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Articles 1 - 30 of 34
Full-Text Articles in Engineering
Molecular Separation By Using Active And Passive Microfluidic Chip Designs: A Comprehensive Review, A. Ebrahimi, K. Icoz, R. Didarian, C.-H. Shih, A. Akpek, Berivan Cecen, Sabanci A. Bal-Ozturk, K. Güleç, Y.-C.E Li, S. Shih, B. Sirma Tarim, H.C. Tekin, E. Alarçin, H. Ghorbanpoor, C. Özel, A. Eker Sarıboyacı, Guzel F. Dogan, N. Bassous, S.R. Shin, H. Avci
Molecular Separation By Using Active And Passive Microfluidic Chip Designs: A Comprehensive Review, A. Ebrahimi, K. Icoz, R. Didarian, C.-H. Shih, A. Akpek, Berivan Cecen, Sabanci A. Bal-Ozturk, K. Güleç, Y.-C.E Li, S. Shih, B. Sirma Tarim, H.C. Tekin, E. Alarçin, H. Ghorbanpoor, C. Özel, A. Eker Sarıboyacı, Guzel F. Dogan, N. Bassous, S.R. Shin, H. Avci
Henry M. Rowan College of Engineering Faculty Scholarship
Separation and identification of molecules and biomolecules such as nucleic acids, proteins, and polysaccharides from complex fluids are known to be important due to unmet needs in various applications. Generally, many different separation techniques, including chromatography, electrophoresis, and magnetophoresis, have been developed to identify the target molecules precisely. However, these techniques are expensive and time consuming. “Lab-on-a-chip” systems with low cost per device, quick analysis capabilities, and minimal sample consumption seem to be ideal candidates for separating particles, cells, blood samples, and molecules. From this perspective, different microfluidic-based techniques have been extensively developed in the past two decades to separate …
Strategic Optimization Of The Flushing Operations In Lubricant Manufacturing And Packaging Facilities, Swapana Jerpoth, Robert Hesketh, C. Stewart Slater, Mariano Savelski, Kirti Maheshkumar Yenkie
Strategic Optimization Of The Flushing Operations In Lubricant Manufacturing And Packaging Facilities, Swapana Jerpoth, Robert Hesketh, C. Stewart Slater, Mariano Savelski, Kirti Maheshkumar Yenkie
Henry M. Rowan College of Engineering Faculty Scholarship
Commercial lubricant industries use a complex pipeline network for the sequential processing of thousands of unique products annually. Flushing is conducted between changeovers to ensure the integrity of each production batch. An upcoming product is used for cleaning the residues of the previous batch, resulting in the formation of a commingled/mixed oil that does not match the specifications of either of the two batches. The existing operations are based on the operator’s experience and trial and error. After a selected flush time, the samples are tested for their viscosity to determine the success of a flush. The approach results in …
Enhanced Cell Viability And Migration Of Primary Bovine Annular Fibrosus Fibroblast-Like Cells Induced By Microsecond Pulsed Electric Field Exposure, Prince M. Atsu, Connor Mowen, Gary L. Thompson Iii
Enhanced Cell Viability And Migration Of Primary Bovine Annular Fibrosus Fibroblast-Like Cells Induced By Microsecond Pulsed Electric Field Exposure, Prince M. Atsu, Connor Mowen, Gary L. Thompson Iii
Henry M. Rowan College of Engineering Faculty Scholarship
This study is the first to report the enhancement of cell migration and proliferation induced by in vitro microsecond pulsed electric field (μsPEF) exposure of primary bovine annulus fibrosus (AF) fibroblast-like cells. AF primary cells isolated from fresh bovine intervertebral disks (IVDs) are exposed to 10 and 100 μsPEFs with different numbers of pulses and applied electric field strengths. The results indicate that 10 μs-duration pulses induce reversible electroporation, while 100 μs pulses induce irreversible electroporation of the cells. Additionally, μsPEF exposure increased AF cell proliferation up to 150% while increasing the average migration speed by 0.08 μm/min over 24 …
Threshold Microsecond Pulsed Electric Field Exposures For Change In Spinach Quality, Zachary Rosensweig, Abigail Martin, Colin Hackett, Jerrick Garcia, Gary L. Thompson Iii
Threshold Microsecond Pulsed Electric Field Exposures For Change In Spinach Quality, Zachary Rosensweig, Abigail Martin, Colin Hackett, Jerrick Garcia, Gary L. Thompson Iii
Henry M. Rowan College of Engineering Faculty Scholarship
Pulsed electric fields (PEFs) are often used to pretreat foods to enhance subsequent processes, such as drying, where maintaining food product quality is important for consumer satisfaction. This study aims to establish a threshold PEF exposure to determine the doses at which electroporation is viable for use on spinach leaves, wherein integrity is maintained postexposure. Three numbers of consecutive pulses (1, 5, 50) and two pulse durations (10 and 100 μs) have been examined herein at a constant pulse repetition of 10 Hz and 1.4 kV/cm field strength. The data indicate that pore formation in itself is not a cause …
Sustainable Design And Systems Medicine Laboratory, Kirti Maheshkumar Yenkie
Sustainable Design And Systems Medicine Laboratory, Kirti Maheshkumar Yenkie
Henry M. Rowan College of Engineering Faculty Scholarship
No abstract provided.
