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Viral Shedding And Biodistribution Of G207, A Multimutated, Conditionally Replicating Herpes Simplex Virus Type 1, After Intracerebral Inoculation In Aotus, T. Todo, F. Feigenbaum, S. Rabkin, F. Lakeman, J. Newsome, P. Johnson, E. Mitchell, Daniel Belliveau, J. Ostrove, R. Martuza
Viral Shedding And Biodistribution Of G207, A Multimutated, Conditionally Replicating Herpes Simplex Virus Type 1, After Intracerebral Inoculation In Aotus, T. Todo, F. Feigenbaum, S. Rabkin, F. Lakeman, J. Newsome, P. Johnson, E. Mitchell, Daniel Belliveau, J. Ostrove, R. Martuza
Daniel J. Belliveau
G207 is a multimutated, conditionally replicating herpes simplex virus type 1 (HSV-1) that is currently in clinical trial for patients with malignant glioma. G207 exhibits an efficient oncolytic activity in tumor cells, yet minimal toxicity in normal tissue when injected into the brains of HSV-susceptible mice or nonhuman primates. In this study, we evaluated the shedding and biodistribution of clinical-grade G207 after intracerebral inoculation (3 × 107 pfu) in four New World owl monkeys (Aotus nancymae). Using PCR analyses and viral cultures, neither infectious virus nor viral DNA was detected from tear, saliva, or vaginal secretion samples at any time …