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Full-Text Articles in Arts and Humanities

Review Of Alcohol And Drug Treatment For Aboriginal And Torres Strait Islander Peoples, Marguerite Tracy, Bradley Freeburn, Kylie Lee, Julie Woods, Kate Conigrave Jan 2023

Review Of Alcohol And Drug Treatment For Aboriginal And Torres Strait Islander Peoples, Marguerite Tracy, Bradley Freeburn, Kylie Lee, Julie Woods, Kate Conigrave

Journal of the Australian Indigenous HealthInfoNet

This review provides an overview of treatments for problem alcohol and other drug (AOD) use for Aboriginal and Torres Strait Islander people. It includes information on the available research and discusses core principles for providing treatment. The review outlines how effective mainstream treatment approaches can be adapted to be more suitable for Aboriginal and Torres Strait Islander ways of being or worldview. It also highlights that services, such as those offered by Aboriginal community controlled health organisations are in a unique position to offer culturally secure treatment approaches. The barriers to accessing treatment are discussed as well as recommendations for …


Strengthening Adolescents With Anxiety Through Drama Therapy, Jeremy M. Moeller Apr 2022

Strengthening Adolescents With Anxiety Through Drama Therapy, Jeremy M. Moeller

Belmont University Research Symposium (BURS)

Strengthening Adolescents with Anxiety Through Drama Therapy

Jeremy Moeller

In recent years the issues associated with social anxiety have become increasingly common in adolescents. With these issues becoming more common it is important that they continue to be nurtured and helped. With so many forms of therapy though it may be hard for someone to find a practice that suits them. That is where drama therapy comes in. Drama therapy is a fairly new practice that helps these adolescents to become more expressive and engaging in their everyday lives, decrease their social anxieties, and build a new sense of confidence …


Shukri Ayyad As A Stylistic ‎Critic, Hussam Ayoub Nov 2021

Shukri Ayyad As A Stylistic ‎Critic, Hussam Ayoub

Jerash for Research and Studies Journal مجلة جرش للبحوث والدراسات

This research paper consists of an introduction and three themes, The themes are:‎‎1-‎ The factors.‎‎2-‎ The principles of stylistic theory.‎‎3-‎ The application.‎‎ The introduction covers the significance of this research paper and the approach followed in ‎the study.‎The first theme discusses most of the factor which participated in the coinage of the ‎stylistic theory of ShukriAyyad such as Arabic Theories, modem linguistics and the ‎translation of modern stylistic studies.‎‎ The second theme discusses the principles of Ayyad stylistic theory such as the ‎relationship between stylistics and literary criticism the concept of stylistic ‎phenomenon and the standards used in observing its …


The Experience Of Conflicting Identities Amongst African American Law Enforcement Officers, Jeremy R. Jones Jan 2021

The Experience Of Conflicting Identities Amongst African American Law Enforcement Officers, Jeremy R. Jones

Walden Dissertations and Doctoral Studies

Law enforcement’s unjust treatment of African Americans is a worldwide concern but impacts the African American community in different ways, particularly African American law enforcement officers who are placed in conflicting positions. They aspire to see change and more conforming police treatment, compared to other racial populations, but work for the same organization that exhibits the biased treatment they desire to have abolished. The purpose of this qualitative research study was to explore African American law enforcement officers’ experiences of conflicting identities. The theoretical foundation was based on Turner’s theory of self-categorization (SCT). The key research questions addressed African American …


Wicked Problems: Depression, Sebastian Wendolowski Nov 2020

Wicked Problems: Depression, Sebastian Wendolowski

English Department: Research for Change - Wicked Problems in Our World

Depression is a disorder that can affect anybody and is the leading cause of disability and disorders in the United States. This year, due to COVID-19, it has hit an all time high, affecting many more people. Suicide rates have been steadily growing across all ages, and this year is at a record high too, showing correlation with depression. There are two types of depression, major depressive disorder and chronic depressive disorder. Diagnosis of depression is typically done physically or through a questionnaire, which is compared into a DSM-5. There are many risk factors for depression and other common mental …


The History Of Lobotomies: Examining Its Impacts On Marginalized Groups And The Development Of Psychosurgery, Simon Godin, Brett Leblanc Feb 2020

The History Of Lobotomies: Examining Its Impacts On Marginalized Groups And The Development Of Psychosurgery, Simon Godin, Brett Leblanc