Histone Deacetylase 4 And 5 Translocation Elicited By Microsecond Pulsed Electric Field Exposure Is Mediated By Kinase Activity, Zahra Safaei, Gary L. Thompson Iii
Histone Deacetylase 4 And 5 Translocation Elicited By Microsecond Pulsed Electric Field Exposure Is Mediated By Kinase Activity, Zahra Safaei, Gary L. Thompson Iii
Henry M. Rowan College of Engineering Faculty Scholarship
Electroporation-based technologies using microsecond pulsed electric field (µsPEF) exposures are established as laboratory and clinical tools that permeabilize cell membranes. We demonstrate a µsPEF bioeffect on nucleocytoplasmic import and export of enzymes that regulate genetic expression, histone deacetylases (HDAC) -4 and -5. Their μsPEF-induced nucleocytoplasmic transport depends on presence and absence of extracellular calcium ions (Ca2+) for both MCF7 and CHO-K1 cells. Exposure to 1, 10, 30 and 50 consecutive square wave pulses at 1 Hz and of 100 µs duration with 1.45 kV/cm magnitude leads to translocation of endogenous HDAC4 and HDAC5. We posit that by eliciting a rise …
Design Of Solvent-Assisted Plastics Recycling: Integrated Economics And Environmental Impacts Analysis, Austin L. Lehr, Kayla L. Heider, Emmanuel A. Aboagye, John D. Chea, Jake P. Stengel, Pahola T. Benavides, Kirti Maheshkumar Yenkie
Design Of Solvent-Assisted Plastics Recycling: Integrated Economics And Environmental Impacts Analysis, Austin L. Lehr, Kayla L. Heider, Emmanuel A. Aboagye, John D. Chea, Jake P. Stengel, Pahola T. Benavides, Kirti Maheshkumar Yenkie
Henry M. Rowan College of Engineering Faculty Scholarship
In 2018, the United States generated over 35. 7 million tons of plastic waste, with only 8.4% being recycled and the other 91.6% incinerated or disposed of in a landfill. The continued growth of the polymer market has raised concerns over the end of life of plastics. Currently, the waste management system is faced with issues of inefficient sorting methods and low-efficiency recycling methods when it comes to plastics recycling. Mechanical recycling is the commonest recycling method but presents a lower-valued recycled material due to the material incompatibilities introduced via the inefficient sorting methods. Chemical recycling offers a promising alternative …
Design Of Solvent-Assisted Plastics Recycling: Integrated Economics And Environmental Impacts Analysis, Austin L. Lehr, Kayla L. Heider, Emmanuel A. Aboagye, John D. Chea, Jake P. Stengel, Pahola Thathiana Benavides, Kirti M. Yenkie
Design Of Solvent-Assisted Plastics Recycling: Integrated Economics And Environmental Impacts Analysis, Austin L. Lehr, Kayla L. Heider, Emmanuel A. Aboagye, John D. Chea, Jake P. Stengel, Pahola Thathiana Benavides, Kirti M. Yenkie
Henry M. Rowan College of Engineering Faculty Scholarship
In 2018, the United States generated over 35. 7 million tons of plastic waste, with only 8.4% being recycled and the other 91.6% incinerated or disposed of in a landfill. The continued growth of the polymer market has raised concerns over the end of life of plastics. Currently, the waste management system is faced with issues of inefficient sorting methods and low-efficiency recycling methods when it comes to plastics recycling. Mechanical recycling is the commonest recycling method but presents a lower-valued recycled material due to the material incompatibilities introduced via the inefficient sorting methods. Chemical recycling offers a promising alternative …
Impurity Incorporation In Solution Crystallization: Diagnosis, Prevention, And Control, Gerard Capellades, Jacob O. Bonsu, Allan S. Myerson
Impurity Incorporation In Solution Crystallization: Diagnosis, Prevention, And Control, Gerard Capellades, Jacob O. Bonsu, Allan S. Myerson
Henry M. Rowan College of Engineering Faculty Scholarship
