the surgery. Current research ...


Identifying Easy Indicators Of Dementia, Swati Padhee, Tanvi Banerjee, Valerie L. Shalin, Krishnaprasad Thirunarayan Apr 2020

Identifying Easy Indicators Of Dementia, Swati Padhee, Tanvi Banerjee, Valerie L. Shalin, Krishnaprasad Thirunarayan

Symposium of Student Research, Scholarship, and Creative Activities Materials

Alzheimer’s Disease (AD) is a degenerative chronic neurodegenerative disease that affects millions of people and whose care costs billions of dollars. There is growing evidence that variations in speech and language may be early indicators of dementia. One of the most initial symptoms of dementia is speech impairment, including difficulty in finding words and changes to the grammatical structure. These early indicators can be detected by having the patients perform a picture description task, such as the Cookie Theft task from the Boston Diagnostic Aphasia Examination. However, much of the state-of-the-art NLP for dementia has been limited due to ...


Predicting Alcohol Withdrawal In Intensive Care Units, Reza Sadeghi, Tanvi Banerjee, William L. Romine Apr 2020

Predicting Alcohol Withdrawal In Intensive Care Units, Reza Sadeghi, Tanvi Banerjee, William L. Romine

Symposium of Student Research, Scholarship, and Creative Activities Materials

Alcohol use disorder is a common health issue in older adults who are facing depression caused by retirement, loss of a spouse, pain, and sleep problems. The prolonged, heavy alcohol ingestion will lead to high alcohol dependency such that cessation or reduction of using alcohol causes alcohol withdrawal syndrome (AWS) in roughly 4 to 72 hours after the last drink. During the initial 8 hours, patients face anxiety, insomnia, nausea, and abdominal pain. This condition is followed by high blood pressure, increased body temperature, unusual heart rate, and confusion. If this syndrome does not receive any treatment, the patients will ...


Team Creation Methods In Practice: Understanding The Potential Effects Of Nonverbal Communication In The Leadership Of Team Formation, Troy Allen Robertson Apr 2020

Team Creation Methods In Practice: Understanding The Potential Effects Of Nonverbal Communication In The Leadership Of Team Formation, Troy Allen Robertson

Dissertations

Teams require leadership, even if they are self-managed. The group of individuals who make up a team must be gathered in some form or another. For self managed teams to function successfully, the first step is the process of creating the team. Many aspects may factor into the creation process. Often time is of the essence and methods to quickly assess and form teams show merit. First impressions in general are based largely on nonverbal communication. The focus of this mixed-methods concurrent embedded study is to analyze the potential effects of nonverbal communication on influencing team creation. A group of ...


Supercavitation Capabilities On A Submarine, Adam Vu Mar 2020

Supercavitation Capabilities On A Submarine, Adam Vu

Georgia College Student Research Events

Submarines have shaped the way wars have been fought and have been influential in our understanding of fluid dynamics. In the past, supercavitation has been implemented to an idea that has been used to significantly increase the velocity of torpedoes in Chinese and Russian submarines. An example of this is the Russian VA-111 Shkval torpedo. The idea being that if your torpedo is expelling a gas out of the nose cone region, creating a boundary layer between the water and the torpedo, the torpedo will be facing much less resistance relative to when it was traveling in water alone. This ...


Machine Learning Towards General Medical Image Segmentation, Clara Tam Mar 2020

Machine Learning Towards General Medical Image Segmentation, Clara Tam

Electronic Thesis and Dissertation Repository

The quality of patient care associated with diagnostic radiology is proportionate to a physician's workload. Segmentation is a fundamental limiting precursor to diagnostic and therapeutic procedures. Advances in machine learning aims to increase diagnostic efficiency to replace single applications with generalized algorithms. We approached segmentation as a multitask shape regression problem, simultaneously predicting coordinates on an object's contour while jointly capturing global shape information. Shape regression models inherent point correlations to recover ambiguous boundaries not supported by clear edges and region homogeneity. Its capabilities was investigated using multi-output support vector regression (MSVR) on head and neck (HaN) CT ...


