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Pilot Gwas Of Caries In African-Americans Shows Genetic Heterogeneity, E. Orlova, J. C. Carlson, M. K. Lee, E. Feingold, D. W. Mcneil, R. J. Crout, R. J. Weyant, M. L. Marazita, J. R. Shaffer
Pilot Gwas Of Caries In African-Americans Shows Genetic Heterogeneity, E. Orlova, J. C. Carlson, M. K. Lee, E. Feingold, D. W. Mcneil, R. J. Crout, R. J. Weyant, M. L. Marazita, J. R. Shaffer
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Background
Dental caries is the most common chronic disease in the US and disproportionately affects racial/ethnic minorities. Caries is heritable, and though genetic heterogeneity exists between ancestries for a substantial portion of loci associated with complex disease, a genome-wide association study (GWAS) of caries specifically in African Americans has not been performed previously.
Methods
We performed exploratory GWAS of dental caries in 109 African American adults (age > 18) and 96 children (age 3–12) from the Center for Oral Health Research in Appalachia (COHRA1 cohort). Caries phenotypes (DMFS, DMFT, dft, and dfs indices) assessed by dental exams were tested for association …