Psychology from the Margins

Frontal lobotomies, which are defined as the lesioning of the frontal lobe from the rest of the brain, were performed extensively from the 1930s to the 1960s in Europe and the United States, significantly impacting psychology and psychosurgery. The history of frontal lobotomies features many different practitioners with diverse methods; however, the overwhelming majority of popular lobotomists committed unethical actions by today’s standards that led to the direct marginalization of specific demographics. Using a framework guided by an exploration of those historically disempowered by the performance of lobotomies, this review article traces the lobotomy’s historical progression, focusing on the unethical …


The “Step-Child Of Scholarly Investigation”: Preliminary Observations About The Origins Of Academic Jewish Law Scholarship, David Hollander Jan 2020

The “Step-Child Of Scholarly Investigation”: Preliminary Observations About The Origins Of Academic Jewish Law Scholarship, David Hollander

Touro Law Review

No abstract provided.


‘Effective’ At What? On Effective Intervention In Serious Mental Illness, Susan Hawthorne, Anne Williams-Wengerd Mar 2019

‘Effective’ At What? On Effective Intervention In Serious Mental Illness, Susan Hawthorne, Anne Williams-Wengerd

Psychology Faculty Scholarship

The term “effective,” on its own, is honorific but vague. Interventions against serious mental illness may be “effective” at goals as diverse as reducing “apparent sadness” or providing housing. Underexamined use of “effective” and other success terms often obfuscates differences and incompatibilities in interventions, degrees of effectiveness, key omissions in effectiveness standards, and values involved in determining what counts as “effective.” Yet vague use of such success terms is common in the research, clinical, and policy realms, with consequences that negatively affect the care offered to individuals experiencing serious mental illness. A pragmatist-oriented solution to these problems suggests that when …


Lived Experiences Of Women Receiving Substance Abuse Treatment From Male Counselors, Robert C. Bennett Jan 2019

Lived Experiences Of Women Receiving Substance Abuse Treatment From Male Counselors, Robert C. Bennett

Walden Dissertations and Doctoral Studies

The cost of the misuse of drugs is significant. The impact is felt across multiple systems across America and is covered mostly by federal, state, and local governments. Women comprise a significant portion of the persons using illicit drugs. Treatment is an effective way of reducing substance misuse. However, research into the efficacy of treatment for women lag that of men. The Substance Abuse and Mental Health Services Administration reported that women receiving substance abuse treatment from a man had shorter stays in treatment and poorer outcomes than those who had a female counselor while in treatment. Phenomenological and relational-cultural …


Alzheimer's Disease Treatment Interventions And The Soul: Moral And Ethical Considerations, Bruce Vermeer May 2018

Alzheimer's Disease Treatment Interventions And The Soul: Moral And Ethical Considerations, Bruce Vermeer

Faculty Work Comprehensive List

No abstract provided.


Low Perceived Control Over Health Is Associated With Lower Treatment Uptake In A High Mortality Population Of Bolivian Forager-Farmers, Sarah Alami, Jonathan Stieglitz, Hillard Kaplan, Michael Gurven Jan 2018

Low Perceived Control Over Health Is Associated With Lower Treatment Uptake In A High Mortality Population Of Bolivian Forager-Farmers, Sarah Alami, Jonathan Stieglitz, Hillard Kaplan, Michael Gurven

ESI Publications

Indigenous people worldwide suffer from higher rates of morbidity and mortality than neighboring populations. In addition to having limited access to public health infrastructure, indigenous people may also have priorities and health perceptions that deter them from seeking adequate modern healthcare. Here we propose that living in a harsh and unpredictable environment reduces motivation to pursue deliberate, costly action to improve health outcomes. We assess whether variation in Health Locus of Control (HLC), a psychological construct designed to capture self-efficacy with respect to health, explains variation in treatment uptake behavior among Tsimane Amerindians (N=690; age range: 40–89 years; 55.8% female; …


“A Wound That Never Heals”: Health-Seeking Behaviors And Attitudes Towards Breast Cancer And Cancer In General Among Women In Nakirebe, Uganda, Ann Louise Tezak Jun 2016

“A Wound That Never Heals”: Health-Seeking Behaviors And Attitudes Towards Breast Cancer And Cancer In General Among Women In Nakirebe, Uganda, Ann Louise Tezak

USF Tampa Graduate Theses and Dissertations

The scale and severity of cancer, specifically breast cancer, remains significantly different across the spectrum of low-income to high-income countries. This study explores women’s beliefs about breast cancer and associated prevention and health-seeking behaviors in a rural area of Uganda. Through a critical medical anthropological perspective, the study examines the social, cultural, and economic factors that shape women’s understanding of cancer, and breast cancer specifically, and that influence their use of biomedical services. Data were collected over a three-month period through 35 in-depth interviews and two focus groups with 10 women older than 18 years in the rural setting of …


