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Articles 1 - 30 of 60
Full-Text Articles in Arts and Humanities
All Clear: A Workbook For Sexually Active Accutane Users Who Can Become Pregnant, Taylor Petersen
All Clear: A Workbook For Sexually Active Accutane Users Who Can Become Pregnant, Taylor Petersen
Honors Projects
Accutane is a pill-based derivative of Vitamin A used to treat cystic acne. The process to start and continue the medication each month is tedious and full of potential for error. This is especially true for female patients who are able to become pregnant as they have the additional step of monitoring and updating their birth control through an online portal. Patients are treated like numbers and there is little to no customization within Accutane treatment from patient to patient. To make this worse, reliable information about the drug is scarce and many turn to social media platforms or other …
Review Of Alcohol And Drug Treatment For Aboriginal And Torres Strait Islander Peoples, Marguerite Tracy, Bradley Freeburn, Kylie Lee, Julie Woods, Kate Conigrave
Review Of Alcohol And Drug Treatment For Aboriginal And Torres Strait Islander Peoples, Marguerite Tracy, Bradley Freeburn, Kylie Lee, Julie Woods, Kate Conigrave
Journal of the Australian Indigenous HealthInfoNet
This review provides an overview of treatments for problem alcohol and other drug (AOD) use for Aboriginal and Torres Strait Islander people. It includes information on the available research and discusses core principles for providing treatment. The review outlines how effective mainstream treatment approaches can be adapted to be more suitable for Aboriginal and Torres Strait Islander ways of being or worldview. It also highlights that services, such as those offered by Aboriginal community controlled health organisations are in a unique position to offer culturally secure treatment approaches. The barriers to accessing treatment are discussed as well as recommendations for …
A Scoping Review Of Alcohol, Tobacco, And Other Drug Use Treatment Interventions For Sexual And Gender Minority Populations, Jeremy D. Kidd, Margaret M. Paschen-Wolff, Amy A. Mericle, Billy A. Caceres, Laurie A. Drabble, Tonda L. Hughes
A Scoping Review Of Alcohol, Tobacco, And Other Drug Use Treatment Interventions For Sexual And Gender Minority Populations, Jeremy D. Kidd, Margaret M. Paschen-Wolff, Amy A. Mericle, Billy A. Caceres, Laurie A. Drabble, Tonda L. Hughes
Faculty Research, Scholarly, and Creative Activity
Background
Alcohol, tobacco, and other drug use are among the most prevalent and important health disparities affecting sexual and gender minority (SGM; e.g., lesbian, gay, bisexual, transgender) populations. Although numerous government agencies and health experts have called for substance use intervention studies to address these disparities, such studies continue to be relatively rare.
Method
We conducted a scoping review of prevention and drug treatment intervention studies for alcohol, tobacco, and other drug use that were conducted with SGM adults. We searched three databases to identify pertinent English-language, peer-reviewed articles published between 1985 and 2019.
Results
Our search yielded 71 articles. …
Experiences Of Women In Sierra Leone Relating To Accessing Breast Cancer Treatment, Anne Neville
Experiences Of Women In Sierra Leone Relating To Accessing Breast Cancer Treatment, Anne Neville
Walden Dissertations and Doctoral Studies
There has been a lack of consistent access to breast cancer care and treatment for women in developing countries, especially in Sierra Leone. Limited access to breast cancer care and treatment is a significant problem for women diagnosed in the later stages of the disease. The purpose of this research was to understand the experiences of women diagnosed with different stages of breast cancer, how they went about accessing breast cancer care and treatment, and how those experiences can be used to improve access to breast cancer treatment in Sierra Leone. Andersen and Newman’s healthcare utilization model guided the study’s …
Wicked Problems: Depression, Sebastian Wendolowski
Wicked Problems: Depression, Sebastian Wendolowski
English Department: Research for Change - Wicked Problems in Our World
Depression is a disorder that can affect anybody and is the leading cause of disability and disorders in the United States. This year, due to COVID-19, it has hit an all time high, affecting many more people. Suicide rates have been steadily growing across all ages, and this year is at a record high too, showing correlation with depression. There are two types of depression, major depressive disorder and chronic depressive disorder. Diagnosis of depression is typically done physically or through a questionnaire, which is compared into a DSM-5. There are many risk factors for depression and other common mental …
The History Of Lobotomies: Examining Its Impacts On Marginalized Groups And The Development Of Psychosurgery, Simon Godin, Brett Leblanc
The History Of Lobotomies: Examining Its Impacts On Marginalized Groups And The Development Of Psychosurgery, Simon Godin, Brett Leblanc
Psychology from the Margins
