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Methods For The Establishment Of A Dss-Induced Ibd Model In Adult Zebrafish, Ningxiang Zeng Jan 2019

Methods For The Establishment Of A Dss-Induced Ibd Model In Adult Zebrafish, Ningxiang Zeng

All ETDs from UAB

Inflammatory Bowel Disease (IBD) is a group of idiopathic chronic inflammatory intestinal conditions. To reveal its pathogenesis, several different animal models have been established. Although no single model captures the complexity of human IBD, each model provides valuable insights into one or another major aspect of disease, and together they have led to the establishment of a generally accepted understanding for human IBD pathogenesis. Recently, zebrafish have become an important platform for IBD research, and several murine IBD outcomes have been adapted to the zebrafish. Dextran Sulfate Sodium (DSS) -induced colitis, the most widely used murine IBD model, has never …


Structural Elements Underlying The Neuroplastic Changes Produced By Constraint-Induced Movement Therapy In Chronic Stroke, Yue Zhang Jan 2019

Structural Elements Underlying The Neuroplastic Changes Produced By Constraint-Induced Movement Therapy In Chronic Stroke, Yue Zhang

All ETDs from UAB

Constraint-Induced Movement Therapy (CIMT) is a rehabilitation treatment that produces large motor function improvements in patients with chronic stroke. One of the hypothesized mechanisms by which CIMT achieves its therapeutic effect is the large functional and structural plastic changes that it produces in the brain. The goal of the present project was to determine the neural underpinnings of cortical reorganization produced by CIMT in chronic stroke using proton magnetic resonance spectroscopy (1H-MRS). Before applying the proposed 1H-MRS techniques (i.e., single voxel spectroscopy/SVS and whole brain magnetic resonance spectroscopic imaging/WB-MRSI) to evaluate longitudinal changes in brain metabolites after CIMT, it is …


Predictors Of School Weapon Carrying Among Adolescents, Jonathan Adams Jan 2019

Predictors Of School Weapon Carrying Among Adolescents, Jonathan Adams

All ETDs from UAB

The presence of weapons threatens the safety of all individuals on school grounds. Emergent research suggests factors linked to school weapon carrying may stem from both within and outside the school environment; however, few efforts have been made to identify a comprehensive set of risk and protective factors associated with school weapon carrying. To address this gap, the first manuscript serves as a comprehensive, systematic review of variables associated with higher or lower likelihood an adolescent will carry weapons to school. Results indicated higher rates of weapon carrying among individuals who are male, sexual minority, children of single parents; exhibit …


Impact Of Familial Chronic Illness On Adolescent Somatization, Lindsey Elliott Jan 2019

Impact Of Familial Chronic Illness On Adolescent Somatization, Lindsey Elliott

All ETDs from UAB

Somatic symptoms, or physical symptoms that do not have an identifiable organic etiology, have a prevalence of 10-30% in children. They have been associated with poor psychosocial outcomes in children, including emotional and behavioral problems, school absences, and impaired social functioning. Further, these symptoms represent a burden on the health care system as patients with somatic symptoms are frequent users of both primary care physicians and specialists. The etiology of somatic symptoms is thought to be due to a combination of biological, psychological, interpersonal, and healthcare factors. Two theories exist regarding the etiology of somatic symptoms. Brown’s integrative conceptual model …


Unintentional Childhood Injuries In Rural Uganda: The Role Of Sibling Supervision And The Potential For Behavior Change Through Classroom-Based Instruction, Marissa Swanson Jan 2019

Unintentional Childhood Injuries In Rural Uganda: The Role Of Sibling Supervision And The Potential For Behavior Change Through Classroom-Based Instruction, Marissa Swanson

All ETDs from UAB

Objective: Unintentional childhood injury is a significant global health burden particularly in low and middle income countries (LMIC). Effective supervision can reduce risk of injury to supervisees. Frequently, older siblings assist in supervising younger siblings, but may not be as effective as adult caregivers at preventing supervisee injury. The current investigation had three primary objectives: 1) Assess Ugandan adult caregivers’ self-reported expectations for children to provide sibling supervision; 2) Assess sixth-grade students’ self-reported experiences providing supervision; 3) Determine whether students’ supervision knowledge and skill improve through participation in the Super Siblings program, a novel classroom-based, culturally-adapted intervention. Methods: Adult caregivers …