An Examination Of The Relationship Between Authenticity And Female Sexual Dysfunction, Ellen Kaye Smith Jan 2016

An Examination Of The Relationship Between Authenticity And Female Sexual Dysfunction, Ellen Kaye Smith

Walden Dissertations and Doctoral Studies

Since the late 1990s, researchers have reported a high degree of sexual dysfunction among American women that is associated with significant negative consequences (e.g., reduced quality of life and sexual satisfaction). In addition, sexual satisfaction is a primary factor in marital stability. Because of the widespread impact on both individual well-being and marital relationships, female sexual dysfunction is a significant public health problem. Most research has supported the predominance of psychocultural factors in women's sexual issues. Authenticity, defined by Kernis and Goldman as acting in accord with one's natural inclinations, is associated with increased well-being, but researchers have often overlooked …


Cancer Treatment During Martha Mcmillan's Time (1913), Taylor L. Stephens Apr 2015

Cancer Treatment During Martha Mcmillan's Time (1913), Taylor L. Stephens

Martha McMillan Research Papers

No abstract provided.


Practical Application Of Emotional Freedom Techniques For Food Cravings, Peta Stapleton, Terri Sheldon, Brett Porter Aug 2013

Practical Application Of Emotional Freedom Techniques For Food Cravings, Peta Stapleton, Terri Sheldon, Brett Porter

Peta B. Stapleton

Emotional Freedom Techniques (EFT) has been shown to have a lasting effect on food cravings, power over food and restraint ability, and ultimately results in weight loss. This paper discusses the approach utilised in a recent food craving clinical treatment trial (Stapleton, Sheldon, & Porter, 2012; Stapleton, Sheldon, Porter, & Whitty, 2011), and highlights the case of a single participant. Sessions are described in detail and specific recommendations are made for the application of EFT to food cravings in overweight and obese individuals.


Predicting Dropout In The First 3 Months Of 12-Step Residential Drug And Alcohol Treatment In An Australian Sample, Frank P. Deane, David J. Wootton, Ching-I Hsu, Peter J. Kelly Jul 2013

Predicting Dropout In The First 3 Months Of 12-Step Residential Drug And Alcohol Treatment In An Australian Sample, Frank P. Deane, David J. Wootton, Ching-I Hsu, Peter J. Kelly

Peter Kelly

Objective: Premature termination from treatment is a major factor associated with poorer drug and alcohol treatment outcomes. The present study investigated client-related baseline predictors of dropout at 3 months from a faith-based 12-step residential drug treatment program. Method: Data were collected over a period of 14 months from eight residential drug and alcohol treatment programs run by The Australian Salvation Army. The final sample consisted of 618 participants, including 524 men (84.8%) and 94 women (15.2%). Predictor variables of interest were age, gender, primary drug of concern, criminal involvement, psychological distress, drug cravings, self-efficacy to abstain, spirituality, forgiveness of self …


Clinically Signficant Change To Establish Benchmarks In Residential Drug And Alcohol Treatment Services, Daniel Billingham, Peter Kelly, Frank Deane, Trevor Crowe, Mark Buckingham, Fiona Craig Jul 2013

Clinically Signficant Change To Establish Benchmarks In Residential Drug And Alcohol Treatment Services, Daniel Billingham, Peter Kelly, Frank Deane, Trevor Crowe, Mark Buckingham, Fiona Craig

Peter Kelly

There is increasing emphasis on the use routine outcome assessment measures to inform quality assurance initiatives. The calculation of reliable and clinically significant change indices is one strategy that organizations could use to develop both internal and externally focused benchmarking processes. The current study aimed to develop reliable and clinically significant change indices for a range of commonly used outcome measures in the substance abuse field. Participants were attending Kedesh Rehabilitation Services, an Australian residential substance abuse service that also accepts people with co-occurring mental health problems (n0595). A range of mental health and substance use measures were administered to …


A Comparison Of Treatment Outcomes For Individuals With Substance Use Disorder Alone And Individuals With Probable Dual Diagnosis, Elizabeth K. Cridland, Frank P. Deane, Ching-I Hsu, Peter J. Kelly Jul 2013

