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Full-Text Articles in Arts and Humanities
When Are Research Risks Reasonable In Relation To Anticipated Benefits?, Charles Weijer, Paul Miller
When Are Research Risks Reasonable In Relation To Anticipated Benefits?, Charles Weijer, Paul Miller
Charles Weijer
The question "When are research risks reasonable in relation to anticipated benefits?" is at the heart of disputes in the ethics of clinical research. Institutional review boards are often criticized for inconsistent decision-making, a problem that is compounded by a number of contemporary controversies, including the ethics of research involving placebo controls, developing countries, incapable adults and emergency rooms. If this pressing ethical question is to be addressed in a principled way, then a systematic approach to the ethics of risk in research is required. Component analysis provides such a systematic approach.
Will The Real Charles Fried Please Stand Up?, Paul Miller, Charles Weijer
Will The Real Charles Fried Please Stand Up?, Paul Miller, Charles Weijer
Charles Weijer
In response to the preceding commentary by Jerry Menikoff in this issue of the Journal, the authors argue that Fried's central concern is not that randomized clinical trials (RCTs) are conducted without consent, but rather that various aspects of the design and conduct of RCTs are in tension with physicians' duties of personal care to their patients. Although Fried does argue that the existence of equipoise cannot justify failure to obtain consent from research subjects, informed consent by itself does not supplant ill subjects' rights to personalized judgment and care embodied in Fried's equipoise.
Therapeutic Obligation In Clinical Research, Charles Weijer, Paul Miller
Therapeutic Obligation In Clinical Research, Charles Weijer, Paul Miller
Charles Weijer
No abstract provided.
I Need A Placebo Like I Need A Hole In The Head, Charles Weijer
I Need A Placebo Like I Need A Hole In The Head, Charles Weijer
Charles Weijer
No abstract provided.
Moral Solutions In Assessing Research Risk, Paul Miller, Charles Weijer
Moral Solutions In Assessing Research Risk, Paul Miller, Charles Weijer
Charles Weijer
No abstract provided.
Thinking Clearly About Research Risk: Implications Of The Work Of Benjamin Freedman, Charles Weijer
Thinking Clearly About Research Risk: Implications Of The Work Of Benjamin Freedman, Charles Weijer
Charles Weijer
No abstract provided.
The Irb's Role In Assessing The Generalizability Of Non-Nih-Funded Clinical Trials, Charles Weijer
The Irb's Role In Assessing The Generalizability Of Non-Nih-Funded Clinical Trials, Charles Weijer
Charles Weijer
No abstract provided.
Placebo Orthodoxy In Clinical Research I: Empirical And Methodological Myths, Benjamin Freedman, Charles Weijer, Kathleen Glass
Placebo Orthodoxy In Clinical Research I: Empirical And Methodological Myths, Benjamin Freedman, Charles Weijer, Kathleen Glass
Charles Weijer
No abstract provided.
Placebo Orthodoxy In Clinical Research Ii: Ethical, Legal, And Regulatory Myths, Benjamin Freedman, Kathleen Glass, Charles Weijer
Placebo Orthodoxy In Clinical Research Ii: Ethical, Legal, And Regulatory Myths, Benjamin Freedman, Kathleen Glass, Charles Weijer
Charles Weijer
No abstract provided.
The Duty To Exclude: Excluding People At Undue Risk From Research, Charles Weijer, Abraham Fuks
The Duty To Exclude: Excluding People At Undue Risk From Research, Charles Weijer, Abraham Fuks
Charles Weijer
The clinical trial is the major investigational tool of clinical medicine. Two recent reports highlight the fact that the most often quoted mechanisms for the protection of research subjects, viz., research ethics board review and eligibility criteria, are insufficient to achieve this end. In this paper, we argue that the prime mechanism for the protection of persons in clinical trials should be the clinical judgement of the physician-investigator. The clinical investigator has a duty to protect subjects from both harm and undue risk. It is argued that the clinical investigator has a duty to screen for, and exclude, potential research …
In Loco Parentis: Minimal Risk As An Ethical Threshold For Research Upon Children, Benjamin Freedman, Abraham Fuks, Charles Weijer
In Loco Parentis: Minimal Risk As An Ethical Threshold For Research Upon Children, Benjamin Freedman, Abraham Fuks, Charles Weijer
Charles Weijer
No abstract provided.
Demarcating Research And Treatment: A Systematic Approach For The Analysis Of The Ethics Of Clinical Research, Benjamin Freedman, Abraham Fuks, Charles Weijer
Demarcating Research And Treatment: A Systematic Approach For The Analysis Of The Ethics Of Clinical Research, Benjamin Freedman, Abraham Fuks, Charles Weijer
Charles Weijer
No abstract provided.
[Demarcating Research And Treatment Interventions: A Case Illustration]: Commentary, Benjamin Freedman, Charles Weijer
[Demarcating Research And Treatment Interventions: A Case Illustration]: Commentary, Benjamin Freedman, Charles Weijer
Charles Weijer
No abstract provided.