Arts and Humanities Commons^™

Free Speech Vs. Freedom, C. Heike Schotten

C. Heike Schotten

A critique of the colonial, homonational, and neoliberal contours that define the "freedom" of "free speech" in reference to the Salaita affair.

Getting Your Bloke On: Gender Issues In The Reality Competition 'I Will Survive', Frank Miller

Frank M Miller III

The Australian reality competition "I Will Survive" set out to find a cast replacement for the leading role in the Broadway production of "Priscilla, Queen of the Desert." The stage version closed halfway through production the series, forcing a repositioning of the competition as the search to find "Australia's next triple threat." Even when the main prize was a role as a drag queen, however, the series presented a heterocentric approach to gender that treated drag less as a means of personal expression than as a part in a play that just happened to be about two gay men and …

Development Of Antigen-Specific Memory Cd8+ T Cells Following Live-Attenuated Chimeric West Nile Virus Vaccination, Heidi Smith, Thomas Monath, Pamela Pazoles, Alan Rothman, Diane Casey, Masanori Terajima, Francis Ennis, Farshad Guirakhoo, Sharone Green

Alan Rothman

ChimeriVax-WN02 is a novel live-attenuated West Nile virus (WNV) vaccine containing modified WNV premembrane (prM) and envelope (E) sequences inserted into the yellow fever 17D vaccine genome. We investigated the induction and evolution of CD8(+) T cell responses to a WNV envelope epitope, which is a dominant target in naturally infected HLA-A*02-positive individuals. WNV epitope-specific CD8(+) T cells were detected by HLA tetramer staining in 22 of 23 donors tested, with peak frequencies occurring between days 14 and 28. WNV epitope-specific T cells evolved from an effector phenotype to a long-lived memory phenotype. In the majority of donors, CD8(+) T …

Intracellular Cytokine Production By Dengue Virus-Specific T Cells Correlates With Subclinical Secondary Infection, Steven Hatch, Timothy Endy, Stephen Thomas, Anuja Mathew, James Potts, Pamela Pazoles, Daniel Libraty, Robert Gibbons, Alan Rothman

Alan Rothman

The pathophysiology of dengue virus infection remains poorly understood, although secondary infection is strongly associated with more severe disease. In the present study, we performed a nested, case-control study comparing the responses of pre-illness peripheral blood mononuclear cells between children who would subsequently develop either subclinical or symptomatic secondary infection 6-11 months after the baseline blood samples were obtained and frozen. We analyzed intracellular cytokine production by CD4(+) and CD8(+) cells in response to stimulation with dengue antigen. We found higher frequencies of dengue virus-specific TNFalpha, IFNgamma-, and IL-2-producing T cells among schoolchildren who subsequently developed subclinical infection, compared with …

Determinants Of Inapparent And Symptomatic Dengue Infection In A Prospective Study Of Primary School Children In Kamphaeng Phet, Thailand, Timothy Endy, Kathryn Anderson, Ananda Nisalak, In-Kyu Yoon, Sharone Green, Alan Rothman, Stephen Thomas, Richard Jarman, Daniel Libraty, Robert Gibbons

Alan Rothman

BACKGROUND: Dengue viruses are a major cause of morbidity in tropical and subtropical regions of the world. Inapparent dengue is an important component of the overall burden of dengue infection. It provides a source of infection for mosquito transmission during the course of an epidemic, yet by definition is undetected by health care providers. Previous studies of inapparent or subclinical infection have reported varying ratios of symptomatic to inapparent dengue infection.