Despite their widespread use for purification, our current methods for the development of solution crystallization processes lack a sufficient understanding on how impurities incorporate in growing crystals. This is, in part, due to the large number of mechanisms often encountered for impurity incorporation, and due to limitations in our methods for diagnosis of those mechanisms. These limitations propagate into largely empirical process development strategies, which are still based on trial and error and centered on solvent selection. This manuscript highlights recent developments in the diagnosis, prevention, and control of impurity incorporation during batch and continuous crystallization. The goal is to …
Systems Level Roadmap For Solvent Recovery And Reuse In Industries, Emmanuel A. Aboagye, John D. Chea, Kirti M. Yenkie
Systems Level Roadmap For Solvent Recovery And Reuse In Industries, Emmanuel A. Aboagye, John D. Chea, Kirti M. Yenkie
Henry M. Rowan College of Engineering Faculty Scholarship
Recovering waste solvent for reuse presents an excellent alternative to improving the greenness of industrial processes. Implementing solvent recovery practices in the chemical industry is necessary, given the increasing focus on sustainability to promote a circular economy. However, the systematic design of recovery processes is a daunting task due to the complexities associated with waste stream composition, techno-economic analysis, and environmental assessment. Furthermore, the challenges to satisfy the desired product specifications, particularly in pharmaceuticals and specialty chemical industries, may also deter solvent recovery and reuse practices. To this end, this review presents a systems-level approach including various methodologies that can …
Synthesis And Characterization Of A Low-Molecular-Weight Novolac Epoxy Derived From Lignin-Inspired Phenolics., Kelli M Hambleton, Joseph F. Stanzione Iii
Synthesis And Characterization Of A Low-Molecular-Weight Novolac Epoxy Derived From Lignin-Inspired Phenolics., Kelli M Hambleton, Joseph F. Stanzione Iii
Henry M. Rowan College of Engineering Faculty Scholarship
The need for renewable polymers capable of replacing their petrochemical counterparts continues to grow as sustainability concerns rise. Bisguaiacol (BG), a bioinspired alternative to bisphenol-A (BPA), has been synthesized using vanillyl alcohol and guaiacol via an electrophilic aromatic condensation. Purification provides both BG and an oligomeric coproduct with a consistent number average molecular weight and dispersity of ∼650 Da and ∼1.00, respectively. This coproduct has been well characterized as a low-molecular-weight novolac averaging five hydroxyls per molecule and was transformed into an epoxy resin suitable for use in thermosetting resins. The bioinspired thermoset produced in this work, consisting of the …
Integrating Design Thinking In Chemical Engineering Coursework For Enhanced Student Learning, J. P. Stengel, S. S. Jerpoth, Kirti M. Yenkie
Integrating Design Thinking In Chemical Engineering Coursework For Enhanced Student Learning, J. P. Stengel, S. S. Jerpoth, Kirti M. Yenkie
Henry M. Rowan College of Engineering Faculty Scholarship
In the engineering discipline, it is of utmost importance to give value to applied learning because as engineers, we are expected to innovate, and innovations happen when theoretical ideas are implemented successfully. Design thinking is one such approach that can enhance the value of theoretical concepts and motivate the students to visualize their ideas in more meaningful ways. The five stages of design thinking include: (i) Empathize, (ii) Define, (iii) Ideate, (iv) Prototype, and (v) Test. The traditional engineering curriculum focuses on the last four stages and thus leads to a skewed perspective among students with regards to problem definition, …
Hydrophilic Modification Of Sla 3d Printed Droplet Generators By Photochemical Grafting, Tristan W. Bacha, Dylan C. Manuguerra, Robert A. Marano, Joseph F. Stanzione Iii
Hydrophilic Modification Of Sla 3d Printed Droplet Generators By Photochemical Grafting, Tristan W. Bacha, Dylan C. Manuguerra, Robert A. Marano, Joseph F. Stanzione Iii
Henry M. Rowan College of Engineering Faculty Scholarship
