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1994

Nutrition

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Experimental Induction Of Hepatic Lipidosis In Cats, V Biourge, J Groff, R Munn, Claudia Kirk, T Nyland, V Madeiros, J Morris, Q Rogers Aug 1994

Experimental Induction Of Hepatic Lipidosis In Cats, V Biourge, J Groff, R Munn, Claudia Kirk, T Nyland, V Madeiros, J Morris, Q Rogers

Claudia A Kirk

The effect of long-term voluntary fasting on hematologic variables, biochemical profiles, and liver histologic findings was assessed in 15 obese cats (> 40% overweight). Clinical signs and laboratory results consistent with hepatic lipidosis were observed in 12 of 15 cats after 5 to 7 weeks of fasting, and were associated with 30 to 35% reduction of initial body weight. Histologic examination of successive liver biopsy specimens revealed that obesity was not associated with liver parenchymal lipid accumulation, but that fasting resulted in lipidosis in all 15 cats. The long-term fast was associated with an early (after 2 to 4 weeks of ...