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Full-Text Articles in Arts and Humanities
Structure Of Germline Immunoglobulin Heavy-Chain Gamma 1 Transcripts In Interleukin 4 Treated Mouse Spleen Cells, M. Xu, Janet Stavnezer
Women’s Health Research Faculty Publications
Antibody class switching is mediated by a DNA recombination event that replaces the C mu gene with one of the other heavy (H) chain constant region (CH) genes located 3' to the C mu gene. The regulation of this process is essential to the immune response because different CH regions provide different biological functions. Correlative evidence indicates that the isotype (class) specificity of the switch is determined by the accessibility of specific CH genes as indicated by hypomethylation and transcriptional activity. For example, RNAs transcribed from specific unrearranged CH genes are induced prior to switching under conditions that promote subsequent ...