Few droplet generators manufactured using desktop stereolithography 3D printers have been reported in the literature. Moreover, 3D printed microfluidic chips are typically hydrophobic, limiting their application to water in oil droplets. Herein, we present designs for concentric and planar 3D printed microfluidic devices suitable for making polymeric microparticles using an off-the-shelf commercial stereolithography printer and resin. The devices consist of a microscope slide, binder clips, and printed components. Channels were modified by an ultraviolet grafting of methacrylic acid to the surface of chips, yielding a hydrophilic coating without modification to the bulk polymer. The water contact angle decreased from 97.0° …
Teaching Sustainable Design Through Simultaneous Evaluation Of Economics And Environmental Impacts, Kirti M. Yenkie, J. D. Chea, E. A. Aboagye, Mariano J. Savelski, C. Stewart Slater
Teaching Sustainable Design Through Simultaneous Evaluation Of Economics And Environmental Impacts, Kirti M. Yenkie, J. D. Chea, E. A. Aboagye, Mariano J. Savelski, C. Stewart Slater
Henry M. Rowan College of Engineering Faculty Scholarship
The ever-increasing human population and industrial growth have posed a considerable burden on existing resources and have led to an increase in environmental pollution and climate change. The Engineering Clinics offered at the Henry M. Rowan College of Engineering at Rowan University is the hallmark of our program that enables our undergraduate students to actively participate in solving real-world problems through collaborative activities. Our graduate students get an opportunity to engage in stakeholder (i.e., industries, federal and regional funding agencies) interactions and student mentoring in conjunction with developing their research ability. Thus, through these synergistic undergraduate-graduate-faculty- stakeholder collaborations this work …
Systematic Design, Optimization, And Sustainability Assessment For Generation Of Efficient Wastewater Treatment Networks, Kirti Maheshkumar Yenkie, Emmanuel A Aboagye, Sean M. Burnham, James Dailey, Rohan Zia, Carley Tran, Maya Desai
Systematic Design, Optimization, And Sustainability Assessment For Generation Of Efficient Wastewater Treatment Networks, Kirti Maheshkumar Yenkie, Emmanuel A Aboagye, Sean M. Burnham, James Dailey, Rohan Zia, Carley Tran, Maya Desai
Henry M. Rowan College of Engineering Faculty Scholarship
Due to population growth and economic development, there has been an increase in global wastewater (WW) generation footprint. There are different technologies associated with the wastewater treatment (WWT) process. The challenge is to select technologies that minimize the cost of treatment, as well as meet purity requirements. Further, there is a need to integrate sustainability analysis to facilitate a holistic decision. With the application of systems engineering, sustainable and cost-effective solutions can be achieved. In this work, we apply systems engineering to generate a sustainable and cost-effective solution. A superstructure was generated by categorizing technologies into four treatment stages. After …
Developing Eco-Friendly And Cost-Effective Porous Adsorbent For Carbon Dioxide Capture., Mahboubeh Nabavinia, Baishali Kanjilal, Noahiro Fujinuma, Amos Mugweru, Iman Noshadi
Developing Eco-Friendly And Cost-Effective Porous Adsorbent For Carbon Dioxide Capture., Mahboubeh Nabavinia, Baishali Kanjilal, Noahiro Fujinuma, Amos Mugweru, Iman Noshadi
Henry M. Rowan College of Engineering Faculty Scholarship
To address the issue of global warming and climate change issues, recent research efforts have highlighted opportunities for capturing and electrochemically converting carbon dioxide (CO2). Despite metal doped polymers receiving widespread attention in this respect, the structures hitherto reported lack in ease of synthesis with scale up feasibility. In this study, a series of mesoporous metal-doped polymers (MRFs) with tunable metal functionality and hierarchical porosity were successfully synthesized using a one-step copolymerization of resorcinol and formaldehyde with Polyethyleneimine (PEI) under solvothermal conditions. The effect of PEI and metal doping concentrations were observed on physical properties and adsorption results. The results …
