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Full-Text Articles in Arts and Humanities
The Dopamine B-Hydroxylase 19 Bp Insertion/Deletion Polymorphism Was Associated With First-Episode But Not Medicated Chronic Schizophrenia, Li Hui, Xuan Zhang, Xu-Feng Huang, Mei Han, Francesca Fernandez, Yaqin Yu, Shilong Sun, Wenjun Li, Da Chen, Mei Xiu, Thomas Kosten, Xiang Zhang
The Dopamine B-Hydroxylase 19 Bp Insertion/Deletion Polymorphism Was Associated With First-Episode But Not Medicated Chronic Schizophrenia, Li Hui, Xuan Zhang, Xu-Feng Huang, Mei Han, Francesca Fernandez, Yaqin Yu, Shilong Sun, Wenjun Li, Da Chen, Mei Xiu, Thomas Kosten, Xiang Zhang
Xu-Feng Huang
Background: Numerous studies report dysfunctional dopaminergic and noradrenergic neurotransmission in the pathogenesis of schizophrenia. Dopamine beta-hydroxylase (DBH) is an intracellular enzyme catalyzing the conversion of dopamine to noradrenaline. Functional polymorphisms have been reported in the promoter region of DBH gene, including a 19 bp insertion/deletion polymorphism. The purpose of this study was to investigate whether there was an association between the functional polymorphism (DBH50-Ins/Del) and schizophrenia in a Han Chinese population. Methods: This polymorphism was genotyped in 221 first-episode schizophrenics, 360 chronic schizophrenics and 318 healthy controls using a case-control design. We assessed their psychopathology using the Positive and Negative …
Decreased Density Of Serotonin 2a Receptors In The Superior Temporal Gyrus In Schizophrenia - A Postmortem Study, Xu-Feng Huang, Chao Deng, Qing Wang, Kai Kang
Decreased Density Of Serotonin 2a Receptors In The Superior Temporal Gyrus In Schizophrenia - A Postmortem Study, Xu-Feng Huang, Chao Deng, Qing Wang, Kai Kang
Xu-Feng Huang
The superior temporal gyrus (STG) is strongly implicated in the pathophysiology of schizophrenia,particularly with regards to auditory hallucinations. In this study, using in situ quantitative autoradiography in postmortem tissue, we investigated the binding of the [3H]ketanserin to 5-HT2A receptors and [3H] mesulergine to 5-HT2C receptors in the left STG of 8 male schizophrenic patients compared to 8 control subjects. A strong [3H]ketanserin binding was observed in the STG, however there was a very weak [3H] mesulergine binding in the STG. A significant decrease in binding of [3H]ketanserin was clearly observed in schizophrenia patients in comparison with control subjects. There were …
The Schizophrenia Susceptibility Gene Neuregulin 1 Modulates Tolerance To The Effects Of Canabinoids, Aurelie Boucher, Glenn E. Hunt, Jacques Micheau, Xu-Feng Huang, Iain Mcgregor, Tim Karl, Jonathon Arnold
The Schizophrenia Susceptibility Gene Neuregulin 1 Modulates Tolerance To The Effects Of Canabinoids, Aurelie Boucher, Glenn E. Hunt, Jacques Micheau, Xu-Feng Huang, Iain Mcgregor, Tim Karl, Jonathon Arnold
Xu-Feng Huang
Cannabis increases the risk of schizophrenia in genetically vulnerable individuals. In this study we aim to show that the schizophrenia susceptibility gene neuregulin 1 (Nrg1) modulates the development of tolerance to cannabinoids in mice. Nrg1 heterozygous (HET) and wild-type (WT) mice were treated daily for 15 d with the synthetic analogue of D9-tetrahydrocannabinol, CP55,940 (0.4 mg/kg). We measured the impact of this exposure on locomotor activity, anxiety, prepulse inhibition (PPI), body temperature and FosB/DFosB immunohistochemistry. Tolerance to CP55,940-induced hypothermia and locomotor suppression developed more rapidly in Nrg1 HET mice than WT mice. Conversely in the light-dark test, while tolerance to …
Increased Cannabinoid Receptor Density In The Posterior Cingulate Cortex In Schizophrenia, Kelly Newell, Xu-Feng Huang, Chao Deng
Increased Cannabinoid Receptor Density In The Posterior Cingulate Cortex In Schizophrenia, Kelly Newell, Xu-Feng Huang, Chao Deng
Xu-Feng Huang
No abstract provided.
Membrane Phospholipid Composition, Alterations In Neurotransmitter Systems And Schizophrenia, Xu-Feng Huang, Chao Deng, Teresa Du Bois
Membrane Phospholipid Composition, Alterations In Neurotransmitter Systems And Schizophrenia, Xu-Feng Huang, Chao Deng, Teresa Du Bois
Xu-Feng Huang
No abstract provided.
