Arts and Humanities Commons^™

Effects Of Adoptive Transfer Of Beta-Amyloid Sensitive Immune Cells In A Mouse Model For Alzheimer’S Disease, Daniel Shippy

USF Tampa Graduate Theses and Dissertations

One major therapeutic target for preventing and treating Alzheimer's Disease (AD) is removal of excess β-amyloid (Aβ) from the brain. Both active and passive immunotherapies targeting Aβ have proven effective in reducing brain Aβ levels and improving cognitive function in mouse transgenic models of AD. However, these approaches can induce adverse neuropathologic effects and immunologic over-activation. Indeed, clinical trials of active Aβ immunotherapy in AD patients were halted due to development of meningoencephalitis, apparently resulting from wide-spread neuroinflammation. Here we show that a more restricted and specific immune re-activation through a single adoptive transfer of Aβ-specific T cells can provide …

Dissecting Out The Contribution Of Cognitive, Social, And Physical Activities To Environmental Enrichment’S Ability To Protect Alzheimer’S Mice Against Cognitive Impairment, Jennifer R. Cracchiolo

USF Tampa Graduate Theses and Dissertations

Retrospective studies suggest that lifestyle activities may provide protection against Alzheimer s Disease (AD). However, such studies can be inaccurate and prospective longitudinal studies investigating lifestyle protection against AD are both impractical and impossible to control for. Transgenic (Tg+) AD mice offer a model in a well controlled environment for testing the potential for environmental factors to impact AD development. In an initial study, Tg+ and non-transgenic (Tg-) mice were housed in either environmentally enriched (EE) or standard housing (SH) from 2-6 months of age, with a behavioral battery given during the last 5 weeks of housing. In the Morris …

A Comparison Of Two Prompting Procedures On Tacting Behavior, Kelley N. Gardner

USF Tampa Graduate Theses and Dissertations

The focus of the current study was to determine the most effective way to teach tacts, or labels, to children with autism who have a language deficit. Two participants were included in the study, which compared two prompting procedures, the verbal prompting condition and the gestural prompting condition.

The verbal prompting condition included presenting a target picture and the verbal prompt, “What is it?” In the gestural prompting condition, a picture was presented, but rather than the verbal prompt, a pointing prompt was offered. Approximately 32 sessions were conducted 2-3 times per week. The effects of the two interventions were …

The Effects Of Response Cards On The Performance And Generalization Of Parenting Skills, Bennie L. Colbert

USF Tampa Graduate Theses and Dissertations

Previous research has provided convincing evidence of the efficacy of behavior analytic interventions to improve parenting skills with biological parents, however many studies lament generalization failure from training to home settings. Previous research has also examined the effects of response card use with children at various grade levels and with post-secondary students with a sole focus on academic outcomes. This study examined the effects of color coded response cards on active student responding and parenting skills proficiency of three foster parents in a parent training program and generalization of these skills to their homes. During baseline, participants role-played their responses …