Impact Of Critical Material Attributes (Cmas)-Particle Shape On Miniature Pharmaceutical Unit Operations., Mohammad A Azad, Gerard Capellades, Allison B Wang, David M Klee, Gregory Hammersmith, Kersten Rapp, David Brancazio, Allan S Myerson
Impact Of Critical Material Attributes (Cmas)-Particle Shape On Miniature Pharmaceutical Unit Operations., Mohammad A Azad, Gerard Capellades, Allison B Wang, David M Klee, Gregory Hammersmith, Kersten Rapp, David Brancazio, Allan S Myerson
Henry M. Rowan College of Engineering Faculty Scholarship
The U.S. Food and Drug Administration (FDA) emphasizes drug product development by Quality by Design (QbD). Critical material attributes (CMAs) are a QbD element that has an impact on pharmaceutical operations and product quality. Pharmaceutical drugs often crystallize as needle-shaped (a CMA) particles and affect the process due to poor flowability, low bulk density, and high compressibility, and eventually the product performance. In this study, the product obtained from crystallization was needle-shaped Ciprofloxacin HCl (CIPRO), formed lumps during drying, and compacted during processing through feeders. To delump small amounts of materials and break the needles, multiple available devices (mortar-pestle, Krups …
Stabilizing Liquid Drops In Nonequilibrium Shapes By The Interfacial Crosslinking Of Nanoparticles, Mohd A. Kahn, Martin F. Haase
Stabilizing Liquid Drops In Nonequilibrium Shapes By The Interfacial Crosslinking Of Nanoparticles, Mohd A. Kahn, Martin F. Haase
Henry M. Rowan College of Engineering Faculty Scholarship
Droplets are spherical due to the principle of interfacial energy minimization. Here, we show that nonequilibrium droplet shapes can be stabilized via the interfacial self-assembly and crosslinking of nanoparticles. This principle allows for the stability of practically infinitely long liquid tubules and monodisperse cylindrical droplets. Droplets of oil-in-water are elongated via gravitational or hydrodynamic forces at a reduced interfacial tension. Silica nanoparticles self-assemble and cross-link on the interface triggered by the synergistic surface modification with hexyltrimethylammonium- and trivalent lanthanum-cations. The droplet length dependence is described by a scaling relationship and the rate of nanoparticle deposition on the droplets is estimated. …
Effect Of Microcapsule Content On Diels-Alder Room Temperature Self-Healing Thermosets., Sadella C Santos, John J La Scala, Giuseppe R Palmese
Effect Of Microcapsule Content On Diels-Alder Room Temperature Self-Healing Thermosets., Sadella C Santos, John J La Scala, Giuseppe R Palmese
Henry M. Rowan College of Engineering Faculty Scholarship
A furan functionalized epoxy-amine thermoset with an embedded microcapsule healing system that utilizes reversible Diels-Alder healing chemistry was used to investigate the influence of microcapsule loading on healing efficiency. A urea-formaldehyde encapsulation technique was used to create capsules with an average diameter of 150 µm that were filled with a reactive solution of bismaleimide in phenyl acetate. It was found that optimum healing of the thermoset occurred at 10 wt% microcapsule content for the compositions investigated. The diffusion of solvent through the crack interface and within fractured samples was investigated using analytical diffusion models. The decrease in healing efficiency at …
Epoxidation Of Cardanol's Terminal Double Bond., Emre Kinaci, Erde Can, John J La Scala, Giuseppe R Palmese
Epoxidation Of Cardanol's Terminal Double Bond., Emre Kinaci, Erde Can, John J La Scala, Giuseppe R Palmese
Henry M. Rowan College of Engineering Faculty Scholarship