Frontal lobotomies, which are defined as the lesioning of the frontal lobe from the rest of the brain, were performed extensively from the 1930s to the 1960s in Europe and the United States, significantly impacting psychology and psychosurgery. The history of frontal lobotomies features many different practitioners with diverse methods; however, the overwhelming majority of popular lobotomists committed unethical actions by today’s standards that led to the direct marginalization of specific demographics. Using a framework guided by an exploration of those historically disempowered by the performance of lobotomies, this review article traces the lobotomy’s historical progression, focusing on the unethical …
Immunotherapy: Therapy Vs. Enhancement, Mariah Daly
Immunotherapy: Therapy Vs. Enhancement, Mariah Daly
Honors Program Theses
The battle against cancer is a long-standing struggle that has resulted in new information and the development of novel medical technologies. Current research aims to figure out a way to reprogram cells and bodily mechanisms to eliminate those cells that are cancerous without destroying healthy cells in the process. Methods which use the body’s own mechanisms, such as immunotherapy, have shown and continue to show potential for specifically targeting cancer cells. Adoptive T cell therapy is one form of immunotherapy that has gained significant attention and focus in the field. Therapies improve conditions up to the normal state of being, …
El Vph Y El Cáncer Cervical En El Perú: Diferencias De Accesibilidad Entre Las Mujeres De Las Zonas Rurales Y Urbanas / Hpv And Cervical Cancer In Peru: The Differences In Accessibility For Rural And Urban Women, Jemma Stratton
James Madison Undergraduate Research Journal (JMURJ)
Este informe examina el estado actual del tratamiento y prevención del VPH en el Perú, y pone énfasis con problemas específicas que han contribuido al riesgo alto de cáncer cervical entre las mujeres rurales. Perú ha tomado grandes pasos en las décadas últimas para establecer programas que se dirigen al VPH y la salud de las mujeres. Sin embargo, las mujeres peruanas tienen una población más probable para contraer cáncer cervical en el mundo. Este informe compara los esfuerzos de prevención del VPH entre las poblaciones rurales y urbanas en el Perú y identificar las barreras que causando esta crisis …
‘Effective’ At What? On Effective Intervention In Serious Mental Illness, Susan Hawthorne, Anne Williams-Wengerd
‘Effective’ At What? On Effective Intervention In Serious Mental Illness, Susan Hawthorne, Anne Williams-Wengerd
Psychology Faculty Scholarship
The term “effective,” on its own, is honorific but vague. Interventions against serious mental illness may be “effective” at goals as diverse as reducing “apparent sadness” or providing housing. Underexamined use of “effective” and other success terms often obfuscates differences and incompatibilities in interventions, degrees of effectiveness, key omissions in effectiveness standards, and values involved in determining what counts as “effective.” Yet vague use of such success terms is common in the research, clinical, and policy realms, with consequences that negatively affect the care offered to individuals experiencing serious mental illness. A pragmatist-oriented solution to these problems suggests that when …
“A Wound That Never Heals”: Health-Seeking Behaviors And Attitudes Towards Breast Cancer And Cancer In General Among Women In Nakirebe, Uganda, Ann Louise Tezak
“A Wound That Never Heals”: Health-Seeking Behaviors And Attitudes Towards Breast Cancer And Cancer In General Among Women In Nakirebe, Uganda, Ann Louise Tezak
USF Tampa Graduate Theses and Dissertations
The scale and severity of cancer, specifically breast cancer, remains significantly different across the spectrum of low-income to high-income countries. This study explores women’s beliefs about breast cancer and associated prevention and health-seeking behaviors in a rural area of Uganda. Through a critical medical anthropological perspective, the study examines the social, cultural, and economic factors that shape women’s understanding of cancer, and breast cancer specifically, and that influence their use of biomedical services. Data were collected over a three-month period through 35 in-depth interviews and two focus groups with 10 women older than 18 years in the rural setting of …
The Medical Response To The Black Death, Joseph A. Legan
The Medical Response To The Black Death, Joseph A. Legan
Senior Honors Projects, 2010-2019
This paper discusses the medical response to the Black Death in both Europe and the Middle East. The Black Death was caused by a series of bacterial strands collectively known as Yersinia pestis. The Plague originated in the Mongolian Steppes. It was spread westward by the east-west trading system. Once it arrived in the Crimea in 1346, Italian merchants helped spread it throughout the Mediterranean. Medicine in Europe and the Middle East were centered on Galen’s theory of humors. There were many religious explanations for the Plague, but the main medical explanation was the spread of bad air, or …
Cancer Treatment During Martha Mcmillan's Time (1913), Taylor L. Stephens
Cancer Treatment During Martha Mcmillan's Time (1913), Taylor L. Stephens
Martha McMillan Research Papers
No abstract provided.
