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Clinical And Microbiologic Investigation Of An Expedited Peri-Implantitis Dog Model: An Animal Study, Wook Jin Seong, Georgios Kotsakis, Jong-Ki Huh, Soo Cheol Jeong, Ki Young Nam, Jong Ryul Kim, Young Cheul Heo, Hyeon-Cheol Kim, Lei Zhang, Michael D. Evans, Heather Conrad, Robert J. Schumacher
Clinical And Microbiologic Investigation Of An Expedited Peri-Implantitis Dog Model: An Animal Study, Wook Jin Seong, Georgios Kotsakis, Jong-Ki Huh, Soo Cheol Jeong, Ki Young Nam, Jong Ryul Kim, Young Cheul Heo, Hyeon-Cheol Kim, Lei Zhang, Michael D. Evans, Heather Conrad, Robert J. Schumacher
Faculty & Staff Scholarship
Background: Animal studies are pivotal in allowing experimentation to identify efficacious treatment protocols for resolution of peri-implantitis. The purpose of this investigation was to characterize an expedited dog peri-implantitis model clinically, radiographically, and microbiologically. Methods: Eight hound dogs underwent extractions (week 0) and implant (3.3 × 8.5 mm) placement with simultaneous surgical defect creation and ligature placement for induction of peri-implantitis (week 10). Ligatures were replaced at 6 weeks (week 16) and removed after 9 weeks (week 19) when supporting bone loss involved approximately 50% of the peri-implant bone. Microbial samples from the defects and healthy control implant sites collected …