In this investigation, the terminal double bonds of the side chain epoxidized cardanol glycidyl ether (SCECGE) molecule were further epoxidized in the presence of Oxone® (potassium peroxomonosulfate) and fluorinated acetone. Regular methods for the double bond epoxidation are not effective on the terminal double bonds because of their reduced electronegativity with respect to internal double bonds. The terminal double bond functionality of the SCECGE was epoxidized to nearly 70%, increasing the epoxy functionality of SCECGE from 2.45 to 2.65 epoxies/molecule as measured using proton magnetic nuclear resonance (1H-NMR). This modified material—side chain epoxidized cardanol glycidyl ether with terminal epoxies (TE-SCECGE)—was …
Formulation Of A Model Resin System For Benchmarking Processing-Property Relationships In High-Performance Photo 3d Printing Applications., Jianwei Tu, Kamran Makarian, Nicolas J Alvarez, Giuseppe R Palmese
Formulation Of A Model Resin System For Benchmarking Processing-Property Relationships In High-Performance Photo 3d Printing Applications., Jianwei Tu, Kamran Makarian, Nicolas J Alvarez, Giuseppe R Palmese
Henry M. Rowan College of Engineering Faculty Scholarship
A well-defined resin system is needed to serve as a benchmark for 3D printing of high-performance composites. This work describes the design and characterization of such a system that takes into account processability and performance considerations. The Grunberg–Nissan model for resin viscosity and the Fox equation for polymer Tg were used to determine proper monomer ratios. The target viscosity of the resin was below 500 cP, and the target final Tg of the cured polymer was 150 °C based on tan-δ peak from dynamic mechanical analysis. A tri-component model resin system, termed DA-2 resin, was determined and fully characterized. The …
Influence Of Epoxidized Cardanol Functionality And Reactivity On Network Formation And Properties., Emre Kinaci, Erde Can, John J La Scala, Giuseppe R Palmese
Influence Of Epoxidized Cardanol Functionality And Reactivity On Network Formation And Properties., Emre Kinaci, Erde Can, John J La Scala, Giuseppe R Palmese
Henry M. Rowan College of Engineering Faculty Scholarship
Cardanol is a renewable resource based on cashew nut shell liquid (CNSL), which consists of a phenol ring with a C15 long aliphatic side chain in the meta position with varying degrees of unsaturation. Cardanol glycidyl ether was chemically modified to form side-chain epoxidized cardanol glycidyl ether (SCECGE) with an average epoxy functionality of 2.45 per molecule and was cured with petroleum-based epoxy hardeners, 4-4'-methylenebis(cyclohexanamine) and diethylenetriamine, and a cardanol-based amine hardener. For comparison, cardanol-based diphenol diepoxy resin, NC514 (Cardolite), and a petroleum-based epoxy resin, diglycidyl ether of bisphenol-A (DGEBA) were also evaluated. Chemical and thermomechanical analyses showed that for …
High‐Tensile Strength, Composite Bijels Through Microfluidic Twisting, S. P. Kharal, Robert P. Hesketh, Martin F. Haase
High‐Tensile Strength, Composite Bijels Through Microfluidic Twisting, S. P. Kharal, Robert P. Hesketh, Martin F. Haase
Henry M. Rowan College of Engineering Faculty Scholarship
Rope making is a millennia old technique to collectively assemble numerous weak filaments into flexible and high tensile strength bundles. However, delicate soft matter fibers lack the robustness to be twisted into bundles by means of mechanical rope making tools. Here, weak microfibers with tensile strengths of a few kilopascals are combined into ropes via microfluidic twisting. This is demonstrated for recently introduced fibers made of bicontinuous interfacially jammed emulsion gels (bijels). Bijels show promising applications in use as membranes, microreactors, energy and healthcare materials, but their low tensile strength make reinforcement strategies imperative. Hydrodynamic twisting allows to produce continuous …
Bicontinuous Interfacially Jammed Emulsion Gels (Bijels) As Media For Enabling Enzymatic Reactive Separation Of A Highly Water Insoluble Substrate, Sanghak Cha, Hyun Lim, Martin Haase, Kathleen Stebe, Gyoo Jung, Daeyeon Lee
