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Dissociation Of The Role Of The Prelimbic Cortex In Interval Timing And Resource Allocation: Beneficial Effect Of Norepinephrine And Dopamine Reuptake Inhibitor Nomifensine On Anxiety-Inducing Distraction, Alexander R. Matthews, Olivia H. He, Mona Buhusi, Catalin V. Buhusi

Psychology Faculty Publications

Emotional distracters impair cognitive function. Emotional processing is dysregulated in affective disorders such as depression, phobias, schizophrenia, and PTSD. Among the processes impaired by emotional distracters, and whose dysregulation is documented in affective disorders, is the ability to time in the seconds-to-minutes range, i.e. interval timing. Presentation of task-irrelevant distracters during a timing task results in a delay in responding suggesting a failure to maintain subjective time in working memory, possibly due to attentional and working memory resources being diverted away from timing, as proposed by the Relative Time-Sharing model. We investigated the role of the prelimbic cortex in the …