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Medicine and Health Sciences

2008

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Student Research Conference Select Presentations

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38th Annual Wku Student Research Conference, Student Research Council, Western Kentucky University Apr 2008

38th Annual Wku Student Research Conference, Student Research Council, Western Kentucky University

Student Research Conference Select Presentations

Western Kentucky University 38th Annual Student Research Conference program and student abstracts. Saturday, April 12, 2008, Carroll Knicely Conference Center, Bowling Green, Kentucky.


Searching For Binding Partners For The Novel Phkg1 Variant, Phkγ 181, Kishore Polireddy Apr 2008

Searching For Binding Partners For The Novel Phkg1 Variant, Phkγ 181, Kishore Polireddy

Student Research Conference Select Presentations

Phopshorylase kinase (PhK) is a hexadecameric holoenzyme made up of four different subunits in the arrangement (αβγδ)4 and has total molecular mass of 1.3MDa. Alpha and β are regulatory subunits, γ is catalytic, and δ is an intrinsic molecule of calmodulin. PhK is a serine threonine kinase with glycogenolytic regulatory functions. Our lab has recently discovered that the γ subunit can be alternatively processed to produce a truncated form of 181 residues (γ-181). This variant of γ contains a phosphorylation site for PK-C, and its activity is influenced by this phosphorylation. We are using a LexA based yeast ...