Bicontinuous Interfacially Jammed Emulsion Gels (Bijels) As Media For Enabling Enzymatic Reactive Separation Of A Highly Water Insoluble Substrate, Sanghak Cha, Hyun Lim, Martin Haase, Kathleen Stebe, Gyoo Jung, Daeyeon Lee
Henry M. Rowan College of Engineering Faculty Scholarship
Although enzymes are efficient catalysts capable of converting various substrates into desired products with high specificity under mild conditions, their effectiveness as catalysts is substantially reduced when substrates are poorly water-soluble. In this study, to expedite the enzymatic conversion of a hydrophobic substrate, we use a bicontinuous interfacially jammed emulsion gel (bijel) which provides large interfacial area between two immiscible liquids: oil and water. Using lipase-catalyzed hydrolysis of tributyrin as a model reaction in a batch mode, we show that bijels can be used as media to enable enzymatic reaction. The bijel system gives a four-fold increase in the initial …
Integrating The Three E’S In Wastewater Treatment, Kirti Maheshkumar Yenkie
Integrating The Three E’S In Wastewater Treatment, Kirti Maheshkumar Yenkie
Henry M. Rowan College of Engineering Faculty Scholarship
Water is often the most mispriced and misused component in domestic, industrial and agricultural sectors. The rise in world population and industrialization in developing nations has tremendously increased the demand for water and has resulted in the generation of wastewater which is contaminated with dangerous pollutants and unknown contaminants. Furthermore, if the wastewater is not treated properly the toxic pollutants will leach back into the ground ultimately contaminating the groundwater resources. Thus, wastewater treatment, reuse, and safe disposal have become crucial for sustainable existence. In this review, the different aspects involved in designing efficient and sustainable wastewater treatment systems such …
Tracking Lysosome Migration Within Chinese Hamster Ovary (Cho) Cells Following Exposure To Nanosecond Pulsed Electric Fields, Gary L. Thompson Iii, Hope T. Beier, Bennett L. Ibey
Tracking Lysosome Migration Within Chinese Hamster Ovary (Cho) Cells Following Exposure To Nanosecond Pulsed Electric Fields, Gary L. Thompson Iii, Hope T. Beier, Bennett L. Ibey
Henry M. Rowan College of Engineering Faculty Scholarship
Above a threshold electric field strength, 600 ns-duration pulsed electric field (nsPEF) exposure substantially porates and permeabilizes cellular plasma membranes in aqueous solution to many small ions. Repetitive exposures increase permeabilization to calcium ions (Ca2+) in a dosage-dependent manner. Such exposure conditions can create relatively long-lived pores that reseal after passive lateral diffusion of lipids should have closed the pores. One explanation for eventual pore resealing is active membrane repair, and an ubiquitous repair mechanism in mammalian cells is lysosome exocytosis. A previous study shows that intracellular lysosome movement halts upon a 16.2 kV/cm, 600-ns PEF exposure of …
Synthesis And Analysis Of Separation Processes For Extracellular Chemicals Generated From Microbial Conversions, Wenzhao Wu, Kirti Maheshkumar Yenkie, Christos T. Maravelias
Synthesis And Analysis Of Separation Processes For Extracellular Chemicals Generated From Microbial Conversions, Wenzhao Wu, Kirti Maheshkumar Yenkie, Christos T. Maravelias
Henry M. Rowan College of Engineering Faculty Scholarship
Recent advances in metabolic engineering have enabled the production of chemicals via bio-conversion using microbes. However, downstream separation accounts for 60–80% of the total production cost in many cases. Previous work on microbial production of extracellular chemicals has been mainly restricted to microbiology, biochemistry, metabolomics, or techno-economic analysis for specific product examples such as succinic acid, xanthan gum, lycopene, etc. In these studies, microbial production and separation technologies were selected apriori without considering any competing alternatives. However, technology selection in downstream separation and purification processes can have a major impact on the overall costs, product recovery, and purity. To this …