Racial And Gender Differences In The Relationship Between Adverse Childhood Experience And Chronic Health Conditions In Adulthood, Jalal Uddin Jan 2019

Racial And Gender Differences In The Relationship Between Adverse Childhood Experience And Chronic Health Conditions In Adulthood, Jalal Uddin

All ETDs from UAB

A growing body of studies highlights that many adult diseases and health disparities in late-life are rooted in childhood adversities. However, there is little research that examines how social stratification processes structure the inequality in early-life stress exposure, and the effects of stress exposure on health outcomes may vary based on the intersections of social stratification categories. Drawing on an integrated framework of the life course stress process and intersectionality theory, this study examines the patterns in childhood adverse experiences (ACEs) by race/ethnicity and gender and how race/ethnicity, gender, and adult socioeconomic status (SES) combine to modify the effects of …


Photo-Induced Electron Paramagnetic Resonance Study Of Charge Transfer In Compensated Gallium Nitride Substrates Grown By The High Nitrogen Pressure Solution Method, William Ryan Willoughby Jan 2019

Photo-Induced Electron Paramagnetic Resonance Study Of Charge Transfer In Compensated Gallium Nitride Substrates Grown By The High Nitrogen Pressure Solution Method, William Ryan Willoughby

All ETDs from UAB

Charge transfer occurring in semi-insulating GaN crystals grown by the high nitrogen pressure solution (HNPS) method was investigated using electron paramagnetic resonance (EPR) spectroscopy. Samples were semi-insulating due to compensation of residual shallow oxygen donors with Mg and/or Be acceptor impurities. EPR was detected after illumination with photon energies greater than 2.7 eV in samples containing at least $10^{17} \textnormal{ cm\textsuperscript{-3}}$ beryllium atoms. The resonance consisted of two Gaussian lines. One was stable at temperatures less than 25 K with isotropic $g=1.989$ and was attributed to a paramagnetic neutral acceptor state. This resonance was quenched with photon energies between 0.5 …


Transition Into Adulthood: Cannabis Use And Mental Health, Katie Mcintyre Jan 2019

Transition Into Adulthood: Cannabis Use And Mental Health, Katie Mcintyre

All ETDs from UAB

The US is currently experiencing sweeping changes in the legal status of cannabis, the most common illicit drug used in America. Due to its classification as a Schedule I substance we know very little about how cannabis use impacts mental health since illicit drugs are not legally allowed to be researched in a laboratory setting. The current research on cannabis use (CU) and mental health (MH) is expansive and conflicting. One side of the debate suggests CU in adolescence has a direct effect on MH, the other side suggests CU could be an indirect coping mechanism of poor MH. One …


Inverse Problems, Regularization And Its Applications, Abinash Nayak Jan 2019

Inverse Problems, Regularization And Its Applications, Abinash Nayak

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Inverse problems arise in a wide spectrum of applications in fields ranging from engineering to scientific computation. Connected with the rise of interest in inverse problems is the development and analysis of regularization methods, such as truncated singular value decomposition (TSVD), Tikhonov regularization or iterative regularization methods (like Landerweb iterations), which are a necessity in most inverse problems due to their ill-posedness. TSVD can be used when dealing with (small) finite dimensional linear problems, but is computationally very expensive, and sometimes even unfeasible, for large scale linear problems or nonlinear problems. In such scenarios, Tikhonov regularization is an attractive alternative, …


Rituals Of Reconciliation: The Use Of Peaceful Interactions To Repair Relationships, Sheila Renee Gainer Jan 2019

Rituals Of Reconciliation: The Use Of Peaceful Interactions To Repair Relationships, Sheila Renee Gainer

All ETDs from UAB

Reconciliation is the process by which social animals maintain valuable social relationships. It has been documented in many species including humans and nonhuman primates. While evidence of rituals has been seen in other species, the primary aim of this research is to explore how ritual behaviors are interconnected to human acts of reconciliation. Rituals are habitual activities closely linked to important events and reaffirm the identity of those who practice them as a group or a society. They are found in every society, culture and religion. In this study, rituals specifically related to reconciliation were exhibited in 27 of 138 …


The Influence Of Child, Parent, And Context Factors On Children’S Traffic Injury Risk, Emma Sartin Goodman Jan 2019

