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A Comprehensive Genetic Linkage Map Of The Human Genome, Nih/Ceph Collaborators Mapping Group, Helen Donis-Keller
A Comprehensive Genetic Linkage Map Of The Human Genome, Nih/Ceph Collaborators Mapping Group, Helen Donis-Keller
Helen Donis-Keller
A genetic linkage map of the human genome was constructed that consists of 1416 loci, including 279 genes and expressed sequences. The loci are represented by 1676 polymorphic systems genotyped with the CEPH reference pedigree resource. A total of 339 microsatellite repeat markers assayed by PCR are contained within the map, and of the 351 markers with heterozygosities of at least 70%, 205 are microsatellites. Seven telomere loci define physical and genetic endpoints for 2q, 4p, 7q, 8p, 14q, 16p, and 16q, and in other cases distal markers on the maps have been localized to terminal cytogenetic bands. Therefore, at …