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Articles 1 - 30 of 35
Full-Text Articles in Arts and Humanities
Ethics Of Euthanasia And Physician Assisted Suicide, Kathryn Halloran
Ethics Of Euthanasia And Physician Assisted Suicide, Kathryn Halloran
Honors Senior Capstone Projects
No abstract provided.
From Witch Hunts To Autoantibodies: Overcoming Psychogenic Stigma To Uncover The Molecular Cause Of Autoimmunity, Emma Hainstock
From Witch Hunts To Autoantibodies: Overcoming Psychogenic Stigma To Uncover The Molecular Cause Of Autoimmunity, Emma Hainstock
Regis University Student Publications (comprehensive collection)
Due to the frequency of misdiagnosis of autoimmune diseases and their disproportionate incidence in women, my thesis explores historical misconceptions about autoimmune conditions which could have lingered in society to impede their diagnoses today. Antiphospholipid Antibody Syndrome (APS) and Anti-NMDA Receptor Encephalitis (ANRE) are the conditions I focused on, as both diseases can cause complex neurologic symptoms such as hallucinations and memory loss, which in combination with the fact that they are disproportionately suffered by women, have caused physicians in the past to misdiagnose patients as either hysteric or demonically possessed. I explore antiphospholipid antibody syndrome and anti-NMDA receptor encephalitis’s …
Review Of "Truly Human Enhancement: A Philosophical Defense Of Limits ", James Mcbain
Review Of "Truly Human Enhancement: A Philosophical Defense Of Limits ", James Mcbain
Faculty Submissions
Review of "Truly Human Enhancement: A Philosophical Defense of Limits" by Nicholas Agar.
Ethics Of Surgical Training In Developing Countries, Kevin Ramsey, Charles Weijer
Ethics Of Surgical Training In Developing Countries, Kevin Ramsey, Charles Weijer
Charles Weijer
The practice of surgical trainees operating in developing countries is gaining interest in the medical community. Although there has been little analysis about the ethical impact of these electives, there has been some concerns raised over the possible exploitation of trainees and their patients. An ethical review of this practice shows that care needs to be taken to prevent harm. Inexperienced surgeons learning surgical skills in developing countries engender greater risk of violating basic ethical principles. Advanced surgical trainees who have already achieved surgical competence are best qualified to satisfy these ethical issues. All training programs need to develop a …
A Death In The Family: Reflections On The Terri Schiavo Case, Charles Weijer
A Death In The Family: Reflections On The Terri Schiavo Case, Charles Weijer
Charles Weijer
No abstract provided.
The Secret Kappa Lambda Society Of Hippocrates (And The Origin Of The American Medical Association's Principles Of Medical Ethics), Charles T. Ambrose
The Secret Kappa Lambda Society Of Hippocrates (And The Origin Of The American Medical Association's Principles Of Medical Ethics), Charles T. Ambrose
Microbiology, Immunology, and Molecular Genetics Faculty Publications
This paper relates the neglected history of an idealistic, secret medical fraternity which existed briefly in Lexington, Kentucky, during the first half of the 19th century. It was created for students in the Medical Department at Transylvania University, the fifth US medical school, founded in 1799. One goal of the fraternity was to counter the widespread dissension and often violent quarrels among doctors that characterized American medicine of that period. And to that end, it was among the first to promote Thomas Percival's code of medical ethics in this country. Branches of the fraternity were established in Philadelphia and New …
Moral Callings And The Duty To Have Children: A Response To Jeff Mitchell, James Mcbain
Moral Callings And The Duty To Have Children: A Response To Jeff Mitchell, James Mcbain
Faculty Submissions
Jeff Mitchell argues that the good reason for having children is that parenthood is a “moral calling” and that one should heed the call out of a sense of duty and responsibility for the good of society. I argue such a “moral calling” account is mistaken, first, in that Mitchell problematically assumes the “basic intuition” is mistaken and, second, it fails to provide the epistemic conditions for the warranted belief that one would probably make a good parent (a central consideration of Mitchell’s). Thus, such a “moral calling” rationale for the having of children is not superior to rationales that …
Will The Real Charles Fried Please Stand Up?, Paul Miller, Charles Weijer
Will The Real Charles Fried Please Stand Up?, Paul Miller, Charles Weijer
Charles Weijer
In response to the preceding commentary by Jerry Menikoff in this issue of the Journal, the authors argue that Fried's central concern is not that randomized clinical trials (RCTs) are conducted without consent, but rather that various aspects of the design and conduct of RCTs are in tension with physicians' duties of personal care to their patients. Although Fried does argue that the existence of equipoise cannot justify failure to obtain consent from research subjects, informed consent by itself does not supplant ill subjects' rights to personalized judgment and care embodied in Fried's equipoise.
