Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Arts and Humanities
Rna Sequencing Provides Evidence For Allelism Of Determinants Of The N-, B-, Or Nb- Tropism Of Murine Leukemia Viruses, Jean Rommelaere, Helen Donis-Keller, Nancy Hopkins
Rna Sequencing Provides Evidence For Allelism Of Determinants Of The N-, B-, Or Nb- Tropism Of Murine Leukemia Viruses, Jean Rommelaere, Helen Donis-Keller, Nancy Hopkins
Helen Donis-Keller
Previous genetic and biochemical studies identified three large RNAase T1-resistant oligonucleotides, each associated with either the N-, B- or NB-tropism of murine C-type viruses of BALB/c origin. These oligonucleotides were shown to lie in the 5′ third of the oligonucleotide maps of their respective viruses. We sequenced the three oligonucleotides and found that they share a 10 base sequence. Together these observations provide good evidence that the determinants of N-, B- or NB-tropism monitored by the three oligonucleotides are allelic.The oligonucleotides associated with N- and B-tropism differ in sequence at four of sixteen nucleotides, while the B- and NB-tropism-associated oligonucleotides …