Women's Perspectives On Adequacy Of Screening And Treatment For Postpartum Depression, Gloria Marcia Watson
Women's Perspectives On Adequacy Of Screening And Treatment For Postpartum Depression, Gloria Marcia Watson
Walden Dissertations and Doctoral Studies
Postpartum depression affects some 10% to 20% of mothers. Its impact on the health and well-being of mothers and their infants is well documented. If not identified and addressed early, it can result in emotional burden, costly hospitalization and treatment, and, at worst, suicide and or infanticide. Empowerment theory was the conceptual framework for this hermeneutic phenomenological study. The purpose was to understand the lived experiences of the screening and treatment processes of 10 women from New York City experiencing postpartum depression and their perceived adequacy of the treatment received. In-depth interviews were used to investigate participants' lived experiences of …
The Search For A Coherent Language: The Science And Politics Of Drug Testing And Approval, Jason Karlawish
The Search For A Coherent Language: The Science And Politics Of Drug Testing And Approval, Jason Karlawish
Jason Karlawish
No abstract provided.
An Exploration Of The Relationship Between Religiousness And Treatment Seeking Trends Among College Students, Jessica M. Sturgeon
An Exploration Of The Relationship Between Religiousness And Treatment Seeking Trends Among College Students, Jessica M. Sturgeon
Honors Program Projects
The purpose of this study was to determine if there is a relationship between levels of religiousness and students’ openness to seeking treatment for mental health disorders in college‐aged students at a small private university. A total of 141 complete surveys were collected from students. Each participant completed the Fetzer Multidimensional Measurement of Religiousness/Spirituality for Use in Health Research along with an eight‐question survey assessing willingness to seek treatment for mental disorders. The results were analyzed to find the Spearman’s Rank Correlation Coefficient to determine correlation. Results show a significant correlation between levels of religiousness and willingness to seek treatment …
De Concentv Amisso Qvaerendo: An Investigation Into The Relative Benefits Of Three Different Types Of Ambient Music On The Observed Agitated Behaviour And Quality Of Life Of Dementia Sufferers In Residential Aged Care Facilities, Peter Wilkinson
Theses: Doctorates and Masters
There is an increasing body of research evidence to support the use of music as a therapeutic modality in reducing the agitated behaviour frequently associated with late-stage dementia. Although much of this evidence suggests that music interventions are most effective when they are “individualized”, this type of intervention is often difficult to implement in large, busy, aged care facilities where residents may be located together in communal areas during the day. The challenge therefore is to try and identify a particular musical genre which, when played as “ambient” or “background” music, demonstrates a consistent capacity to reduce agitated behaviour in …
Which Stressors Are Associated With Which Forms Of Depression In A Homogenous Sample? An Analysis Of The Effects Of Lifestyle Changes And Demands On Five Subtypes Of Depression, Vicki Bitsika, Christopher Sharpley
Which Stressors Are Associated With Which Forms Of Depression In A Homogenous Sample? An Analysis Of The Effects Of Lifestyle Changes And Demands On Five Subtypes Of Depression, Vicki Bitsika, Christopher Sharpley
Vicki Bitsika
Background: Although depression is often considered as a single or unitary construct, evidence indicates the existence of several major subtypes of depression, some of which have distinct neurobiological bases and treatment options. Objective: To explore the incidence of five subtypes of depression, and to identify which lifestyle changes and stressor demands are associated with each of five established subtypes of depression, within a homogenous non-clinical sample. Method: 398 Australian university students completed the Effects of University Study on Lifestyle Questionnaire to identify their major stressors, plus the Zung Self-Rating Depression Scale to measure their symptomatology. Regression analysis was used to …
Predicting Dropout In The First 3 Months Of 12-Step Residential Drug And Alcohol Treatment In An Australian Sample, Frank P. Deane, David J. Wootton, Ching-I Hsu, Peter J. Kelly
Predicting Dropout In The First 3 Months Of 12-Step Residential Drug And Alcohol Treatment In An Australian Sample, Frank P. Deane, David J. Wootton, Ching-I Hsu, Peter J. Kelly
Peter Kelly
Objective: Premature termination from treatment is a major factor associated with poorer drug and alcohol treatment outcomes. The present study investigated client-related baseline predictors of dropout at 3 months from a faith-based 12-step residential drug treatment program. Method: Data were collected over a period of 14 months from eight residential drug and alcohol treatment programs run by The Australian Salvation Army. The final sample consisted of 618 participants, including 524 men (84.8%) and 94 women (15.2%). Predictor variables of interest were age, gender, primary drug of concern, criminal involvement, psychological distress, drug cravings, self-efficacy to abstain, spirituality, forgiveness of self …
