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Full-Text Articles in Arts and Humanities
Mode Of Action And Structure-Activity Studies Of N-Alkylthio Beta-Lactams And N-Alkylthio-2-Oxazolidinones, And Synthesis Of Second-Generation Disulfide Inhibitors Of Beta-Ketoacyl-Acyl Carrer Protein Synthase Iii (Fabh) As Potent Antibacterial Agents, Kevin David Revell
USF Tampa Graduate Theses and Dissertations
Work in the Turos group over the past five years has focused on the development of N-alkylthio beta-lactams, which show antibacterial activity against Staphylococcus (including MRSA), Bacillus, and others. These compounds do not function in the manner of the traditional beta-lactam antibiotics, but were thought to undergo an intracellular thiol-transfer to coenzyme A. In expanding the SAR of these novel compounds, it was found that N-alkylthio-2-oxazolidinones also exhibit antibacterial activity. Although CoA acts as the thiol-redox buffer in the genera most susceptible to the N-alkylthio beta-lactams, studies on Coenzyme A disulfide reductase (CoADR) show that the redox buffer is not …
Laboratory Analysis Of Staphylococcus Aureus In Florida From January 1, 2003 To December 31, 2005 With An Emphasis On Methicillin Resistance, Stephanie Kolar
Laboratory Analysis Of Staphylococcus Aureus In Florida From January 1, 2003 To December 31, 2005 With An Emphasis On Methicillin Resistance, Stephanie Kolar
USF Tampa Graduate Theses and Dissertations
The Staphylococci are gram-positive bacteria that cause infections in humans and can produce severe morbidity and mortality. Methicillin resistant S. aureus (MRSA) isolates are resistant to all beta-lactam antibiotics, such as methicillin, and cephalosporins making treatment of these infections more difficult. MRSA has become prevalent throughout the United States, spreading in the health care setting and the community.The purpose of this study is to examine methicillin resistance among S. aureus isolates in an outpatient population in the state of Florida and asses possible associations between methicillin resistance and age group, gender, and geographic area. It is important to define methicillin …
N-Thiolated B-Lactam Antibiotics: Synthesis And Structure-Activity Studies Of C3 Oxygenated Derivatives And Attachement To New, Functionalized Caprolactone Monomers And Polymers, J Michelle Leslie
USF Tampa Graduate Theses and Dissertations
N-Thiolated beta-lactams are a new class of anti-MRSA and anti-Bacillus agents that have recently been reported by our laboratories. From previous studies performed in our laboratories, it is believed that the N-thiolated beta-lactams exert their antimicrobial activity through a unique mode of action that is completely unlike that of classical beta-lactam antibiotics. In the first chapter of this dissertation, a review of previously prepared N-thiolated beta-lactam analogues and their mode of action is presented. In the second chapter, the synthesis of seven different C3-oxygenated derivatives is described. These analogues were tested for antibacterial activity against Staphylococcus aureus, nine different strains …