METHODOLOGY/PRINCIPAL FINDINGS: In a prospective study of school children in Northern Thailand, we describe the spatial and temporal variation of the symptomatic to inapparent (S:I) dengue illness ratio. Our …

T-Cell Responses To Dengue Virus In Humans, Ichiro Kurane, Takaji Matsutani, Ryuji Suzuki, Tomohiko Takasaki, Siripen Kalayanarooj, Sharone Green, Alan Rothman, Francis Ennis

Alan Rothman

Dengue virus (DENV) is a leading cause of morbidity and mortality in most tropical and subtropical areas of the world. Dengue virus infection induces specific CD4+CD8- and CD8+CD4- T cells in humans. In primary infection, T-cell responses to DENV are serotype cross-reactive, but the highest response is to the serotype that caused the infection. The epitopes recognized by DENV-specific T cells are located in most of the structural and non-structural proteins, but NS3 is the protein that is most dominantly recognized. In patients with dengue hemorrhagic fever (DHF) caused by secondary DENV infection, T cells are highly activated in vivo. …

B-Cell Responses During Primary And Secondary Dengue Virus Infections In Humans, Anuja Mathew, Kim West, Siripen Kalayanarooj, Robert Gibbons, Anon Srikiatkhachorn, Sharone Green, Daniel Libraty, Smita Jaiswal, Alan Rothman

Alan Rothman

Low-avidity serotype-cross-reactive antibodies are hypothesized to play a key role in triggering severe disease in patients with secondary dengue virus (DENV) infection. However, there is little systematic information about the frequency, avidity, and cross-reactivity of DENV-specific B cells in individuals experiencing primary instead of secondary infection. We compared DENV-specific B-cell responses in a cohort of Thai children with primary or secondary DENV infection. B cells specific for DENV precursor membrane protein, envelope (E) protein, and nonstructural protein 1 were detectable in immune peripheral blood mononuclear cells with the highest frequencies of DENV E-specific B cells detected in patients experiencing primary …

Popular Depression: How Literature Is Affecting The Female Image, Samantha Bloodworth

Samantha Murillo

No abstract provided.

Women, The Novel, And Natural Philosophy, 1660-1727, Karen Gevirtz

Karen Bloom Gevirtz

Women, the Novel, and Natural Philosophy, 1660-1727 shows how early women novelists drew on debates about the self generated by the 'scientific' revolution to establish the novel as a genre and literary omniscience as a point of view. These writers such as Aphra Behn, Jane Barker, Eliza Haywood, and Mary Davys used, tested, explored, accepted, and rejected ideas about the self in their works to represent the act of knowing and what it means to be a knowing self. Karen Bloom Gevirtz agues that as they did so, they developed structures for representing authoritative knowing that contributed to the development …

Hints For Wive--And Husbands, Sherry Penney, James Livingston

Sherry Penney

This article reveals, for the first time, the "humorous article" read by Lucretia Mott at the historic 1848 Seneca Falls Women's Rights Convention. Written by Mott's sister Martha Coffin Wright, it presents a view of the gender roles in marriage very different from that expressed in most literature of its time.

Gender And Space In British Literature, 1660-1820, Karen Gevirtz

Karen Bloom Gevirtz

Black Women’S Perceptions Of The Relationship Among Nepotism, Cronyism Job Satisfaction, And Job-Focused Self-Efficacy, Johnson Chandler

Johnson LaVoria Chandler

Corporate America struggles with inclusion of certain groups such as Black women. Although Black women have met or surpassed their Caucasian, Hispanic, Asian, and Native American female counterparts and their Black male counterparts in education, and sit on boards of Fortune 500 companies, too many Black women are stymied in attempts for advancement as a result of nepotism and cronyism. Oftentimes, Black women are left with feelings of incompetence and believing they are undervalued in the workplace.

This study examined Black women's perceptions of nepotism and cronyism in the workplace. Further, the study was conducted to establish to what extent …

Development Of Antigen-Specific Memory Cd8+ T Cells Following Live-Attenuated Chimeric West Nile Virus Vaccination, Heidi Smith, Thomas Monath, Pamela Pazoles, Alan Rothman, Diane Casey, Masanori Terajima, Francis Ennis, Farshad Guirakhoo, Sharone Green

Sharone Green

ChimeriVax-WN02 is a novel live-attenuated West Nile virus (WNV) vaccine containing modified WNV premembrane (prM) and envelope (E) sequences inserted into the yellow fever 17D vaccine genome. We investigated the induction and evolution of CD8(+) T cell responses to a WNV envelope epitope, which is a dominant target in naturally infected HLA-A*02-positive individuals. WNV epitope-specific CD8(+) T cells were detected by HLA tetramer staining in 22 of 23 donors tested, with peak frequencies occurring between days 14 and 28. WNV epitope-specific T cells evolved from an effector phenotype to a long-lived memory phenotype. In the majority of donors, CD8(+) T …