Cuffless Single-Site Photoplethysmography For Blood Pressure Monitoring, Manish Hosanee, Richard Fletcher, Mohamed Elgendi Mar 2020

Cuffless Single-Site Photoplethysmography For Blood Pressure Monitoring, Manish Hosanee, Richard Fletcher, Mohamed Elgendi

Open Access Articles

One in three adults worldwide has hypertension, which is associated with significant morbidity and mortality. Consequently, there is a global demand for continuous and non-invasive blood pressure (BP) measurements that are convenient, easy to use, and more accurate than the currently available methods for detecting hypertension. This could easily be achieved through the integration of single-site photoplethysmography (PPG) readings into wearable devices, although improved reliability and an understanding of BP estimation accuracy are essential. This review paper focuses on understanding the features of PPG associated with BP and examines the development of this technology over the 2010-2019 period in terms ...


Development And Testing Of Novel Antimicrobial Materials For Additive Manufacturing With Application In Space, Michael Thompson, Jorge Zuniga, Christopher Copeland, Roberto Saavedra, Claudia Cortes Reyes, Andres Acuña Velásquez, Daniel Martínez Pereira, Claudio Soto Mar 2020

Development And Testing Of Novel Antimicrobial Materials For Additive Manufacturing With Application In Space, Michael Thompson, Jorge Zuniga, Christopher Copeland, Roberto Saavedra, Claudia Cortes Reyes, Andres Acuña Velásquez, Daniel Martínez Pereira, Claudio Soto

Student Research and Creative Activity Fair

PURPOSE: The purpose of the study was twofold: (i) develop and test the antimicrobial properties of a polylactic acid- and a polyurethane-based filament, and (ii) use these filaments to manufacture a socket-based prosthesis to verify printability and longevity of the antimicrobial properties. It was hypothesized that the formulation of a novel biocidal copper-based nanocomposite with a biocompatible 3D printing polymer/copolymer can be used for the development of antimicrobial medical devices to mitigate microbial risks during long space flight missions [1, 2, 3].

METHODS: Polylactic Acid-based Filament Development-The development of a polylactic acid-based filament involved several processes, such as ...


Gesea Biosciences - Core Shell Pellet Manufacturing Device, Claire Edelman, Maria Medrano, Rachel Longoria Mar 2020

Gesea Biosciences - Core Shell Pellet Manufacturing Device, Claire Edelman, Maria Medrano, Rachel Longoria

Biomedical Engineering

No abstract provided.


Left Atrial Appendage Printing Process, Areli Reyes, Brandon James Mukai, Mia Noelle Von Knorring Mar 2020

Left Atrial Appendage Printing Process, Areli Reyes, Brandon James Mukai, Mia Noelle Von Knorring

Biomedical Engineering

The left atrial appendage senior design team aims to assist in closing off the left atrial appendage that is susceptible to coagulation due to non-valvular atrial fibrillation. Coagulation in the left atrial appendage (LAA) can be life threatening as it can lead to a stroke. Dr. Chris Porterfield performs a procedure that uses the Boston Scientific Watchman to close the appendage. He finds that sizing the Watchman properly is difficult with limited visuals from live CT scans. He proposed converting the CT scans into a 3D printed model of the left atrial appendage and left atrium so he can visually ...


Working Across Disciplines And Library Units To Develop A Suite Of Systematic Review Services For Researchers, Nedelina Tchangalova, Eileen G. Harrington, Stephanie Ritchie, Sarah Over, Jodi Coalter Feb 2020

Working Across Disciplines And Library Units To Develop A Suite Of Systematic Review Services For Researchers, Nedelina Tchangalova, Eileen G. Harrington, Stephanie Ritchie, Sarah Over, Jodi Coalter

Collaborative Librarianship

Since their inception in the health sciences field, systematic reviews have expanded into many other subject disciplines. To address this growing need, subject librarians at the University of Maryland Libraries collaborated on a pilot program in three phases to introduce researchers to the process of conducting systematic and scoping reviews. This article describes the development of various collaborative efforts leading to the implementation of a systematic review service based on participant feedback. Assessment and evaluation techniques are shared to encourage further refinement of the systematic review service.


