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Full-Text Articles in Arts and Humanities
Alterations In Default Network Connectivity In Posttraumatic Stress Disorder Related To Early Life Trauma, Robyn L. Bluhm, Peter C. Williamson, Elizabeth A. Osuch, Paul A. Frewen, Todd K. Stevens, Kristine Boksman, Richard W.J. Neufeld, Jean Théberge, Ruth A. Lanius
Alterations In Default Network Connectivity In Posttraumatic Stress Disorder Related To Early Life Trauma, Robyn L. Bluhm, Peter C. Williamson, Elizabeth A. Osuch, Paul A. Frewen, Todd K. Stevens, Kristine Boksman, Richard W.J. Neufeld, Jean Théberge, Ruth A. Lanius
Philosophy Faculty Publications
Background: The "default network" consists of a number of brain regions that exhibit correlated low-frequency activity at rest and that have been suggested to be involved in the processing of self-relevant stimuli. Activity in many of these areas has also been shown to be altered in individuals with posttraumatic stress disorder (PTSD). We hypothesized that the posterior cingulate cortex (PCC)/precuneus, part of the default network, would exhibit altered connectivity at rest with other areas of the default network and regions associated with PTSD.
Methods: Seventeen medicated and unmedicated female patients with chronic posttraumatic stress disorder (PTSD) related to early-life trauma …