A Comparison Of Treatment Outcomes For Individuals With Substance Use Disorder Alone And Individuals With Probable Dual Diagnosis, Elizabeth K. Cridland, Frank P. Deane, Ching-I Hsu, Peter J. Kelly

Peter Kelly

The co-occurrence of substance use and mental health problems, often referred to as dual diagnosis (DD), is increasingly recognised as commonplace within substance abuse treatment programs. Two-hundred and thirty-four individuals from 9 Australian Salvation Army drug and alcohol rehabilitation programs completed a 3-month post-discharge telephone follow-up. Using a cut-off score from the Psychiatric Subscale of the Addiction Severity Index (5th ed.), 66.7% were classified as likely to have DD and 33.3% as substance use disorder only (SUD). Both groups reported comparable and decreased substance use levels at follow-up, yet DD individuals perceived less improvement in substance use problems. Comparable improvements …


Prevalence Of Smoking And Other Health Risk Factors In People Attending Residential Substance Abuse Treatment, Peter J. Kelly, Amanda L. Baker, Frank P. Deane, Frances Kay-Lambkin, Billie Bonevski, Jenna Tregarthen Jul 2013

Prevalence Of Smoking And Other Health Risk Factors In People Attending Residential Substance Abuse Treatment, Peter J. Kelly, Amanda L. Baker, Frank P. Deane, Frances Kay-Lambkin, Billie Bonevski, Jenna Tregarthen

Peter Kelly

Introduction and Aims. People attending substance abuse treatment have an elevated risk of developing cardiovascular disease (CVD) and cancer. Consequently, there have been increasing calls for substance abuse treatment services to address smoking.The current study examined smoking behaviours of people attending residential substance abuse treatment. Additionally, the study examined rates of other potentially modifiable health risk factors for the development of CVD and cancer. Design and Methods. A cross-sectional survey was completed by participants attending Australian Salvation Army residential substance abuse treatment services (n = 228). Rates of smoking, exercise, dietary fat intake, body mass index and depression were identified …


Study Protocol: A Randomized Controlled Trial Of A Computer-Based Depression And Substance Abuse Intervention For People Attending Residential Substance Abuse Treatment, Peter J. Kelly, Frances Kay-Lambkin, Amanda Baker, Frank P. Deane, Adam C. Brooks, Alexandra Mitchell, Sarah Marshall, Meredith Whittington, Genevieve A. Dingle Jul 2013

Study Protocol: A Randomized Controlled Trial Of A Computer-Based Depression And Substance Abuse Intervention For People Attending Residential Substance Abuse Treatment, Peter J. Kelly, Frances Kay-Lambkin, Amanda Baker, Frank P. Deane, Adam C. Brooks, Alexandra Mitchell, Sarah Marshall, Meredith Whittington, Genevieve A. Dingle

Peter Kelly

"Background: A large proportion of people attending residential alcohol and other substance abuse treatment have a co-occurring mental illness. Empirical evidence suggests that it is important to treat both the substance abuse problem and co-occurring mental illness concurrently and in an integrated fashion. However, the majority of residential alcohol and other substance abuse services do not address mental illness in a systematic way. It is likely that computer delivered interventions could improve the ability of substance abuse services to address co-occurring mental illness. This protocol describes a study in which we will assess the effectiveness of adding a computer delivered …


Olanzapine Treatment And Time-Dependent Changes Of Hypothalamic Ampk-Acc-Cpt1 Signalling, Food Intake And Body Weight In Rats, Meng He, Q Zhang, H Wang, Jiamei Lian, C Deng, Xu-Feng Huang Apr 2013

Olanzapine Treatment And Time-Dependent Changes Of Hypothalamic Ampk-Acc-Cpt1 Signalling, Food Intake And Body Weight In Rats, Meng He, Q Zhang, H Wang, Jiamei Lian, C Deng, Xu-Feng Huang

Xu-Feng Huang

No abstract provided.