The Influence Of Child, Parent, And Context Factors On Children’S Traffic Injury Risk, Emma Sartin Goodman

All ETDs from UAB

Child restraint systems, like car seats and booster seats, are effective at preventing serious injury and death for children involved in motor vehicle collisions. Despite this, the majority of families in the United States either do not use, or incorrectly use, child restraint systems. Further, racial minorities are consistently reported to have higher rates of child restraint system non- and misuse than their White peers; research has yet to explain this relationship with previously hypothesized factors (e.g., caregiver education, sources of information). The overall objective of this project was to explain how child, caregiver, and context factors interacted to influence …


High-Pressure Studies On Borosilicate And Bulk Metallic Glasses, Kathryn Jinae Ham Jan 2019

High-Pressure Studies On Borosilicate And Bulk Metallic Glasses, Kathryn Jinae Ham

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Multi-angle energy-dispersive X-ray diffraction (EDXD) and white-beam radiography studies were conducted on a borosilicate glass sample (17.6% B2O3) to 13.7 GPa in a Paris-Edinburgh (PE) press at Beamline 16-BM-B, HPCAT, The Advanced Photon Source, Argonne National Laboratory. The measured structure factor S(q) to q = 19 Å-1 was used to determine internuclear bond distances between various species of atoms contained in the glass sample. Bond distances for Si-O, O-O, and Si-Si were determined from the reduced pair distribution function G(r) and were measured as a function of pressure. The sample height, as determined via white-beam radiography, showed an overall …


Relationship Between Frustration Tolerance And Psychological Self-Regulatory Mechanisms In Weight Loss Maintenance, Samantha Kaytana Henry Jan 2019

Relationship Between Frustration Tolerance And Psychological Self-Regulatory Mechanisms In Weight Loss Maintenance, Samantha Kaytana Henry

All ETDs from UAB

The present study investigated the relevance of frustration tolerance and other psychological regulation factors (e.g., trait mindfulness, executive function) to long-term weight maintenance. Using a cross-sectional design, participants (N=91) were recruited from three behavioral weight loss interventions and categorized dichotomously (maintainer vs. regainer) based on their level of success in maintaining weight loss long term. Participants completed the Frustration Discomfort Scale (FDS), objective measures of executive functioning (EF), and self-report questionnaires. Poorer frustration tolerance was significantly associated with lower trait mindfulness, higher negative affectivity, and greater difficulties in self-reported EF. There were no differences by race or weight maintenance status. …


Social Support And Self-Care Efficacy As Mediators Of Racial Disparities In Diabetes Health In Older Adults, Wesley Browning Jan 2019

Social Support And Self-Care Efficacy As Mediators Of Racial Disparities In Diabetes Health In Older Adults, Wesley Browning

All ETDs from UAB

Diabetes is a health problem that affects millions of Americans annually, and Black Americans have a higher prevalence with more complications than White Americans. A disparity exists between Black and White older adults living with diabetes in distress related to symptoms, treatment, and complications associated with the disease. Additionally, there are differences in levels of performing diabetes self-care behaviors between Blacks and Whites. One series of factors that may predict better diabetes self-care and diabetes distress in older adults are self-care efficacy and components of social support. This study used linear regression models to predict racial differences between Blacks and …


The Effects Of Saha And Egcg On Metastatic Potential In Triple-Negative Breast Cancer Cells, Kayla Lewis Steed Jan 2019

The Effects Of Saha And Egcg On Metastatic Potential In Triple-Negative Breast Cancer Cells, Kayla Lewis Steed

All ETDs from UAB

About 1 in 8 women will be diagnosed with breast cancer at some time in their lives, and more than 40,000 women will die due to breast cancer this year. Women do not die from localized breast cancer cases but from metastatic, or Stage IV, breast cancer (MBC). Over 150,000 women are currently living with MBC, and treatments focus on length and quality of life considering there is no cure. Triple-negative breast cancers (TNBC) do not respond to targeted therapies as they are lacking estrogen receptor alpha (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). They …


Person Re-Identification By Deep Structured Prediction: A Generative Approach, Xinpeng Liao Jan 2019

Person Re-Identification By Deep Structured Prediction: A Generative Approach, Xinpeng Liao

