History Commons^™

Oncolog, Volume 59, Number 11-12, November-December 2014, Bryan Tutt, Sunita Patterson, S. Moreau

OncoLog MD Anderson's Report to Physicians (All issues)

• Striving to Improve Treatments for Uveal Melanoma: Although primary uveal melanoma can be effectively treated with radiation or surgery, patients with metastatic disease-or those at high risk for metastases-have few proven options. But specialists in medical oncology, radiation oncology, ophthalmology, surgery, and traditional research are working to improve those options
• Beyond Diabetes: Metformin May Have Broad Utility in Cancer: Metformin, an inexpensive drug that has been prescribed for diabetes for decades, may also be useful in preventing or treating several types of cancer
• HOUSE CALL: Smoking Cessation-Medications help smokers quit
• INBRIEF: Vaccine Explored to Reduce Risk of HER2-Positive Breast Cancer …

Robert Edward Gross (1905-1988): Ligation Of A Patent Ductus Arteriosus And The Birth Of A Specialty., Alexander V. Chalphin, Bs, Charles J. Yeo, Md, Scott W. Cowan, Md, Stacey Milan, Md

Department of Surgery Gibbon Society Historical Profiles

The early 20th century saw an explosion in surgical expertise. Specialties dedicated to delicate organs such as the heart and vulnerable populations, like children, were in their infancy. Dr. William E. Ladd, the father of pediatric surgery, founded the first dedicated department of pediatric surgery at Boston Children’s Hospital in 1910. At the time, attempts at cardiac surgery almost universally ended in death of the patient. The first successful surgical treatment of the cardiac valves would not occur for another 15 years, and the great vessels would remain out of reach for decades more. Dr. Robert E. Gross, the shy …

Jewish Dermatologists In Nazi Germany., Walter H.C. Burgdorf, Lawrence Charles Parish

Department of Dermatology and Cutaneous Biology Faculty Papers

With the development of medical specialties beginning in the 1860’s, physicians could devote their time to the study of specific organ systems or surgical approaches. Although Jews had been given full rights in the new Germany by 1871, prejudice and other restrictions often precluded hospital and university appointments. Major specialities like internal medicine and surgery were almost closed to Jews, as were obstetrics and gynecology. Dermatology with its heavy emphasis on sexually transmitted diseases evolved into a suitable domain for Jewish physicians almost by default. Even those Jews who converted to Christianity were not spared from discrimination. Paul Gerson Unna …

“In Light Of Real Alternatives”: Negotiations Of Fertility And Motherhood In Morocco And Oman, Victoria E. Mohr

Student Publications

Many states in the Arab world have undertaken wide-ranging family planning polices in the last two decades in an effort to curb high fertility rates. Oman and Morocco are two such countries, and their policies have had significantly different results. Morocco experienced a swift drop in fertility rates, whereas Oman’s fertility has declined much more slowly over several decades. Many point to the more conservative religious and cultural context of Oman for their high fertility rates, however economics and the state of biomedical health care often present a more compelling argument for the distinct differences between Omani and Moroccan family …

Oncolog, Volume 59, Number 10, October 2014, Sarah Bronson, Kathryn L. Hale, Roberto Molar-Candanosa, K. Stuyck

OncoLog MD Anderson's Report to Physicians (All issues)

• New Drugs for Myeloproliferative Neoplasms Ease Suffering and Extend Life: A new class of drugs has redefined treatment for patients with myeloproliferative neoplasms by easing their symptom burden while extending their lives
• Neoadjuvant Targeted Therapy May Offer Multiple Benefits for Patients with Locally Advanced Renal Cancer: Despite definitive treatment with nephrectomy, locally advanced renal cancer recurs in 20%-30% of patients, substantially reducing their chance for long-term survival. To prevent such recurrences and prolong survival, urologic oncologists are studying the integration of targeted molecular therapies with surgical treatments
• New Combination Therapy Offers Potential to Cure FLT3-ITD Acute Myelogenous Leukemia: A new …

Oncolog, Volume 59, Number 09, September 2014, Stephanie Deming, Bryan Tutt, Joe Munch, Jill Deisigne

OncoLog MD Anderson's Report to Physicians (All issues)

