Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Education
Neural Correlates Of Interval Timing Deficits In Schizophrenia, Ariel W. Snowden, Catalin V. Buhusi
Neural Correlates Of Interval Timing Deficits In Schizophrenia, Ariel W. Snowden, Catalin V. Buhusi
Psychology Faculty Publications
Previous research has shown that schizophrenia (SZ) patients exhibit impairments in interval timing. The cause of timing impairments in SZ remains unknown but may be explained by a dysfunction in the fronto-striatal circuits. Although the current literature includes extensive behavioral data on timing impairments, there is limited focus on the neural correlates of timing in SZ. The neuroimaging literature included in the current review reports hypoactivation in the dorsal-lateral prefrontal cortex (DLPFC), supplementary motor area (SMA) and the basal ganglia (BG). Timing deficits and deficits in attention and working memory (WM) in SZ are likely due to a dysfunction of …
Impaired Latent Inhibition In Gdnf-Deficient Mice Exposed To Chronic Stress, Mona Buhusi, Colten K. Brown, Catalin V. Buhusi
Impaired Latent Inhibition In Gdnf-Deficient Mice Exposed To Chronic Stress, Mona Buhusi, Colten K. Brown, Catalin V. Buhusi
Psychology Faculty Publications
Increased reactivity to stress is maladaptive and linked to abnormal behaviors and psychopathology. Chronic unpredictable stress (CUS) alters catecholaminergic neurotransmission and remodels neuronal circuits involved in learning, attention and decision making. Glial-derived neurotrophic factor (GDNF) is essential for the physiology and survival of dopaminergic neurons in substantia nigra and of noradrenergic neurons in the locus coeruleus. Up-regulation of GDNF expression during stress is linked to resilience; on the other hand, the inability to up-regulate GDNF in response to stress, as a result of either genetic or epigenetic modifications, induces behavioral alterations. For example, GDNF-deficient mice exposed to chronic stress exhibit …