The Ethics Of Placebo-Controlled Trials, Charles Weijer, Kathleen Glass
The Ethics Of Placebo-Controlled Trials, Charles Weijer, Kathleen Glass
Charles Weijer
No abstract provided.
Minimal Risk And Its Implications, Charles Weijer
Minimal Risk And Its Implications, Charles Weijer
Charles Weijer
No abstract provided.
Misrepresenting Research: Commentary, Charles Weijer
Misrepresenting Research: Commentary, Charles Weijer
Charles Weijer
No abstract provided.
Benefit-Sharing And Other Protections For Communities In Genetic Research, Charles Weijer
Benefit-Sharing And Other Protections For Communities In Genetic Research, Charles Weijer
Charles Weijer
No abstract provided.
Clinical Equipoise And Not The Uncertainty Principle Is The Moral Underpinning Of The Randomised Controlled Trial, Charles Weijer, Stanley Shapiro, Kathleen Glass
Clinical Equipoise And Not The Uncertainty Principle Is The Moral Underpinning Of The Randomised Controlled Trial, Charles Weijer, Stanley Shapiro, Kathleen Glass
Charles Weijer
No abstract provided.
Reporting The Study Populations Of Clinical Trials. Clear Transmission Or Static On The Line?, Stanley Shapiro, Charles Weijer, Benjamin Freedman
Reporting The Study Populations Of Clinical Trials. Clear Transmission Or Static On The Line?, Stanley Shapiro, Charles Weijer, Benjamin Freedman
Charles Weijer
In contrast to attempts that have been made to measure the clarity of reporting of the methods of clinical trials in journal articles, we report here an attempt to measure the accuracy of methods reporting. We focus in this article on eligibility criteria as a test case for the reporting of clinical trial methods. We examined the reporting of eligibility criteria in the protocol, methods paper (if applicable), journal article, and Clinical Alert for articles appearing in print between January 1988 and September 1994 for which a Clinical Alert had been issued. Eligibility criteria were further classified into five categories …
What's The Price Of A Research Subject?, Charles Weijer
What's The Price Of A Research Subject?, Charles Weijer
Charles Weijer
No abstract provided.
Protecting Communities In Research: Philosophical And Pragmatic Challenges, Charles Weijer
Protecting Communities In Research: Philosophical And Pragmatic Challenges, Charles Weijer
Charles Weijer
The issue of the protection of communities in clinical research first arose 10 years ago in studies conducted in technologically developing countries by scientists from technologically developed nations. The question was, which ethical standards ought to apply, those of the Western investigators or local standards?
Voting Ourselves Rights: A Critique Of The Canadian Medical Association Charter For Physicians, Nuala Kenny, Charles Weijer, Francoise Baylis
Voting Ourselves Rights: A Critique Of The Canadian Medical Association Charter For Physicians, Nuala Kenny, Charles Weijer, Francoise Baylis
Charles Weijer
No abstract provided.
Another Tuskegee?, Charles Weijer
Placebo-Controlled Studies In Schizophrenia: Ethical And Scientific Perspectives. Panel Discussion, T. Lemmens, P. Appelbaum, W. Carpenter, C. Mccarthy, C. Peterson, D. Streiner, Charles Weijer
Placebo-Controlled Studies In Schizophrenia: Ethical And Scientific Perspectives. Panel Discussion, T. Lemmens, P. Appelbaum, W. Carpenter, C. Mccarthy, C. Peterson, D. Streiner, Charles Weijer
Charles Weijer
No abstract provided.
Placebo-Controlled Trials In Schizophrenia: Are They Ethical? Are They Necessary?, Charles Weijer
Placebo-Controlled Trials In Schizophrenia: Are They Ethical? Are They Necessary?, Charles Weijer
Charles Weijer
The current controversy as to the proper role of the placebo control in the evaluation of new treatments for schizophrenia requires an analysis that is sensitive to both ethical and scientific issues. Clinical equipoise, widely regarded as the moral foundation of the randomized controlled trial (RCT), requires the use of best available treatment as the control in RCT. Scientific criticisms of the use of an active control are examined and none present an insuperable barrier to the use of an active control. Indeed, scrutiny of the most recent argument for the use of placebo controls, 'assay sensitivity', suggests that the …
Why Should We Include Women And Minorities In Randomized Controlled Trials?, Charles Weijer, R. Crouch
Why Should We Include Women And Minorities In Randomized Controlled Trials?, Charles Weijer, R. Crouch
Charles Weijer
No abstract provided.