• Biomarker-Driven Clinical Trials may Improve Personalized Treatment for Patients With Lung Cancer: Innovative clinical trials that assign patients to treatment arms based on tumor biomarkers could lead to increase treatment options for patients with lung cancer
• New Antibody-Chemotherapy Combinations Show Promise Against Acute Lymphoblastic Leukemia: Two investigational agents-inotuzumab and ofatumumab-shows promise when combined with cytotoxic chemotherapy drugs for the treatment of acute lymphoblastic leukemia (ALL) in adults
• Deep Inspiration Breath Hold Protects Against Radiation-Induced Cardiotoxicity in Patients With Left-Sided Breast cancers: Patients with lest-sided breast cancers have an increased risk of heart damage from adjuvant radiation therapy given after lumpectomy …

Carmen Pettapiece, D.O. Scrapbook 2, Carmen Pettapiece D.O.

Carmen Pettapiece, D.O. Scrapbooks

Scrapbook of personal papers and osteopathy-related materials from the collection of Carmen Pettapiece, D.O.

Oncolog, Volume 59, Number 08, August 2014, Kathryn L. Hale, Bryan Tutt, Sunita Patterson, R. Molar-Candanosa

OncoLog MD Anderson's Report to Physicians (All issues)

• Immune Checkpoint Inhibitors Show Promise Against Metastatic Renal Cell Carcinoma, Other Difficult-to-Treat Cancers: A decade ago, oncologists had little to offer most patients with metastatic renal cell carcinoma (RCC). However, a breakthrough discovery that has already changed the treatment of metastatic melanoma is showing promise against other metastatic cancers-including metastatic RCC-and giving patients new hope for long-term survival
• Clinical Study Offers Definitive Local Treatment of Bone Metastases from Breast Cancer: Metastatic breast cancer carries a poor prognosis, and most systemic treatments for metastatic disease aim to slow its progression rather than to cure it. In a select group of patients, …

Infectious Diseases, Bert Chapman

Libraries Faculty and Staff Scholarship and Research

Provides information about the role of infectious diseases in the early years of U.S. History, with particular emphasis on how they impacted injuries sustained in military conflict.

Oncolog, Volume 59, Number 07, July 2014, Sarah Bronson, Joe Munch, Bryan Tutt, K. Stuyck

OncoLog MD Anderson's Report to Physicians (All issues)

• Side Effects of Targeted Molecular Agents Vary According to Mechanism of Action: The main side effects of cytotoxic chemotherapy are notorious. But the side effects of newer, targeted molecular agents are less well known, so patients receiving such drugs may not know what to expect and may require additional guidance from physicians
• INBRIEF: Study Finds Less Frequent Bisphosphonate Treatment Equivalent to Standard Regimen
• RAS Mutation Status May predict Outcomes After Surgery for Colorectal Cancer Liver Metastases
• HPV Test Does Not Replace Pap Test for Cervical cancer Screening: The recent approval of a human papillomavirus (HPV) test for cervical cancer screening …

Oncolog, Volume 59, Number 06, June 2014, Jill Deisigne, Luanne Jorewicz, K. Stuyck

OncoLog MD Anderson's Report to Physicians (All issues)

• New Agents Hold Promise for Patients With Advanced Thyroid Cancer: New agents are expanding treatment options for patients with advanced thyroid cancer-not only the papillary variant but also the less common medullary and differentiated variants of the disease
• Surgical Options for Lymphedema: Lymphedema of the extremities, whether from cancer treatment or other causes, typically is not curable. But advances in surgical techniques are reducing or eliminating symptoms for many patients
• INBRIEF: Intensity-Modulated Radiation Therapy Improves Survival in Head and Neck Cancer Patients/ Research Findings Could Lead to Blood Test for Cancer-Related Gene Defects/ Tumor-Suppressing Protein May Help Predict Survival in …

Francis F. Maury, M.D. (1840 To 1879): An Often Forgotten Pioneer In Early American Surgery., Guillaume S. Chevrollier, B.S., Scott W. Cowan, Md, Charles J. Yeo, Md, John C. Kairys, Md

Department of Surgery Gibbon Society Historical Profiles

Francis F. Maury (Fig. 1) was born on August 9, 1840, in Danville, Kentucky, where he was raised on a farm by his mother and father. His father was an Episcopal clergyman of Huguenot descent, whose forefathers had fled from France to escape religious persecution. After receiving a Bachelor of Arts degree from Center College in the summer of 1860, he entered medical school at the University of Virginia. After one full term, he matriculated to Philadelphia’s Jefferson Medical College and completed his medical education as a private student under the direction of Dr. Samuel D. Gross.1, 2 He obtained …

