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Autophagy Is Stimulated By Acute High Intensity Interval Exercise In Human Skeletal Muscle And Electrical Pulse Stimulation In C2c12 Myotubes In Vitro, Kurt A. Escobar
Autophagy Is Stimulated By Acute High Intensity Interval Exercise In Human Skeletal Muscle And Electrical Pulse Stimulation In C2c12 Myotubes In Vitro, Kurt A. Escobar
Health, Exercise, and Sports Sciences ETDs
Purpose: 1) To compare the effects of an acute bout of HIIT exercise (treadmill running) on autophagy to MICT exercise in human skeletal muscle 3 hours post exercise, and 2) to test an in vitro model of muscle contraction-induced autophagy using electrical pulse stimulation in C2C12 myotubes. Methods: Study 1: Ten recreationally active males and females completed a bout of high intensity interval training (HIIT) exercise and moderate intensity continuous exercise (MICT) exercise in a fasted state. Muscle biopsies from the vastus lateralis were taken pre and 3 hours post-exercise. Muscle tissue was analyzed for protein expression of markers of …