Predicting Dropout In The First 3 Months Of 12-Step Residential Drug And Alcohol Treatment In An Australian Sample, Frank P. Deane, David J. Wootton, Ching-I Hsu, Peter J. Kelly Dec 2012

Predicting Dropout In The First 3 Months Of 12-Step Residential Drug And Alcohol Treatment In An Australian Sample, Frank P. Deane, David J. Wootton, Ching-I Hsu, Peter J. Kelly

Frank Deane

Objective: Premature termination from treatment is a major factor associated with poorer drug and alcohol treatment outcomes. The present study investigated client-related baseline predictors of dropout at 3 months from a faith-based 12-step residential drug treatment program. Method: Data were collected over a period of 14 months from eight residential drug and alcohol treatment programs run by The Australian Salvation Army. The final sample consisted of 618 participants, including 524 men (84.8%) and 94 women (15.2%). Predictor variables of interest were age, gender, primary drug of concern, criminal involvement, psychological distress, drug cravings, self-efficacy to abstain, spirituality, forgiveness of self …


Prevalence Of Smoking And Other Health Risk Factors In People Attending Residential Substance Abuse Treatment, Peter J. Kelly, Amanda L. Baker, Frank P. Deane, Frances Kay-Lambkin, Billie Bonevski, Jenna Tregarthen Dec 2012

Prevalence Of Smoking And Other Health Risk Factors In People Attending Residential Substance Abuse Treatment, Peter J. Kelly, Amanda L. Baker, Frank P. Deane, Frances Kay-Lambkin, Billie Bonevski, Jenna Tregarthen

Frank Deane

Introduction and Aims. People attending substance abuse treatment have an elevated risk of developing cardiovascular disease (CVD) and cancer. Consequently, there have been increasing calls for substance abuse treatment services to address smoking.The current study examined smoking behaviours of people attending residential substance abuse treatment. Additionally, the study examined rates of other potentially modifiable health risk factors for the development of CVD and cancer. Design and Methods. A cross-sectional survey was completed by participants attending Australian Salvation Army residential substance abuse treatment services (n = 228). Rates of smoking, exercise, dietary fat intake, body mass index and depression were identified …


A Comparison Of Treatment Outcomes For Individuals With Substance Use Disorder Alone And Individuals With Probable Dual Diagnosis, Elizabeth K. Cridland, Frank P. Deane, Ching-I Hsu, Peter J. Kelly Dec 2012

A Comparison Of Treatment Outcomes For Individuals With Substance Use Disorder Alone And Individuals With Probable Dual Diagnosis, Elizabeth K. Cridland, Frank P. Deane, Ching-I Hsu, Peter J. Kelly

Frank Deane

The co-occurrence of substance use and mental health problems, often referred to as dual diagnosis (DD), is increasingly recognised as commonplace within substance abuse treatment programs. Two-hundred and thirty-four individuals from 9 Australian Salvation Army drug and alcohol rehabilitation programs completed a 3-month post-discharge telephone follow-up. Using a cut-off score from the Psychiatric Subscale of the Addiction Severity Index (5th ed.), 66.7% were classified as likely to have DD and 33.3% as substance use disorder only (SUD). Both groups reported comparable and decreased substance use levels at follow-up, yet DD individuals perceived less improvement in substance use problems. Comparable improvements …


Using The Theory Of Planned Behavior And Barriers To Treatment To Predict Intention To Enter Further Treatment Following Residential Drug And Alcohol Detoxification: A Pilot Study, Peter J. Kelly, Frank P. Deane, Zoe Mccarthy, Trevor P. Crowe Nov 2012

Using The Theory Of Planned Behavior And Barriers To Treatment To Predict Intention To Enter Further Treatment Following Residential Drug And Alcohol Detoxification: A Pilot Study, Peter J. Kelly, Frank P. Deane, Zoe Mccarthy, Trevor P. Crowe

Trevor Crowe

There has been limited research examining the impact of clients’ behavioural beliefs on whether they intend to access further treatment following residential drug and alcohol detoxification. Treatment post-detoxification is generally recommended to reduce relapse and for more sustained positive outcomes. The present pilot study examined the extent to which (1) primary components of the Theory of Planned Behaviour (TPB), (2) perceived barriers to accessing treatment and (3) the participants’ previous involvement in substance abuse treatment predicted intentions to enter further treatment following residential detoxification. One hundred and sixty eight participants accessing Salvation Army detoxification units in Australia completed a survey …


Nurse's Beliefs And Knowledge About Medications Are Associated With Their Difficulties Using Patient Treatment Adherence Strategies, Mitchell Byrne, Frank Deane, Tim Coombs Nov 2012

Nurse's Beliefs And Knowledge About Medications Are Associated With Their Difficulties Using Patient Treatment Adherence Strategies, Mitchell Byrne, Frank Deane, Tim Coombs

Mitchell K Byrne

Background: The attitudes and beliefs of patients toward their treatment have been found to be an important factor in treatment outcome, particularly as it relates to treatment adherence. There are also suggestions that knowledge, attitudes and beliefs held by nurses about treatments may also be important influences on treatment outcome but there has been little research relating these to specific clinical behaviour. Aims: This study explored the knowledge and beliefs of nurses toward neuroleptic medications in the treatment of severe mental ill health with the view to identifying specific nurse training needs. Method: A convenience sample of 64 nurses was …