Proceedings Of The Cuny Games Conference 6.0, Robert O. Duncan, Joseph Bisz, Christina Boyle, Kathleen Offenholley, Maura A. Smale, Carolyn Stallard, Deborah Sturm Feb 2020

Proceedings Of The Cuny Games Conference 6.0, Robert O. Duncan, Joseph Bisz, Christina Boyle, Kathleen Offenholley, Maura A. Smale, Carolyn Stallard, Deborah Sturm

Publications and Research

The CUNY Games Network is an organization dedicated to encouraging research, scholarship and teaching in the developing field of games-based learning. We connect educators from every campus and discipline at CUNY and beyond who are interested in digital and non-digital games, simulations, and other forms of interactive teaching and inquiry-based learning. These proceedings summarize the CUNY Games Conference 6.0, where scholars shared research findings at a three-day event to promote and discuss game-based pedagogy in higher education. Presenters could share findings in oral presentations, posters, demos, or play testing sessions. The conference also included workshops on how to modify ...


Arranged Marriages: An Inappropriate Fabrication, Karika Sethi, Michael D. Reiter Feb 2020

Arranged Marriages: An Inappropriate Fabrication, Karika Sethi, Michael D. Reiter

Mako: NSU Undergraduate Student Journal

This paper explores what an inappropriate relationship is and the taxonomy scale used to evaluate different relationships, specifically, arranged marriages. Arranged marriage is a topic that is considered taboo depending on global location. It is more prevalent in Eastern nations such as India, China, Oriental countries, and the Middle East. However, Western influence plays a significant role on what is and is not acceptable, as societal norms differ from place to place. What is defined as normal by culture is what helps to define if a relationship is or is not viewed as inappropriate. This paper is designed to explore ...


A Single Dose Polyanhydride-Based Nanovaccine Against Paratuberculosis Infection, Akanksha Thukral, Kathleen Ross, Chungyi Hansen, Yashdeep Phanse, Balaji Narasimhan, Howard Steinberg, Adel M. Talaat Feb 2020

A Single Dose Polyanhydride-Based Nanovaccine Against Paratuberculosis Infection, Akanksha Thukral, Kathleen Ross, Chungyi Hansen, Yashdeep Phanse, Balaji Narasimhan, Howard Steinberg, Adel M. Talaat

Chemical and Biological Engineering Publications

Mycobacterium avium subsp. paratuberculosis (M. paratuberculosis) causes Johne’s disease in ruminants and is characterized by chronic gastroenteritis leading to heavy economic losses to the dairy industry worldwide. The currently available vaccine (inactivated bacterin in oil base) is not effective in preventing pathogen shedding and is rarely used to control Johne’s disease in dairy herds. To develop a better vaccine that can prevent the spread of Johne’s disease, we utilized polyanhydride nanoparticles (PAN) to encapsulate mycobacterial antigens composed of whole cell lysate (PAN-Lysate) and culture filtrate (PAN-Cf) of M. paratuberculosis. These nanoparticle-based vaccines (i.e., nanovaccines) were well ...


The Potential For Autonomous Vehicle Technologies To Address Barriers To Driving For Individuals With Autism, Caroline Rodier Feb 2020

The Potential For Autonomous Vehicle Technologies To Address Barriers To Driving For Individuals With Autism, Caroline Rodier

Mineta Transportation Institute Publications

Individuals with autism represent a sizeable share of the U.S. population (almost 2%), and nearly half of those with autism have average to high levels of intelligence. However, available research shows that adults with autism have a much more difficult time becoming employed and living independently compared to both typically developing adults and adults with disabilities. This study reviews the available literature on the magnitude of challenges to driving and accessing essential opportunities for adults with autism, and the potential of autonomous vehicles to address those challenges. This study is unique in that it identifies the specific driving challenges ...