Clinically Signficant Change To Establish Benchmarks In Residential Drug And Alcohol Treatment Services, Daniel Billingham, Peter Kelly, Frank Deane, Trevor Crowe, Mark Buckingham, Fiona Craig
Clinically Signficant Change To Establish Benchmarks In Residential Drug And Alcohol Treatment Services, Daniel Billingham, Peter Kelly, Frank Deane, Trevor Crowe, Mark Buckingham, Fiona Craig
Peter Kelly
There is increasing emphasis on the use routine outcome assessment measures to inform quality assurance initiatives. The calculation of reliable and clinically significant change indices is one strategy that organizations could use to develop both internal and externally focused benchmarking processes. The current study aimed to develop reliable and clinically significant change indices for a range of commonly used outcome measures in the substance abuse field. Participants were attending Kedesh Rehabilitation Services, an Australian residential substance abuse service that also accepts people with co-occurring mental health problems (n0595). A range of mental health and substance use measures were administered to …
A Comparison Of Treatment Outcomes For Individuals With Substance Use Disorder Alone And Individuals With Probable Dual Diagnosis, Elizabeth K. Cridland, Frank P. Deane, Ching-I Hsu, Peter J. Kelly
A Comparison Of Treatment Outcomes For Individuals With Substance Use Disorder Alone And Individuals With Probable Dual Diagnosis, Elizabeth K. Cridland, Frank P. Deane, Ching-I Hsu, Peter J. Kelly
Peter Kelly
The co-occurrence of substance use and mental health problems, often referred to as dual diagnosis (DD), is increasingly recognised as commonplace within substance abuse treatment programs. Two-hundred and thirty-four individuals from 9 Australian Salvation Army drug and alcohol rehabilitation programs completed a 3-month post-discharge telephone follow-up. Using a cut-off score from the Psychiatric Subscale of the Addiction Severity Index (5th ed.), 66.7% were classified as likely to have DD and 33.3% as substance use disorder only (SUD). Both groups reported comparable and decreased substance use levels at follow-up, yet DD individuals perceived less improvement in substance use problems. Comparable improvements …
Prevalence Of Smoking And Other Health Risk Factors In People Attending Residential Substance Abuse Treatment, Peter J. Kelly, Amanda L. Baker, Frank P. Deane, Frances Kay-Lambkin, Billie Bonevski, Jenna Tregarthen
Prevalence Of Smoking And Other Health Risk Factors In People Attending Residential Substance Abuse Treatment, Peter J. Kelly, Amanda L. Baker, Frank P. Deane, Frances Kay-Lambkin, Billie Bonevski, Jenna Tregarthen
Peter Kelly
Introduction and Aims. People attending substance abuse treatment have an elevated risk of developing cardiovascular disease (CVD) and cancer. Consequently, there have been increasing calls for substance abuse treatment services to address smoking.The current study examined smoking behaviours of people attending residential substance abuse treatment. Additionally, the study examined rates of other potentially modifiable health risk factors for the development of CVD and cancer. Design and Methods. A cross-sectional survey was completed by participants attending Australian Salvation Army residential substance abuse treatment services (n = 228). Rates of smoking, exercise, dietary fat intake, body mass index and depression were identified …
Study Protocol: A Randomized Controlled Trial Of A Computer-Based Depression And Substance Abuse Intervention For People Attending Residential Substance Abuse Treatment, Peter J. Kelly, Frances Kay-Lambkin, Amanda Baker, Frank P. Deane, Adam C. Brooks, Alexandra Mitchell, Sarah Marshall, Meredith Whittington, Genevieve A. Dingle
Study Protocol: A Randomized Controlled Trial Of A Computer-Based Depression And Substance Abuse Intervention For People Attending Residential Substance Abuse Treatment, Peter J. Kelly, Frances Kay-Lambkin, Amanda Baker, Frank P. Deane, Adam C. Brooks, Alexandra Mitchell, Sarah Marshall, Meredith Whittington, Genevieve A. Dingle
Peter Kelly
"Background: A large proportion of people attending residential alcohol and other substance abuse treatment have a co-occurring mental illness. Empirical evidence suggests that it is important to treat both the substance abuse problem and co-occurring mental illness concurrently and in an integrated fashion. However, the majority of residential alcohol and other substance abuse services do not address mental illness in a systematic way. It is likely that computer delivered interventions could improve the ability of substance abuse services to address co-occurring mental illness. This protocol describes a study in which we will assess the effectiveness of adding a computer delivered …
Olanzapine Treatment And Time-Dependent Changes Of Hypothalamic Ampk-Acc-Cpt1 Signalling, Food Intake And Body Weight In Rats, Meng He, Q Zhang, H Wang, Jiamei Lian, C Deng, Xu-Feng Huang
Olanzapine Treatment And Time-Dependent Changes Of Hypothalamic Ampk-Acc-Cpt1 Signalling, Food Intake And Body Weight In Rats, Meng He, Q Zhang, H Wang, Jiamei Lian, C Deng, Xu-Feng Huang
Xu-Feng Huang
No abstract provided.