Study Protocol: A Randomized Controlled Trial Of A Computer-Based Depression And Substance Abuse Intervention For People Attending Residential Substance Abuse Treatment, Peter J. Kelly, Frances Kay-Lambkin, Amanda Baker, Frank P. Deane, Adam C. Brooks, Alexandra Mitchell, Sarah Marshall, Meredith Whittington, Genevieve A. Dingle Oct 2012

Study Protocol: A Randomized Controlled Trial Of A Computer-Based Depression And Substance Abuse Intervention For People Attending Residential Substance Abuse Treatment, Peter J. Kelly, Frances Kay-Lambkin, Amanda Baker, Frank P. Deane, Adam C. Brooks, Alexandra Mitchell, Sarah Marshall, Meredith Whittington, Genevieve A. Dingle

Frank Deane

"Background: A large proportion of people attending residential alcohol and other substance abuse treatment have a co-occurring mental illness. Empirical evidence suggests that it is important to treat both the substance abuse problem and co-occurring mental illness concurrently and in an integrated fashion. However, the majority of residential alcohol and other substance abuse services do not address mental illness in a systematic way. It is likely that computer delivered interventions could improve the ability of substance abuse services to address co-occurring mental illness. This protocol describes a study in which we will assess the effectiveness of adding a computer delivered …


Short- And Long-Term Effects Of Antipsychotic Drug Treatment On Weight Gain And H1 Receptor Expression, Kelly Newell, Xu-Feng Huang, Chao Deng, Tom Burne, Mei Han Sep 2012

Short- And Long-Term Effects Of Antipsychotic Drug Treatment On Weight Gain And H1 Receptor Expression, Kelly Newell, Xu-Feng Huang, Chao Deng, Tom Burne, Mei Han

Xu-Feng Huang

The present study investigated body weight gain, food intake, open-field activity and brain histamine H1 receptor mRNA and protein expression in rats treated with three types of antipsychotics. Rats were divided into eight groups and treated with aripiprazole (2.25mg/kg/day), olanzapine (1.5mg/kg/day), haloperidol (0.3mg/kg/day) or vehicle (as control) for 1 or 12 weeks. Administration of olanzapine for 1 week led to a threefold increase in body weight gain and a 35% increase in fat deposits compared to controls (p<0.05). In the 12-week olanzapine treatment group, accumulative food intake was significantly higher in the first 7 weeks of treatment compared to …


Effect Of Chronic Treatment With Clozapine And Haloperidol On 5- Ht2a And 2c Receptor Mrna Expression In The Rat Brain, Xu-Feng Huang, Qing Wang, Yean Yeow Tan Sep 2012

Effect Of Chronic Treatment With Clozapine And Haloperidol On 5- Ht2a And 2c Receptor Mrna Expression In The Rat Brain, Xu-Feng Huang, Qing Wang, Yean Yeow Tan

Xu-Feng Huang

No abstract provided.


Chronic Treatment With Simvastatin Upregulates Muscarinic M1/4 Receptor Binding In The Rat Brain, Kelly Newell, P Wong, Xu-Feng Huang, Qing Wang, Wilfred Yeo, P Wang, Weihai Ying, Midori Yenari, Ayse Zengin Sep 2012

Chronic Treatment With Simvastatin Upregulates Muscarinic M1/4 Receptor Binding In The Rat Brain, Kelly Newell, P Wong, Xu-Feng Huang, Qing Wang, Wilfred Yeo, P Wang, Weihai Ying, Midori Yenari, Ayse Zengin

Xu-Feng Huang

Statins are increasingly being used for the treatment of a variety of conditions beyond their original indication for cholesterol lowering. We previously reported that simvastatin affected the dopaminergic system in the rat brain. This study aims to investigate regional changes of muscarinic M1/4 receptors in the rat brain after 4-week administration of simvastatin (1 or 10 mg/kg/day). M1/4 receptor distribution and alterations in the post-mortem rat brain were detected by [3H]pirenzepine binding autoradiography. Simvastatin (1 mg/kg/day) increased [3H]pirenzepine binding, predominantly in the prefrontal cortex (171%, P<0.001), primary motor cortex (153%, P=0.001), cingulate cortex (109%, P<0.001), hippocampus (138%, P …