Multimodal Multiplexed Immunoimaging With Nanostars To Detect Multiple Immunomarkers And Monitor Response To Immunotherapies, Yu-Chuan Ou, Xiaona Wen, Christopher A. Johnson, Daniel Shae, Oscar D. Ayala, Joseph A. Webb, Eugene C. Lin, Rossane C. Delapp, Kelli L. Boyd, Ann Richmond, Anita Mahadevan-Jansen, Marjan Rafat, John T. Wilson, Justin M. Balko, Mohammed N. Tantawy, Anna E. Vilgelm, Rizia Bardhan Jan 2020

Multimodal Multiplexed Immunoimaging With Nanostars To Detect Multiple Immunomarkers And Monitor Response To Immunotherapies, Yu-Chuan Ou, Xiaona Wen, Christopher A. Johnson, Daniel Shae, Oscar D. Ayala, Joseph A. Webb, Eugene C. Lin, Rossane C. Delapp, Kelli L. Boyd, Ann Richmond, Anita Mahadevan-Jansen, Marjan Rafat, John T. Wilson, Justin M. Balko, Mohammed N. Tantawy, Anna E. Vilgelm, Rizia Bardhan

Chemical and Biological Engineering Publications

The overexpression of immunomarker programmed cell death protein 1 (PD-1) and engagement of PD-1 to its ligand, PD-L1, are involved in the functional impairment of cluster of differentiation 8+ (CD8+) T cells, contributing to cancer progression. However, heterogeneities in PD-L1 expression and variabilities in biopsy-based assays render current approaches inaccurate in predicting PD-L1 status. Therefore, PD-L1 screening alone is not predictive of patient response to treatment, which motivates us to simultaneously detect multiple immunomarkers engaged in immune modulation. Here, we have developed multimodal probes, immunoactive gold nanostars (IGNs), that accurately detect PD-L1+ tumor cells and CD8+ T cells simultaneously in ...


Barn-Raising On The Digital Frontier: The L.A.U.N.C.H. Collaborative, Bradford W. Hesse, David Ahern, Michele Ellison, Eliah Aronoff-Spencer, Robin C. Vanderpool, Karen Onyeije, Michael C. Gibbons, Timothy W. Mullett, Ming-Yuan Chih, Victoria Attencio, Grant Patterson, Jessica Boten, Christopher Hartshorn, Ben Bartolome, Katie Gorscak, Melanie Mccomsey, Alexandra Hubenko, Bin Huang, Corey Baker, Don Norman Jan 2020

Barn-Raising On The Digital Frontier: The L.A.U.N.C.H. Collaborative, Bradford W. Hesse, David Ahern, Michele Ellison, Eliah Aronoff-Spencer, Robin C. Vanderpool, Karen Onyeije, Michael C. Gibbons, Timothy W. Mullett, Ming-Yuan Chih, Victoria Attencio, Grant Patterson, Jessica Boten, Christopher Hartshorn, Ben Bartolome, Katie Gorscak, Melanie Mccomsey, Alexandra Hubenko, Bin Huang, Corey Baker, Don Norman

Journal of Appalachian Health

A meta-analysis of oncology papers from around the world revealed that cancer patients who lived more than 50 miles away from hospital centers routinely presented with more advanced stages of disease at diagnosis, exhibited lower adherence to prescribed treatments, presented with poorer diagnoses, and reported a lower quality of life than patients who lived nearer to care facilities. Connected health approaches—or the use of broadband and telecommunications technologies to evaluate, diagnose, and monitor patients beyond the clinic—are becoming an indispensable tool in medicine to overcome the obstacle of distance.