Predicting Dropout In The First 3 Months Of 12-Step Residential Drug And Alcohol Treatment In An Australian Sample, Frank P. Deane, David J. Wootton, Ching-I Hsu, Peter J. Kelly
Predicting Dropout In The First 3 Months Of 12-Step Residential Drug And Alcohol Treatment In An Australian Sample, Frank P. Deane, David J. Wootton, Ching-I Hsu, Peter J. Kelly
Frank Deane
Objective: Premature termination from treatment is a major factor associated with poorer drug and alcohol treatment outcomes. The present study investigated client-related baseline predictors of dropout at 3 months from a faith-based 12-step residential drug treatment program. Method: Data were collected over a period of 14 months from eight residential drug and alcohol treatment programs run by The Australian Salvation Army. The final sample consisted of 618 participants, including 524 men (84.8%) and 94 women (15.2%). Predictor variables of interest were age, gender, primary drug of concern, criminal involvement, psychological distress, drug cravings, self-efficacy to abstain, spirituality, forgiveness of self …
Prevalence Of Smoking And Other Health Risk Factors In People Attending Residential Substance Abuse Treatment, Peter J. Kelly, Amanda L. Baker, Frank P. Deane, Frances Kay-Lambkin, Billie Bonevski, Jenna Tregarthen
Prevalence Of Smoking And Other Health Risk Factors In People Attending Residential Substance Abuse Treatment, Peter J. Kelly, Amanda L. Baker, Frank P. Deane, Frances Kay-Lambkin, Billie Bonevski, Jenna Tregarthen
Frank Deane
Introduction and Aims. People attending substance abuse treatment have an elevated risk of developing cardiovascular disease (CVD) and cancer. Consequently, there have been increasing calls for substance abuse treatment services to address smoking.The current study examined smoking behaviours of people attending residential substance abuse treatment. Additionally, the study examined rates of other potentially modifiable health risk factors for the development of CVD and cancer. Design and Methods. A cross-sectional survey was completed by participants attending Australian Salvation Army residential substance abuse treatment services (n = 228). Rates of smoking, exercise, dietary fat intake, body mass index and depression were identified …
A Comparison Of Treatment Outcomes For Individuals With Substance Use Disorder Alone And Individuals With Probable Dual Diagnosis, Elizabeth K. Cridland, Frank P. Deane, Ching-I Hsu, Peter J. Kelly
A Comparison Of Treatment Outcomes For Individuals With Substance Use Disorder Alone And Individuals With Probable Dual Diagnosis, Elizabeth K. Cridland, Frank P. Deane, Ching-I Hsu, Peter J. Kelly
Frank Deane
The co-occurrence of substance use and mental health problems, often referred to as dual diagnosis (DD), is increasingly recognised as commonplace within substance abuse treatment programs. Two-hundred and thirty-four individuals from 9 Australian Salvation Army drug and alcohol rehabilitation programs completed a 3-month post-discharge telephone follow-up. Using a cut-off score from the Psychiatric Subscale of the Addiction Severity Index (5th ed.), 66.7% were classified as likely to have DD and 33.3% as substance use disorder only (SUD). Both groups reported comparable and decreased substance use levels at follow-up, yet DD individuals perceived less improvement in substance use problems. Comparable improvements …
Using The Theory Of Planned Behavior And Barriers To Treatment To Predict Intention To Enter Further Treatment Following Residential Drug And Alcohol Detoxification: A Pilot Study, Peter J. Kelly, Frank P. Deane, Zoe Mccarthy, Trevor P. Crowe
Using The Theory Of Planned Behavior And Barriers To Treatment To Predict Intention To Enter Further Treatment Following Residential Drug And Alcohol Detoxification: A Pilot Study, Peter J. Kelly, Frank P. Deane, Zoe Mccarthy, Trevor P. Crowe
Trevor Crowe