No Changes In Densities Of Cannabinoid Receptors In The Superior Temporal Gyrus In Schizophrenia, Xu-Feng Huang, Chao Deng, Mei Han
No Changes In Densities Of Cannabinoid Receptors In The Superior Temporal Gyrus In Schizophrenia, Xu-Feng Huang, Chao Deng, Mei Han
Xu-Feng Huang
Objective: In recent years, abnormal changes in the endocannabinoid system have been found in schizophrenia. The superior temporal gyrus (STG) is strongly implicated in the pathophysiology of schizophrenia, particularly with regards to auditory hallucinations. In this study, we investigated the binding density of cannabinoid CB1 receptors in the STG of schizophrenia patients compared to control subjects. Methods: Quantitative autoradiography was used to investigate the binding densities of [3H] SR141716A (a selective antagonist) and [3H]CP-55940 (an agonist) to the CB1 receptors in the STG. Post-mortem brain tissue was obtained from the NSW Tissue Resource Centre (Australia). Results: Contrasting to previous findings …
Increased Density Of Gabaa Receptors In The Superior Temporal Gyrus In Schizophrenia, Xu-Feng Huang, Chao Deng
Increased Density Of Gabaa Receptors In The Superior Temporal Gyrus In Schizophrenia, Xu-Feng Huang, Chao Deng
Xu-Feng Huang
No abstract provided.
Decreased Density Of Muscarinic Receptors In The Superior Temporal Gyrus In Schizophrenia, Xu-Feng Huang, Chao Deng
Decreased Density Of Muscarinic Receptors In The Superior Temporal Gyrus In Schizophrenia, Xu-Feng Huang, Chao Deng
Xu-Feng Huang
No abstract provided.
M2/M4 Muscarinic Receptor Binding In The Anterior Cingulate Cortex In Schizophrenia And Mood Disorders, Xu-Feng Huang, Katerina Zavitsanou, Andrew Katsifis, Yinghua Yu
M2/M4 Muscarinic Receptor Binding In The Anterior Cingulate Cortex In Schizophrenia And Mood Disorders, Xu-Feng Huang, Katerina Zavitsanou, Andrew Katsifis, Yinghua Yu
Xu-Feng Huang
No abstract provided.
Ionotropic Glutamate Receptor Binding In The Posterior Cingulate Cortex In Schizophrenia Patients, Kelly Newell, Xu-Feng Huang, Katerina Zavitsanou
Ionotropic Glutamate Receptor Binding In The Posterior Cingulate Cortex In Schizophrenia Patients, Kelly Newell, Xu-Feng Huang, Katerina Zavitsanou
Xu-Feng Huang
No abstract provided.
Rapid Cortico-Limbic Alterations In Ampa Receptor Densities After Administration Of Pcp: Implications For Schizophrenia., Van Nguyen, Kelly Newell, Xu-Feng Huang, Katerina Zavitsanou, P Ballantyne
Rapid Cortico-Limbic Alterations In Ampa Receptor Densities After Administration Of Pcp: Implications For Schizophrenia., Van Nguyen, Kelly Newell, Xu-Feng Huang, Katerina Zavitsanou, P Ballantyne
Xu-Feng Huang
Phencyclidine (PCP), a non-competitive NMDA/glutamate receptor antagonist, is a psychotomimetic drug that produces a syndrome in normal humans that resembles schizophrenia. The present study investigated the mechanisms of PCP actions by examining the density of glutamate and muscarinic receptors in the rat brain 4 h after a single injection of PCP. We used receptor autoradiography and [3H]MK801, [3H]AMPA, [3H]pirenzepine and [3H]AFDX384 to target glutamate NMDA, glutamate AMPA and muscarinic M1 and M2 receptors, respectively. The major outcome from the present study was an overall decrease in levels of the glutamate AMPA receptor density (F = 14.5, d.f. = 1, p …
Alterations Of Muscarinic And Gaba Receptor Binding In The Posterior Cingulate Cortex In Schizophrenia, Kelly Newell, Xu-Feng Huang, Katerina Zavitsanou, Stephen Kum Jew
Alterations Of Muscarinic And Gaba Receptor Binding In The Posterior Cingulate Cortex In Schizophrenia, Kelly Newell, Xu-Feng Huang, Katerina Zavitsanou, Stephen Kum Jew
Xu-Feng Huang
No abstract provided.
Immune Factors In The Neuregulin-1 Knockout Mouse Model Of Schizophrenia, P Snikeris, Xu-Feng Huang, Elisabeth T. Frank
Immune Factors In The Neuregulin-1 Knockout Mouse Model Of Schizophrenia, P Snikeris, Xu-Feng Huang, Elisabeth T. Frank
Xu-Feng Huang
No abstract provided.