All ETDs from UAB

Visual appearance based person re-identification (re-ID) is the task of assigning the same identifier to all instances of a particular individual captured in images or videos, even after the occurrence of significant gaps over time or space. The state-of-the-art methods can be categorized into two main approaches: Given a set of gallery images with known IDs, the task is to infer either the ID label of a probe image individually (person re-ID via image retrieval) or the collective ID labeling of all probe images simultaneously (person re-ID via a highly-crafted re-ID structure). This dissertation is primarily focused on exploring the …


My Bully's Mouth, Wendy Rawlings Jan 2019

My Bully's Mouth, Wendy Rawlings

Nelle

pp. 74-84


First Home, Susannah Felts Jan 2019

First Home, Susannah Felts

Nelle

pp. 61-62


Nelle 2 (End Matter), Nelle Staff Jan 2019

Nelle 2 (End Matter), Nelle Staff

Nelle

pp. 95-101


Showing The Father, Mary B. Moore Jan 2019

Showing The Father, Mary B. Moore

Nelle

pp. 3-7


Fox, Jane Satterfield Jan 2019

Fox, Jane Satterfield

Nelle

pp. 22-23


Comparison Of Longitudinal Voxel-Based Morphometry (Vbm) And Tensor-Based Morphometry (Tbm) For Detecting Structural Use-Dependent Neuroplastic Changes After Constraint-Induced Movement Therapy, Brent Maddox Womble Jan 2019

Comparison Of Longitudinal Voxel-Based Morphometry (Vbm) And Tensor-Based Morphometry (Tbm) For Detecting Structural Use-Dependent Neuroplastic Changes After Constraint-Induced Movement Therapy, Brent Maddox Womble

All ETDs from UAB

Constraint-Induced Movement therapy (CI therapy) is an efficacious physical rehabilitation intervention for lateralized upper-extremity motor deficits resulting from neurological injury or disease, which has been shown to result in use-dependent structural and functional neuroplasticity. While use-dependent neuroplasticity has been shown to result in structural changes in brain tissue density, thickness, and volume, the exact cellular mechanisms underpinning this neuroplasticity in humans have yet to be determined. The present study involved a novel use of synthetic data, with the overall aim of elucidating the nature of structural use-dependent neuroplasticity produced by CI therapy. Longitudinal voxel-based morphometry (VBM) and tensor-based morphometry (TBM) …


Recognizing Compound Expressions And Emotion Intensity, William Wagner Jan 2019

Recognizing Compound Expressions And Emotion Intensity, William Wagner

All ETDs from UAB

Six facial expressions of emotion (anger, disgust, fear, happiness, sadness, and surprise) have been identified as panculturally recognizable. Though recognition of those facial expressions appears to be developmentally innate, there is variation in emotion recognition between individuals. Specifically, those with autism spectrum disorder often have difficulty with this skill, contributing to issues in their social interactions. Another important skill for social interactions is identifying when someone feels more than one emotion at a time, and some evidence suggests that those emotional states are expressed with panculturally recognizable affects, termed compound expressions. Yet another skill involves determining the intensity of someone’s …


Perceptions Of The Police By Queer Women, Marshall Lorraine White Jan 2019

Perceptions Of The Police By Queer Women, Marshall Lorraine White

All ETDs from UAB

Queer communities have historically had a strained relationship with the police. In recent years, scholars have begun to examine perceptions of the police by these communities in an attempt to fill an important gap in the literature. The current study examines perceptions of the police by queer women in Birmingham, AL. The focus on queer women is attributed to recent findings that queer women (lesbian, bisexual, transgender, etc.) report more negative perceptions of the police than others in queer communities. Semi-structured interviews were conducted with 17 self-identified White, queer women about their experiences growing up, broad views about the police, …


Genomic Insight Into The Gut Microbiome Of The Sea Urchins Lytechinus Variegatus And Strongylocentrotus Purpuratus Revealed Distinct Community Compositions And Their Metabolic Profiles, Joseph Antoine Hakim Jan 2019

Genomic Insight Into The Gut Microbiome Of The Sea Urchins Lytechinus Variegatus And Strongylocentrotus Purpuratus Revealed Distinct Community Compositions And Their Metabolic Profiles, Joseph Antoine Hakim

