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Connexin Overexpression Differentially Suppresses Glioma Growth And Contributes To The Bystander Effect Following Hsv-Thymidine Kinase Gene Therapy, T. Jiminez, W. Fox, C. Naus, J. Galipeau, Daniel Belliveau
Connexin Overexpression Differentially Suppresses Glioma Growth And Contributes To The Bystander Effect Following Hsv-Thymidine Kinase Gene Therapy, T. Jiminez, W. Fox, C. Naus, J. Galipeau, Daniel Belliveau
Daniel J. Belliveau
Neoplastic transformation is frequently associated with a loss of gap junctional intercellular communication and reduced expression of connexins. The introduction of connexin genes into tumor cells reverses the proliferative characteristics of such cells. However, there is very little comparative information on the effects of different connexins on cancer cell growth. We hypothesized that Cx26, Cx32, or Cx43 would display differential growth suppression of C6 glioma cells and uniquely modulate the bystander effect following transduction of C6 cells with HSVtk followed by suicide gene therapy. The bystander phenomenon is the death of a greater number of tumor cells than are expressing …
Enhanced Neurite Outgrowth In Pc12 Cells Mediated By Connexin Hemichannels And Atp, Daniel Belliveau, M. Bani-Yagoub, R. Mcgirr, C. Naus, W. Rushlow
Enhanced Neurite Outgrowth In Pc12 Cells Mediated By Connexin Hemichannels And Atp, Daniel Belliveau, M. Bani-Yagoub, R. Mcgirr, C. Naus, W. Rushlow
Daniel J. Belliveau
Gap junctions have traditionally been described as transmembrane channels that facilitate intercellular communication via the passage of small molecules. Connexins, the basic building blocks of gap junctions, are expressed in most mammalian tissues including the developing and adult central nervous system. During brain development, connexins are temporally and spatially regulated suggesting they play an important role in the proper formation of the central nervous system. In the current study, connexins 32 and 43 were overexpressed in PC12 cells to determine whether connexins are involved in neuronal differentiation. Both connexin 32 and 43 were appropriately trafficked to the cell membrane following …