Bioethics For Clinicians: 16. Dealing With Demands For Inappropriate Treatment, Charles Weijer, Peter Singer, Bernard Dickens, Stephen Workman
Bioethics For Clinicians: 16. Dealing With Demands For Inappropriate Treatment, Charles Weijer, Peter Singer, Bernard Dickens, Stephen Workman
Charles Weijer
Demands by Patients or their Families for treatment thought to be inappropriate by health care providers constitute an important set of moral problems in clinical practice. A variety of approaches to such cases have been described in the literature, including medical futility, standard of care and negotiation. Medical futility fails because it confounds morally distinct cases: demand for an ineffective treatment and demand for an effective treatment that supports a controversial end (e.g., permanent unconsciousness). Medical futility is not necessary in the first case and is harmful in the second. Ineffective treatment falls outside the standard of care, and thus …
Self Interest Is Not The Sole Legitimate Basis For Making Decisions, Charles Weijer
Self Interest Is Not The Sole Legitimate Basis For Making Decisions, Charles Weijer
Charles Weijer
No abstract provided.
Cardiopulmonary Resuscitation For Patients In A Persistent Vegetative State: Futile Or Acceptable?, Charles Weijer
Cardiopulmonary Resuscitation For Patients In A Persistent Vegetative State: Futile Or Acceptable?, Charles Weijer
Charles Weijer
No abstract provided.
A Study In Contrasts: Eligibility Criteria In A Twenty-Year Sample Of Nsabp And Pog Clinical Trials, Abraham Fuks, Charles Weijer, Benjamin Freedman, Stanley Shapiro, Myriam Skrutkowska, Amina Riaz
A Study In Contrasts: Eligibility Criteria In A Twenty-Year Sample Of Nsabp And Pog Clinical Trials, Abraham Fuks, Charles Weijer, Benjamin Freedman, Stanley Shapiro, Myriam Skrutkowska, Amina Riaz
Charles Weijer
We studied changes in eligibility criteria--the largest impediment to patient accrual--in two samples of clinical trials. Trials from the NSABP (National Surgical Adjuvant Breast and Bowel Program) and POG (Pediatric Oncology Group) were analyzed. After eliminating duplications, the criteria in each protocol were enumerated and classified according to a novel schema. NSABP trials contained significantly more criteria than POG trials, and added precision criteria (making study populations homogeneous) at a faster rate than POG studies. The difference between NSABP studies (explanatory trials) and POG studies (pragmatic trials) suggest that large numbers of eligibility criteria are not necessary for quality studies. …
Uwomj Volume 66, No 2, Summer 1997, Western University
Uwomj Volume 66, No 2, Summer 1997, Western University
University of Western Ontario Medical Journal
An interdisciplinary medical science publication, established in 1930.
Ccnp Position Paper On The Use Of Placebos In Psychiatry, William Friend, Charles Weijer
Ccnp Position Paper On The Use Of Placebos In Psychiatry, William Friend, Charles Weijer
Charles Weijer
No abstract provided.
Evolving Ethical Issues In Selection Of Subjects For Clinical Research, Charles Weijer
Evolving Ethical Issues In Selection Of Subjects For Clinical Research, Charles Weijer
Charles Weijer
Wittgenstein, in his famous critique of philosophy, noted that the influence of an idea can be such that it alters the way that we see the world. “It is like a pair of glasses on our nose through which we see whatever we look at,” he said. “It never occurs to us to take them off.” This view of the power of an idea suggests that the interpretation of an event, and what response this event calls for, can depend upon the view one has of the world. A person who is naive about medical facts may, for example, interpret …
Placebo Orthodoxy In Clinical Research I: Empirical And Methodological Myths, Benjamin Freedman, Charles Weijer, Kathleen Glass
Placebo Orthodoxy In Clinical Research I: Empirical And Methodological Myths, Benjamin Freedman, Charles Weijer, Kathleen Glass
Charles Weijer
No abstract provided.
Placebo Orthodoxy In Clinical Research Ii: Ethical, Legal, And Regulatory Myths, Benjamin Freedman, Kathleen Glass, Charles Weijer
Placebo Orthodoxy In Clinical Research Ii: Ethical, Legal, And Regulatory Myths, Benjamin Freedman, Kathleen Glass, Charles Weijer
Charles Weijer
No abstract provided.