All ETDs from UAB

For over 500 million years, our planet’s self-replicating prokaryotes have colonized multicellular host organisms, forging complex interdependent relationships under the selective pressures of the natural environment. Recently, the use of high-throughput sequencing (HTS) technology targeting metacommunity DNA has uncovered the unprecedented diversity and metabolic processes of these communities. Such information has extensively been investigated in the guts of higher bilaterian organisms, such as mammals including humans. One of the early bilaterian organisms that have been linked to humans are the sea urchins, the gut microbiota of which have not been sufficiently studied. Thus, the objective of this dissertation was to …


Automating Personal Safety Among Different Age Groups, Jayun Patel Jan 2019

Automating Personal Safety Among Different Age Groups, Jayun Patel

All ETDs from UAB

Personal Safety has always been crucial to one’s life. Many different threats are faced by people in their day to day lives. These threats differ with different age groups that affect their health and well being. Different threats affect people, which include birth defects, falls, drowning, health problems, abuse, suicide, homicide, and sexual violence [39]. Many other threats occur every day but these threats are the common threats that are faced by most of the people at different ages. These threats can affect the victims in terms of the health of the person, and the physical and mental well being …


Deciphering The Roles Of Hopd1 In Carbon Metabolism During Pathogen Infection, Yali Sun Jan 2019

Deciphering The Roles Of Hopd1 In Carbon Metabolism During Pathogen Infection, Yali Sun

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Plants are equipped with various immune responses including MAMP-triggered immunity (MTI) and effector-triggered immunity (ETI) to fight against pathogens, while virulent pathogens release virulent proteins (effectors) and phytotoxins to compete with host immune responses. Comprehensively, plant-pathogen interactions involve multi- layered and highly coordinated processes, and dynamic regulation at both transcriptional and translational levels plays a pivotal role in plant defense. For example, NPR1, a key immune regulator, is regulated by hosts and manipulated by pathogens at different levels during different stages of plant-pathogen interaction. However, besides the competition over immune responses, bacterial pathogens also need to gain nutrients from host …


The Weight Of Social Relationships: Social Network Analysis In An Adult Weight Loss Program, Alena Borgatti Jan 2019

The Weight Of Social Relationships: Social Network Analysis In An Adult Weight Loss Program, Alena Borgatti

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Adult behavioral obesity interventions often show improved attendance and weight loss when delivered in a group, as opposed to individual, therapy format. However, research on the exact mechanisms through which group therapy confers additional weight loss is lacking. Pediatric obesity interventions have recently begun to utilize social network analysis (SNA) to identify structural ties that may improve adherence and weight loss; however, this research is limited and has yet to be replicated in an adult weight loss program. The current study is the first to evaluate social networks in an adult behavioral weight loss intervention. Four weight loss groups were …


A Scalable Nearline Disk Archive Storage Architecture For Extreme Scale High Performance Computing, Hampton Walker Haddock Jan 2019

A Scalable Nearline Disk Archive Storage Architecture For Extreme Scale High Performance Computing, Hampton Walker Haddock

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Parallel file systems that exploit Redundant Arrays of Inexpensive Devices (RAID) as the mechanism for greater resilience are primarily intended to provide high bandwidth and low latency. Quantifying and studying the trade-offs among reduced run time (bandwidth and latency), resilience (availability and integrity), and cost (energy and capital) is important. For instance, distributing the checksums of RAID systems appears in conflict with the canonical parallel access patterns in high performance computing such as long sequential reads, random access, and checkpoint operations. Choices consequently have to be made between performance, concurrency, latency, energy, capital, integrity and availability of the data for …


Perceptions Of African-American Teachers Concerning African-American Youth, D'Antranett Hicks-Stewart Jan 2019

Perceptions Of African-American Teachers Concerning African-American Youth, D'Antranett Hicks-Stewart

All ETDs from UAB

Perceptions of African American youth have been illustrated by how they are perceived on television: as deviants, criminals and unteachable. These perceptions are also illustrated in the behaviors of teachers in both inner-city and suburban schools. African American teachers in the inner-city schools have hope of changing the world for the better until they are met with difficult challenges presented by African-American students. Some students are excellent and some not so excellent. The structural environment of African-American youth can so strongly influence their behavior, that they begin to take on their perceptions. This can be seen in their choice friends, …