There has been limited research examining the impact of clients’ behavioural beliefs on whether they intend to access further treatment following residential drug and alcohol detoxification. Treatment post-detoxification is generally recommended to reduce relapse and for more sustained positive outcomes. The present pilot study examined the extent to which (1) primary components of the Theory of Planned Behaviour (TPB), (2) perceived barriers to accessing treatment and (3) the participants’ previous involvement in substance abuse treatment predicted intentions to enter further treatment following residential detoxification. One hundred and sixty eight participants accessing Salvation Army detoxification units in Australia completed a survey …
Nurse's Beliefs And Knowledge About Medications Are Associated With Their Difficulties Using Patient Treatment Adherence Strategies, Mitchell Byrne, Frank Deane, Tim Coombs
Nurse's Beliefs And Knowledge About Medications Are Associated With Their Difficulties Using Patient Treatment Adherence Strategies, Mitchell Byrne, Frank Deane, Tim Coombs
Mitchell K Byrne
Background: The attitudes and beliefs of patients toward their treatment have been found to be an important factor in treatment outcome, particularly as it relates to treatment adherence. There are also suggestions that knowledge, attitudes and beliefs held by nurses about treatments may also be important influences on treatment outcome but there has been little research relating these to specific clinical behaviour. Aims: This study explored the knowledge and beliefs of nurses toward neuroleptic medications in the treatment of severe mental ill health with the view to identifying specific nurse training needs. Method: A convenience sample of 64 nurses was …
Study Protocol: A Randomized Controlled Trial Of A Computer-Based Depression And Substance Abuse Intervention For People Attending Residential Substance Abuse Treatment, Peter J. Kelly, Frances Kay-Lambkin, Amanda Baker, Frank P. Deane, Adam C. Brooks, Alexandra Mitchell, Sarah Marshall, Meredith Whittington, Genevieve A. Dingle
Study Protocol: A Randomized Controlled Trial Of A Computer-Based Depression And Substance Abuse Intervention For People Attending Residential Substance Abuse Treatment, Peter J. Kelly, Frances Kay-Lambkin, Amanda Baker, Frank P. Deane, Adam C. Brooks, Alexandra Mitchell, Sarah Marshall, Meredith Whittington, Genevieve A. Dingle
Frank Deane
"Background: A large proportion of people attending residential alcohol and other substance abuse treatment have a co-occurring mental illness. Empirical evidence suggests that it is important to treat both the substance abuse problem and co-occurring mental illness concurrently and in an integrated fashion. However, the majority of residential alcohol and other substance abuse services do not address mental illness in a systematic way. It is likely that computer delivered interventions could improve the ability of substance abuse services to address co-occurring mental illness. This protocol describes a study in which we will assess the effectiveness of adding a computer delivered …
Short- And Long-Term Effects Of Antipsychotic Drug Treatment On Weight Gain And H1 Receptor Expression, Kelly Newell, Xu-Feng Huang, Chao Deng, Tom Burne, Mei Han
Short- And Long-Term Effects Of Antipsychotic Drug Treatment On Weight Gain And H1 Receptor Expression, Kelly Newell, Xu-Feng Huang, Chao Deng, Tom Burne, Mei Han
Xu-Feng Huang
The present study investigated body weight gain, food intake, open-field activity and brain histamine H1 receptor mRNA and protein expression in rats treated with three types of antipsychotics. Rats were divided into eight groups and treated with aripiprazole (2.25mg/kg/day), olanzapine (1.5mg/kg/day), haloperidol (0.3mg/kg/day) or vehicle (as control) for 1 or 12 weeks. Administration of olanzapine for 1 week led to a threefold increase in body weight gain and a 35% increase in fat deposits compared to controls (p<0.05). In the 12-week olanzapine treatment group, accumulative food intake was significantly higher in the first 7 weeks of treatment compared to …