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Sex Steroid Metabolism Polymorphisms And Mammographic Density In Pre- And Early Perimenopausal Women, Carolyn J. Crandall, Mary E. Sehl, Sybil L. Crawford, Ellen B. Gold, Laurel A. Habel, Lesley M. Butler, Mary Fran R. Sowers, Gail A. Greendale, Janet S. Sinsheimer
Sex Steroid Metabolism Polymorphisms And Mammographic Density In Pre- And Early Perimenopausal Women, Carolyn J. Crandall, Mary E. Sehl, Sybil L. Crawford, Ellen B. Gold, Laurel A. Habel, Lesley M. Butler, Mary Fran R. Sowers, Gail A. Greendale, Janet S. Sinsheimer
Sybil L. Crawford
INTRODUCTION : We examined the association between mammographic density and single-nucleotide polymorphisms (SNPs) in genes encoding CYP1A1, CYP1B1, aromatase, 17beta-HSD, ESR1, and ESR2 in pre- and early perimenopausal white, African-American, Chinese, and Japanese women. METHODS : The Study of Women's Health Across the Nation is a longitudinal community-based cohort study. We analyzed data from 451 pre- and early perimenopausal participants of the ancillary SWAN Mammographic Density study for whom we had complete information regarding mammographic density, genotypes, and covariates. With multivariate linear regression, we examined the relation between percentage mammographic breast density (outcome) and each SNP (primary predictor), adjusting for …