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Full-Text Articles in Arts and Humanities
Cruel And Unusual Treatment, Carl Elliott, Charles Weijer
Cruel And Unusual Treatment, Carl Elliott, Charles Weijer
Charles Weijer
No abstract provided.
Characterizing The Population In Clinical Trials: Barriers, Comparability, And Implications For Review, Charles Weijer
Characterizing The Population In Clinical Trials: Barriers, Comparability, And Implications For Review, Charles Weijer
Charles Weijer
The definition of the study population for a clinical trial via the criteria for trial eligibility has implications for the validity of the study and its applicability to clinical practice. Though issues of equity regarding the selection of subjects for research have long been a concern of ethicists, issues regarding the impact of subject selection on a trial's generalizability have only recently attracted ethical scrutiny. After a review of the history of the ethics of subject selection, I focus on three empirical questions regarding the generalizability of clinical trials. (1) What proportion of diseased populations are studied in clinical trials? …
The Breast Cancer Research Scandal: Addressing The Issues, Charles Weijer
The Breast Cancer Research Scandal: Addressing The Issues, Charles Weijer
Charles Weijer
The three claims put forward by Dr. Roger Poisson to rationalize his enrollment of ineligible subjects in clinical trials do not justify research fraud. None the less, certain lessons for the conduct of clinical research can be learned from the affair: experimental therapies should be made available to technically ineligible subjects when no effective therapy exists for their disease; further research must investigate the possible benefits of clinical-trial participation; broadly based, pragmatic trials must be regarded as the ideal model; and each eligibility criterion in a clinical-trial protocol should be justified.