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Behavioral Thermoregulation And Thermal Mismatches Influence Disease Dynamics In Amphibians, Erin Louise Sauer
Behavioral Thermoregulation And Thermal Mismatches Influence Disease Dynamics In Amphibians, Erin Louise Sauer
USF Tampa Graduate Theses and Dissertations
Amphibians are currently the most threatened vertebra taxa on the planet. Hundreds of species are thought to have gone extinct while thousands more have been listed as threatened or endangered over the past few decades. Habitat loss, invasive species, climate change, and disease are all thought to have partially contributed to these declines. Two pathogens in particular, infectious viruses in the genus Ranavirus (simply referred to as ranavirus) and the fungus Batrachochytrium dendrobatidis (Bd), have been associated with global mass mortality events of amphibians. Virulent pathogens such as these tend to impose strong selective pressures on their hosts driving the …
Analyzing The Effects Of Ca2+ Dynamics On Mitochondrial Function In Health And Disease, Patrick Toglia
Analyzing The Effects Of Ca2+ Dynamics On Mitochondrial Function In Health And Disease, Patrick Toglia
USF Tampa Graduate Theses and Dissertations
Mitochondria plays a crucial role in cells by maintaining energy metabolism and directing cell death mechanisms by buffering calcium (Ca2+ )from cytosol. Therefore, the Ca2+ overload of mitochondria due to the upregulated cytosolic Ca2+ , observed in many neurological disorders is hypothesized to be a key pathway leading to mitochondrial dysfunction and cell death. In particular, Ca2+ homeostasis disruptions due to Alzheimer’ s disease (AD)-causing presenilins (PS1/PS2) and oligomeric forms of β-amyloid peptides Aβ commonly found in AD patients are presumed to cause detrimental effects on the mitochondria and its ability to function properly. We begin …