Ambroise Paré (1510 To 1590): A Surgeon Centuries Ahead Of His Time., James T. Shen, B.S., Michael Weinstein, Md, Alec C. Beekley, Md, Charles J. Yeo, Md, Scott W. Cowan, Md

Department of Surgery Gibbon Society Historical Profiles

In their extensive writings, Hippocrates and Celsus counseled physicians to be knowledgeable in both the medical and surgical management of patient recovery. However, their words fell by the wayside because cutting of the body was forbidden by the Roman Catholic Church. Furthermore, the contemporaneous Arabic medical teachings emphasized tradition and authority over observation and personal experience. This created an ever-growing rift between the schools of surgical and pharmacologic medicine with both groups denying their involvement in the other domain. Surgeons had been plagued by postoperative complications including infection, malnutrition, and muscular wasting for centuries. Surgeons were forced to re-examine how …

Wai-Kwan Alfred Yung, Md, Oral History Interview, May 7, 2014, Wai-Kwan Alfred Yung Md, Tacey A. Rosolowski Phd

Interview Sessions

Major Topics Coveted:

• History of Neuro-Oncology services and research at MD Anderson
• History of the Department of Neuro-Oncology
• The Brain Tumor Center: collaborative relationships and shared resources with Neuro-Oncology, Neuro-Surgery, Neuro-Pathology, neuro-imaging and other support fields

Roscoe Reid Graham (1890 To 1948): A Canadian Pioneer In General Surgery., Christine C. Piper, Ba, Charles J. Yeo, Md, Scott W. Cowan, Md

Department of Surgery Gibbon Society Historical Profiles

Roscoe Reid Graham, a Canadian surgeon trained at the University of Toronto, was a true pioneer in the field of general surgery. Although he may be best known for his omental patch repair of perforated duodenal ulcers-often referred to as the "Graham patch"-he had a number of other significant accomplishments that decorated his surgical career. Dr. Graham is credited with being the first surgeon to successfully enucleate an insulinoma. He ventured to do an essentially brand new operation based solely on his patient's symptoms and physical findings, a courageous move that even some of the most talented surgeons would shy …

Oncolog, Volume 59, Number 05, May 2014, Bryan Tutt, Therese Bevers, Zach Bohannan

OncoLog MD Anderson's Report to Physicians (All issues)

• New Treatments may Improve Outcomes for AL Amyloidosis Patients: AL amyloidosis-a rare, potentially fatal disease-has no approved treatments. The ''standard'' treatments are prescribed off-label, and few clinical trials have compared their effectiveness
• Dialog: Screening Mammography Reduces Breast Cancer-Related deaths
• 'Sleeping Beauty'' Technique Modifies T Cells to Treat B Cell Malignancies: A novel technique that helps the patient's own immune system find and destroy cancer cells could extend remission times for patients with B cell lymphomas and leukemias
• INBRIEF: Analysis Suggests Need to Revise Low-Grade Glioma Classification, Treatment/Combination of Antiangiogenic Drugs Shows Activity Against Solid Tumors/ Computed Tomography Predicts Chemotherapy Response …

H. Brownell Wheeler Papers, 1961 – 2009: A Finding Aid, Kristine M. Reinhard

Kristine M. Sjostedt

The H. Brownell Wheeler Papers document the early history of the University of Massachusetts Medical School (UMMS) and University Hospital, collectively known as University of Massachusetts Medical Center (UMMC). This collection also chronicles Dr. Wheeler’s career as a vascular surgeon, educator, administrator, end-of-life care advocate, and inventor. Also included in this collection are materials related to Dr. Wheeler’s personal life including his interest in travel and wood sculpting.

Oncolog, Volume 59, Number 04, April 2014, Zach Bohannan, Joe Munch, J. Delsigne

OncoLog MD Anderson's Report to Physicians (All issues)

• New fat Grafting Technique Improves Aesthetic Outcomes Following Head and Neck Reconstructive Surgery: A new gat grafting technique is enabling reconstructive surgeons to maximize aesthetic outcomes following major reconstruction for head and neck cancer treatment-related defects
• INBRIEF: Invasive Bladder Cancer Subtypes Resemble Breast Cancer Subtypes
• New Kinase Inhibitors Hold Promise for Chronic Lymphocytic Leukemia, Other B-Cell Malignancies: New targeted therapies against chronic lymphocytic leukemia (CLL) are eliciting overall response rates similar to those achieved using standard chemoimmunotherapy but with fewer toxic effects
• HOUSE CALL: Animal-Assisted Therapy- Interacting with pets helps recovery