One-Pot Aqueous And Template-Free Synthesis Of Mesoporous Polymeric Resins, Mahboubeh Nabavinia, Baishali Kanjilal, Alexander Hesketh, Philip Wall, Alireza Shirazi Amin, Peter Kerns, Joseph F. Stanzione Iii, Steven Suib, Fujian Lu, Iman Noshadi
One-Pot Aqueous And Template-Free Synthesis Of Mesoporous Polymeric Resins, Mahboubeh Nabavinia, Baishali Kanjilal, Alexander Hesketh, Philip Wall, Alireza Shirazi Amin, Peter Kerns, Joseph F. Stanzione Iii, Steven Suib, Fujian Lu, Iman Noshadi
Henry M. Rowan College of Engineering Faculty Scholarship
This work explores the novel one-pot aqueous phase synthesis of mesoporous phenolic-hyperbranched polyethyleneimine resins without the use of a template, and their utility as heterogeneous catalysts in batch reactors and continuous microreactors. Catalyst surface areas of up to 432 m2/g were achieved with a uniform Pd distribution and an interconnected, highly porous, network structure, confirmed through Brunauer–Emmett–Teller (BET) surface area measurements, scanning electron microscopes (SEM), X-Ray Photoelectron Spectroscopy (XPS), Transmission Electron Microscopy (TEM), and Energy-dispersive X-ray spectroscopy (EDS). The heterogeneous catalysts achieved a maximum 98.98 ± 1% conversion in batch Suzuki couplings, with conversions being dependent upon reaction …
Methods For Estimating Supersaturation In Antisolvent Crystallization Systems, Jennifer M. Schall, Gerard Capellades, Allan S. Myerson
Methods For Estimating Supersaturation In Antisolvent Crystallization Systems, Jennifer M. Schall, Gerard Capellades, Allan S. Myerson
Henry M. Rowan College of Engineering Faculty Scholarship
The mole fraction and activity coefficient-dependent (MFAD) supersaturation expression is the least-assumptive, practical choice for calculating supersaturation in solvent mixtures. This paper reviews the basic thermodynamic derivation of the supersaturation expression, revisits common simplifying assumptions, and discusses the shortcomings of those assumptions for the design of industrial crystallization processes. A step-by-step methodology for estimating the activity-dependent supersaturation is provided with focus on ternary systems. This method requires only solubility data and thermal property data from a single differential scanning calorimetry (DSC) experiment. Two case studies are presented, where common simplifications to the MFAD supersaturation expression are evaluated: (1) for various …
Incorporating Solvent-Dependent Kinetics To Design A Multistage, Continuous, Combined Cooling/Antisolvent Crystallization Process, Jennifer M. Schall, Gerard Capellades, Jasdeep S. Mandur, Richard D. Braatz, Allan S. Myerson
Incorporating Solvent-Dependent Kinetics To Design A Multistage, Continuous, Combined Cooling/Antisolvent Crystallization Process, Jennifer M. Schall, Gerard Capellades, Jasdeep S. Mandur, Richard D. Braatz, Allan S. Myerson
Henry M. Rowan College of Engineering Faculty Scholarship
Combined cooling and antisolvent crystallization enables crystallization of many pharmaceutical products, but its process design typically neglects solvent composition influences on crystallization kinetics. This paper evaluates the influence of solvent-dependent nucleation and growth kinetics on the design of optimal, multistage mixed-suspension, mixed-product removal (MSMPR) crystallization cascades. The ability to independently select temperature and solvent compositions in each stage of the cascade serves to greatly expand the attainable region for a two-stage cascade, with diminishing returns for additional stages. Failure to include solvent-dependent kinetics can result in simulating incorrect attainable regions, active pharmaceutical ingredient (API) yields, and crystal size distributions. This …