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Controlling Nonspecific Adsorption Of Proteins At Bio-Interfaces For Biosensor And Biomedical Applications, Harshil D. Dhruv
Controlling Nonspecific Adsorption Of Proteins At Bio-Interfaces For Biosensor And Biomedical Applications, Harshil D. Dhruv
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
Partitioning of poly(ethyleneglycol) (PEG) molecules in 2-D and 3-D systems is presented as a self-assembly approach for controlling non-specific adsorption of proteins at interfaces.
Lateral restructuring of multi-component Langmuir monolayers to accommodate adsorbing proteins was investigated as a model 2-D system. Ferritin adsorption to monolayers containing cationic, nonionic, and PEG bearing phospholipids induced protein sized binding pockets surrounded by PEG rich regions. The number, size, and distribution of protein imprint sites were controlled by the molar ratios, miscibility, and lateral mobility of the lipids.
The influence of PEG chain length on the ternary monolayer restructuring and protein distribution was also …