Mary H. Gibbon: Teamwork Of The Heart., Alexandra Columbus, Ba, Scott W. Cowan, Md, Charles J. Yeo, Md, Stacey A. Milan, Md

Department of Surgery Gibbon Society Historical Profiles

Mary "Maly" Hopkinson Gibbon was born on September 25, 1903, to an affluent New England family who encouraged her to embrace her intelligence and to follow that by which she was intrigued. In doing this, Maly pursued work in scientific research, where she ultimately met her first husband, Dr. John ‘‘Jack’’ H. Gibbon. Jack and Maly were partners in every sense of the word. Their collaboration, both within and beyond the walls of the research laboratory, made it possible for the Gibbon dream of the heart–lung machine to be realized.

Oncolog, Volume 59, Number 03, March 2014, Bryan Tutt, Joe Munch, K. Stuyck

OncoLog MD Anderson's Report to Physicians (All issues)

• Expanding the Use of Laparoscopic Liver Resection: Minimally invasive surgical resection of liver tumors once was used only in select patients with easily accessible lesions located in the anterior of the liver. However, recent improvements in surgical techniques and the use of preoperative imaging have made laparoscopic approaches possible for even compels liver resection
• Physicians Refining Lung Cancer Screening Program: Lung cancer screening with low-dose computed tomography (CT) has been shown to reduce the rate of lung cancer-specific mortality in people at high risk for the disease
• Should the Primary Tumor Be Treated in Patients With Metastatic Prostate Cancer?: Researchers …

Oncolog, Volume 59, Number 02, February 2014, Sarah Bronson, Kathryn L. Hale, Bryan Tutt, M. Yeoman

OncoLog MD Anderson's Report to Physicians (All issues)

• New Approaches Revolutionize the Treatment of Advanced Melanoma: Recent breakthroughs in immunotherapy and targeted therapy have improved outcomes for patients with advanced melanoma
• Comprehensive Tobacco Treatment Approach Helps Patients Quit on Their Terms: Kicking a tobacco habit is a formidable task. Quitting tobacco after a diagnosis of cancer, can be even more difficult
• Targeted Drug Shows Promise Against Advanced Breast Cancer: Adding the experimental kinase inhibitor palbociclib to standard hormonal therapy may delay disease progression in patients with advanced breast cancer that is estrogen receptor (ER) positive and human epidermal growth factor receptor 2 (HER@) negative
• HOUSE CALL: Avoiding Food-Drug …

Dr. Seishu Hanaoka (1760-1835): Surgeon, Pharmacist, And Anesthesiologist., Drew L. Kotler, B.A., Hitoshi Hirose, Md, Charles J. Yeo, Md, Scott W. Cowan, Md

Department of Surgery Gibbon Society Historical Profiles

The notion of decreasing pain in surgery stretches back thousands of years with alcohol noted as one of the first anesthetics. Natural elements including coca and opium have been used by various civilizations in an attempt to mute the searing pain of surgery. By the 16th century, physicians around the world began to experiment with nitrous oxide and ether, providing the groundwork for the future of modern anesthesia. The successful application of general anesthesia in surgery was first documented in 1804 by Dr. Seishu Hanaoka (Fig. 1) in Wakayama, Japan, during a breast lumpectomy. During the case, Dr. Hanaoka served …

Oncolog, Volume 59, Number 01, January 2014, Joe Munch, Jill Delsigne, M. Yeoman

OncoLog MD Anderson's Report to Physicians (All issues)

• Addressing Fertility Issues in Cancer Patients: For some newly diagnosed cancer patients, whether they will be able to have children after treatment is the furthest question from their minds-until the risks of therapy bring it front-and-center
• INBRIEF: Intensity-Modulated Proton Therapy May Reduce Side Effects of Oropharyngeal Carcinoma Treatment
• Medical Advances Improve Bile Duct Cancer Treatment: Cholangiocarcinoma, the most common bile duct cancer, is a clinically silent disease in its early stages; patients usually present with advanced disease, which carries a poor prognosis
• HOUSE CALL: Weight Loss Tips for Breast Cancer Survivors-Losing excess weight has multiple benefits