B-Cell Responses During Primary And Secondary Dengue Virus Infections In Humans, Anuja Mathew, Kim West, Siripen Kalayanarooj, Robert Gibbons, Anon Srikiatkhachorn, Sharone Green, Daniel Libraty, Smita Jaiswal, Alan Rothman

Sharone Green

Low-avidity serotype-cross-reactive antibodies are hypothesized to play a key role in triggering severe disease in patients with secondary dengue virus (DENV) infection. However, there is little systematic information about the frequency, avidity, and cross-reactivity of DENV-specific B cells in individuals experiencing primary instead of secondary infection. We compared DENV-specific B-cell responses in a cohort of Thai children with primary or secondary DENV infection. B cells specific for DENV precursor membrane protein, envelope (E) protein, and nonstructural protein 1 were detectable in immune peripheral blood mononuclear cells with the highest frequencies of DENV E-specific B cells detected in patients experiencing primary …

Long Term Recall Of Memory Cd8 T Cells In Mice To First And Third Generation Smallpox Vaccines, Sharone Green, Francis Ennis, Anuja Mathew

Sharone Green

Since long-term immunity is a critical component of any effective vaccine, we compared over a 15-month period, the strength, durability and specificity of immunity of an attenuated smallpox vaccine Modified Vaccinia Ankara (MVA) to the New York City Board of Health (NYCBH) vaccine. The frequencies of CD8(+) T cells to an immunodominant CD8 T cell epitope B8R(20-27) remained remarkably stable in mice given either MVA or NYCBH. Both groups were also protected from a lethal intranasal challenge with Western Reserve strain of vaccinia virus (VACV-WR). Cytokine responses to virus-specific peptides were detectable with significant boosting upon challenge. Expression of most …

Playing The Changeling Architecturally, Kim Solga

Kim Solga

Performing Environments is an original and important collection examining site specificity in a diverse range of medieval and early modern performance cultures. The chapters take up theories of site specificity more commonly deployed in the study of contemporary work in order to raise new questions and suggest innovative approaches to the study of performance in the historical past. The book provides an introduction to site specific theories as well as a review of the recent 'geographical turn' in medieval and early modern scholarship that frames the studies for both novice and expert readers. Individual chapters explore both theatrical performances and …

Police-Building And The Responsibility To Protect: Civil Society, Gender And Human Rights Culture In Oceania, Charles Hawksley, Nichole Georgeou

Nichole Georgeou

Forthcoming: This book examines how the United Nations and states provide assistance for the police services of developing states to help them meet their human rights obligations to their citizens, under the responsibility to protect (R2P) provisions. It examines police-capacity building ("police-building") by international donors in Timor-Leste, Solomon Islands and Papua New Guinea (PNG). All three states have been described as "fragile states" and "states of concern", and all have witnessed significant social tensions and violence in the past decades. The authors argue that globally police-building forms part of an attempt to make states "safe" so that they can adhere …

Rtop's Second Pillar: The Responsibility To Assist In Theory And Practice In Solomon Islands, Charles Hawksley, Nichole Georgeou

Nichole Georgeou

This paper explores the implementation of a regional capacity-building program in Solomon Islands, a state that experienced significant violence and political tension between 1998 and 2003. The July 2003 intervention of the Regional Assistance Mission to Solomon Islands (RAMSI) is a useful and relevant case study for understanding the operationalization of Pillar II of RtoP, which the authors have termed the “Responsibility to Assist” (RtoA). While RAMSI has not consciously adopted RtoP language in its operations, the rationale for the intervention included humanitarian as well as wider regional security concerns. The mission’s emphasis on developing the state’s capacities in policing …

Marriage Rights For Transgender People In Hong Kong: Reading The W Case, John Nguyet Erni

Professor John Nguyet Erni