Engineering Commons^™

Development Of The Assessment Of Clinical Prediction Model Transportability (Apt) Checklist, Sean Chonghwan Yu

McKelvey School of Engineering Theses & Dissertations

Clinical Prediction Models (CPM) have long been used for Clinical Decision Support (CDS) initially based on simple clinical scoring systems, and increasingly based on complex machine learning models relying on large-scale Electronic Health Record (EHR) data. External implementation – or the application of CPMs on sites where it was not originally developed – is valuable as it reduces the need for redundant de novo CPM development, enables CPM usage by low resource organizations, facilitates external validation studies, and encourages collaborative development of CPMs. Further, adoption of externally developed CPMs has been facilitated by ongoing interoperability efforts in standards, policy, and …

A Neuromorphic Machine Learning Framework Based On The Growth Transform Dynamical System, Ahana Gangopadhyay

McKelvey School of Engineering Theses & Dissertations

As computation increasingly moves from the cloud to the source of data collection, there is a growing demand for specialized machine learning algorithms that can perform learning and inference at the edge in energy and resource-constrained environments. In this regard, we can take inspiration from small biological systems like insect brains that exhibit high energy-efficiency within a small form-factor, and show superior cognitive performance using fewer, coarser neural operations (action potentials or spikes) than the high-precision floating-point operations used in deep learning platforms. Attempts at bridging this gap using neuromorphic hardware has produced silicon brains that are orders of magnitude …

Improving Additional Adversarial Robustness For Classification, Michael Guo

McKelvey School of Engineering Theses & Dissertations

Although neural networks have achieved remarkable success on classification, adversarial robustness is still a significant concern. There are now a series of approaches for designing adversarial examples and methods to defending against them. This paper consists of two projects. In our first work, we propose an approach by leveraging cognitive salience to enhance additional robustness on top of these methods. Specifically, for image classification, we split an image into the foreground (salient region) and background (the rest) and allow significantly larger adversarial perturbations in the background to produce stronger attacks. Furthermore, we show that adversarial training with dual-perturbation attacks yield …

Predicting Disease Progression Using Deep Recurrent Neural Networks And Longitudinal Electronic Health Record Data, Seunghwan Kim

McKelvey School of Engineering Theses & Dissertations

Electronic Health Records (EHR) are widely adopted and used throughout healthcare systems and are able to collect and store longitudinal information data that can be used to describe patient phenotypes. From the underlying data structures used in the EHR, discrete data can be extracted and analyzed to improve patient care and outcomes via tasks such as risk stratification and prospective disease management. Temporality in EHR is innately present given the nature of these data, however, and traditional classification models are limited in this context by the cross- sectional nature of training and prediction processes. Finding temporal patterns in EHR is …

Predicting Disease Progression Using Deep Recurrent Neural Networks And Longitudinal Electronic Health Record Data, Seunghwan Kim

McKelvey School of Engineering Theses & Dissertations

Electronic Health Records (EHR) are widely adopted and used throughout healthcare systems and are able to collect and store longitudinal information data that can be used to describe patient phenotypes. From the underlying data structures used in the EHR, discrete data can be extracted and analyzed to improve patient care and outcomes via tasks such as risk stratification and prospective disease management. Temporality in EHR is innately present given the nature of these data, however, and traditional classification models are limited in this context by the cross-sectional nature of training and prediction processes. Finding temporal patterns in EHR is especially …

Differential Estimation Of Audiograms Using Gaussian Process Active Model Selection, Trevor Larsen

McKelvey School of Engineering Theses & Dissertations

Classical methods for psychometric function estimation either require excessive resources to perform, as in the method of constants, or produce only a low resolution approximation of the target psychometric function, as in adaptive staircase or up-down procedures. This thesis makes two primary contributions to the estimation of the audiogram, a clinically relevant psychometric function estimated by querying a patient’s for audibility of a collection of tones. First, it covers the implementation of a Gaussian process model for learning an audiogram using another audiogram as a prior belief to speed up the learning procedure. Second, it implements a use case of …

An Improved Algorithm For Learning To Perform Exception-Tolerant Abduction, Mengxue Zhang

McKelvey School of Engineering Theses & Dissertations

Abstract

Inference from an observed or hypothesized condition to a plausible cause or explanation for this condition is known as abduction. For many tasks, the acquisition of the necessary knowledge by machine learning has been widely found to be highly effective. However, the semantics of learned knowledge are weaker than the usual classical semantics, and this necessitates new formulations of many tasks. We focus on a recently introduced formulation of the abductive inference task that is thus adapted to the semantics of machine learning. A key problem is that we cannot expect that our causes or explanations will be perfect, …

Indoor Scene Localization To Fight Sex Trafficking In Hotels, Abigail Stylianou

McKelvey School of Engineering Theses & Dissertations

Images are key to fighting sex trafficking. They are: (a) used to advertise for sex services,(b) shared among criminal networks, and (c) connect a person in an image to the place where the image was taken. This work explores the ability to link images to indoor places in order to support the investigation and prosecution of sex trafficking. We propose and develop a framework that includes a database of open-source information available on the Internet, a crowd-sourcing approach to gathering additional images, and explore a variety of matching approaches based both on hand-tuned features such as SIFT and learned features …

Applying Bayesian Machine Learning Methods To Theoretical Surface Science, Shane Carr

McKelvey School of Engineering Theses & Dissertations

Machine learning is a rapidly evolving field in computer science with increasingly many applications to other domains. In this thesis, I present a Bayesian machine learning approach to solving a problem in theoretical surface science: calculating the preferred active site on a catalyst surface for a given adsorbate molecule. I formulate the problem as a low-dimensional objective function. I show how the objective function can be approximated into a certain confidence interval using just one iteration of the self-consistent field (SCF) loop in density functional theory (DFT). I then use Bayesian optimization to perform a global search for the solution. …