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Investigation Of Optimal Dosing Strategies For Ertapenem For Varying Bmi Using Mathematical Modeling, Bethany Jewett

Undergraduate Honors Theses

Previous research suggests that the efficacy of Ertapenem, a carbapenem antibiotic administered intravenously, is related to a patient’s body mass index. Using an existing physiologically based pharmacokinetic (PBPK) model for Ertapenem, we constructed a least squares inverse problem to determine an optimal dose for males with varying body weights and heights. The criteria for an optimal dose was based upon pharmacokinetic and pharmacodynamic (PK/PD) parameters calculated for a male with a body height of 175 cm and a weight of 72 kg. We also adjusted dosing intervals to ensure that effective concentration of drug between doses was the same for …