Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Arts and Humanities
Dietary (N-3) Long Chain Polyunsaturated Fatty Acids Inhibit Ischemia And Reperfusion Arrhythmias And Infarction In Rat Heart Not Enhanced By Ischemic Preconditioning, G. G. Abdukeyum, A. J. Owen, P. L. Mclennan
Dietary (N-3) Long Chain Polyunsaturated Fatty Acids Inhibit Ischemia And Reperfusion Arrhythmias And Infarction In Rat Heart Not Enhanced By Ischemic Preconditioning, G. G. Abdukeyum, A. J. Owen, P. L. Mclennan
P. L. McLennan
Ischaemic preconditioning is a powerful cardioprotective phenomenon. Cardioprotection afforded by (n-3) polyunsaturated fatty acids (PUFA) also suggests preconditioning-like effects. This study examined the effects of dietary fish oil on heart function and injury during myocardial ischemia and reperfusion and interactions between diet and ischemic preconditioning (IP). Male Wistar rats were fed diets containing 10% fat by weight including either 7% fish oil + 3% olive oil (n-3) PUFA); 5% sunflower seed oil + 5% olive oil ((n-6) PUFA); or 7% saturated fat-rich beef tallow + 3% olive oil (SF) for 6 weeks. Isolated perfused hearts subjected to 30min regional ischemia …