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Impaired Latent Inhibition In Gdnf-Deficient Mice Exposed To Chronic Stress, Mona Buhusi, Colten K. Brown, Catalin V. Buhusi
Impaired Latent Inhibition In Gdnf-Deficient Mice Exposed To Chronic Stress, Mona Buhusi, Colten K. Brown, Catalin V. Buhusi
Psychology Faculty Publications
Increased reactivity to stress is maladaptive and linked to abnormal behaviors and psychopathology. Chronic unpredictable stress (CUS) alters catecholaminergic neurotransmission and remodels neuronal circuits involved in learning, attention and decision making. Glial-derived neurotrophic factor (GDNF) is essential for the physiology and survival of dopaminergic neurons in substantia nigra and of noradrenergic neurons in the locus coeruleus. Up-regulation of GDNF expression during stress is linked to resilience; on the other hand, the inability to up-regulate GDNF in response to stress, as a result of either genetic or epigenetic modifications, induces behavioral alterations. For example, GDNF-deficient mice exposed to chronic stress exhibit …
Stress-Induced Executive Dysfunction In Gdnf-Deficient Mice, A Mouse Model Of Parkinsonism, Mona Buhusi, Kaitlin Olsen, Benjamin Z. Young, Catalin V. Buhusi
Stress-Induced Executive Dysfunction In Gdnf-Deficient Mice, A Mouse Model Of Parkinsonism, Mona Buhusi, Kaitlin Olsen, Benjamin Z. Young, Catalin V. Buhusi
Psychology Faculty Publications
Maladaptive reactivity to stress is linked to improper decision making, impulsivity, and discounting of delayed rewards. Chronic unpredictable stress alters dopaminergic function and re-shapes dopaminergic circuits in key areas involved in decision making, and impairs prefrontal-cortex dependent response inhibition and working memory. Glial-derived neurotrophic factor (GDNF) is essential for regulating dopamine release in the basal ganglia and the survival of dopaminergic neurons, and GDNF-deficient mice are considered an animal model for aging-related Parkinsonism. Recently, GDNF expression in the striatum has been linked to resilience to stress. Here we investigated the effects of chronic unpredictable stress on decision making in GDNF-heterozygous …